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• W2797717070 abstract "Mechanical stresses elicit cellular reactions mediated by chemical signals. Defective responses to forces underlie human medical disorders, such as cardiac failure and pulmonary injury. Despite detailed knowledge of the cytoskeleton's structure, the specific molecular switches that convert mechanical stimuli into chemical signals have remained elusive. Here we identify the actin-binding protein, filamin A (FLNa) as a central mechanotransduction element of the cytoskeleton by using Fluorescence Loss After photo Conversion (FLAC), a novel high-speed alternative to FRAP." @default.
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• W2797717070 date "2012-01-01" @default.
• W2797717070 modified "2023-09-26" @default.
• W2797717070 title "Mechanical Strain in Actin Networks Regulates FilGAP and Integrin Binding to Filamin A" @default.
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• W2797717070 doi "https://doi.org/10.1016/j.bpj.2011.11.1905" @default.
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