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- W2797517655 endingPage "67" @default.
- W2797517655 startingPage "61" @default.
- W2797517655 abstract "Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons' activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils' effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma." @default.
- W2797517655 created "2018-04-24" @default.
- W2797517655 creator A5012593977 @default.
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- W2797517655 date "2018-04-06" @default.
- W2797517655 modified "2023-10-17" @default.
- W2797517655 title "Eosinophil and airway nerve interactions in asthma" @default.
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