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- W2797788008 abstract "Abstract Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia. While the structure of the cilium is being defined at increasing resolution, centriolar structure remains poorly understood. Here, we used electron cryo-tomography to determine the structure of mammalian (triplet) and Drosophila (doublet) centrioles at 25 Å resolution. Mammalian centrioles have two distinct domains: a 200 nm proximal core region connected by A-C linkers, and a distal domain where the C-tubule is incomplete and a pair of novel linkages stabilize the assembly producing a geometry more closely resembling the ciliary axoneme. Drosophila centrioles more closely resemble the mammalian core, but with their doublets linked through A tubules. The commonality of core region length, and the abrupt transition in mammalian centrioles, suggests a conserved length-setting mechanism. The unexpected linker diversity suggests how unique centriolar architectures arise in different tissues and organisms." @default.
- W2797788008 created "2018-04-24" @default.
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- W2797788008 date "2018-04-12" @default.
- W2797788008 modified "2023-10-14" @default.
- W2797788008 title "Insights into centriole biogenesis and evolution revealed by cryoTomography of doublet and triplet centrioles" @default.
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- W2797788008 doi "https://doi.org/10.1101/300525" @default.
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