FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797777892> ?p ?o ?g. }

• W2797777892 endingPage "1879" @default.
• W2797777892 startingPage "1872" @default.
• W2797777892 abstract "Relebactam is an inhibitor of class A β-lactamases, including KPC β-lactamases, and class C β-lactamases, and is currently under clinical development in combination with imipenem. The objective of the current study was to evaluate the in vitro activity of imipenem/relebactam against Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) submitted by clinical laboratories in 17 European countries to the Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance programme in 2015. MICs were determined using the CLSI standard broth microdilution method and interpreted using EUCAST clinical breakpoints. Relebactam was tested at a fixed concentration of 4 mg/L in combination with doubling dilutions of imipenem. Imipenem/relebactam MICs were interpreted using breakpoints for imipenem. Rates of susceptibility to imipenem and imipenem/relebactam for isolates of P. aeruginosa (n = 1705), K. pneumoniae (n = 1591) and Enterobacter spp. (n = 772) were 72.0/94.7%, 88.7/94.8% and 95.6/96.8%, respectively. Relebactam restored imipenem susceptibility to 81.1%, 54.2% and 26.5% of imipenem-non-susceptible isolates of P. aeruginosa (n = 477), K. pneumoniae (n = 179) and Enterobacter spp. (n = 34). Most imipenem/relebactam-non-susceptible isolates carried MBLs, OXA-48 or GES carbapenemases. Relebactam did not increase the number of isolates of A. baumannii (n = 486) susceptible to imipenem. Relebactam restored susceptibility to imipenem for the majority of imipenem-non-susceptible isolates of P. aeruginosa and K. pneumoniae tested as well as some isolates of imipenem-non-susceptible Enterobacter spp. Based on our results, imipenem/relebactam appears to be a promising therapeutic option for treating patients with infections caused by antimicrobial-resistant Gram-negative bacilli." @default.
• W2797777892 created "2018-04-24" @default.
• W2797777892 creator A5017159626 @default.
• W2797777892 creator A5038009031 @default.
• W2797777892 creator A5042149117 @default.
• W2797777892 creator A5061522332 @default.
• W2797777892 creator A5063899317 @default.
• W2797777892 creator A5066677972 @default.
• W2797777892 creator A5076320612 @default.
• W2797777892 creator A5089366807 @default.
• W2797777892 date "2018-04-11" @default.
• W2797777892 modified "2023-10-17" @default.
• W2797777892 title "In vitro activity of imipenem/relebactam against Gram-negative ESKAPE pathogens isolated in 17 European countries: 2015 SMART surveillance programme" @default.
• W2797777892 cites W1902535075 @default.
• W2797777892 cites W1983774126 @default.
• W2797777892 cites W2043982549 @default.
• W2797777892 cites W2059728033 @default.
• W2797777892 cites W2092279762 @default.
• W2797777892 cites W2099303284 @default.
• W2797777892 cites W2102821548 @default.
• W2797777892 cites W2103121782 @default.
• W2797777892 cites W2104843155 @default.
• W2797777892 cites W2106204528 @default.
• W2797777892 cites W2115486016 @default.
• W2797777892 cites W2116644484 @default.
• W2797777892 cites W2129772896 @default.
• W2797777892 cites W2134789996 @default.
• W2797777892 cites W2139911027 @default.
• W2797777892 cites W2168519960 @default.
• W2797777892 cites W2201379139 @default.
• W2797777892 cites W2288514582 @default.
• W2797777892 cites W2408072278 @default.
• W2797777892 cites W2587010349 @default.
• W2797777892 doi "https://doi.org/10.1093/jac/dky107" @default.
• W2797777892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29659861" @default.
• W2797777892 hasPublicationYear "2018" @default.
• W2797777892 type Work @default.
• W2797777892 sameAs 2797777892 @default.
• W2797777892 citedByCount "65" @default.
• W2797777892 countsByYear W27977778922018 @default.
• W2797777892 countsByYear W27977778922019 @default.
• W2797777892 countsByYear W27977778922020 @default.
• W2797777892 countsByYear W27977778922021 @default.
• W2797777892 countsByYear W27977778922022 @default.
• W2797777892 countsByYear W27977778922023 @default.
• W2797777892 crossrefType "journal-article" @default.
• W2797777892 hasAuthorship W2797777892A5017159626 @default.
• W2797777892 hasAuthorship W2797777892A5038009031 @default.
• W2797777892 hasAuthorship W2797777892A5042149117 @default.
• W2797777892 hasAuthorship W2797777892A5061522332 @default.
• W2797777892 hasAuthorship W2797777892A5063899317 @default.
• W2797777892 hasAuthorship W2797777892A5066677972 @default.
• W2797777892 hasAuthorship W2797777892A5076320612 @default.
• W2797777892 hasAuthorship W2797777892A5089366807 @default.
• W2797777892 hasBestOaLocation W27977778921 @default.
• W2797777892 hasConcept C104317684 @default.
• W2797777892 hasConcept C176947019 @default.
• W2797777892 hasConcept C2776315533 @default.
• W2797777892 hasConcept C2776685102 @default.
• W2797777892 hasConcept C2777058267 @default.
• W2797777892 hasConcept C2777637488 @default.
• W2797777892 hasConcept C2778523567 @default.
• W2797777892 hasConcept C2778910516 @default.
• W2797777892 hasConcept C2778983983 @default.
• W2797777892 hasConcept C2779631663 @default.
• W2797777892 hasConcept C2780950330 @default.
• W2797777892 hasConcept C4937899 @default.
• W2797777892 hasConcept C501593827 @default.
• W2797777892 hasConcept C523546767 @default.
• W2797777892 hasConcept C54355233 @default.
• W2797777892 hasConcept C547475151 @default.
• W2797777892 hasConcept C55493867 @default.
• W2797777892 hasConcept C71924100 @default.
• W2797777892 hasConcept C86803240 @default.
• W2797777892 hasConcept C89423630 @default.
• W2797777892 hasConcept C94665300 @default.
• W2797777892 hasConceptScore W2797777892C104317684 @default.
• W2797777892 hasConceptScore W2797777892C176947019 @default.
• W2797777892 hasConceptScore W2797777892C2776315533 @default.
• W2797777892 hasConceptScore W2797777892C2776685102 @default.
• W2797777892 hasConceptScore W2797777892C2777058267 @default.
• W2797777892 hasConceptScore W2797777892C2777637488 @default.
• W2797777892 hasConceptScore W2797777892C2778523567 @default.
• W2797777892 hasConceptScore W2797777892C2778910516 @default.
• W2797777892 hasConceptScore W2797777892C2778983983 @default.
• W2797777892 hasConceptScore W2797777892C2779631663 @default.
• W2797777892 hasConceptScore W2797777892C2780950330 @default.
• W2797777892 hasConceptScore W2797777892C4937899 @default.
• W2797777892 hasConceptScore W2797777892C501593827 @default.
• W2797777892 hasConceptScore W2797777892C523546767 @default.
• W2797777892 hasConceptScore W2797777892C54355233 @default.
• W2797777892 hasConceptScore W2797777892C547475151 @default.
• W2797777892 hasConceptScore W2797777892C55493867 @default.
• W2797777892 hasConceptScore W2797777892C71924100 @default.
• W2797777892 hasConceptScore W2797777892C86803240 @default.
• W2797777892 hasConceptScore W2797777892C89423630 @default.
• W2797777892 hasConceptScore W2797777892C94665300 @default.
• W2797777892 hasFunder F4320307776 @default.

• next