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- W2797796352 endingPage "146" @default.
- W2797796352 startingPage "135" @default.
- W2797796352 abstract "B-cell non-Hodgkin's lymphoma (NHLs)is a very heterogonous malignancy with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) as the most common subtypes. Standard treatment with anti-CD20 based chemoimmunotherapy is usually very effective for disease control. However a significant proportion of patients with high-risk features (double hit lymphoma, transformed lymphomas or early relapses) will become refractory to standard therapies and will have limited alternatives for cure. Adoptive therapy with chimeric antigen receptor (CAR) T-cells is a new paradigm for effective treatment of poor prognosis lymphomas. Here we review the biology of poor risk DLBCL and FL, the rationale for CAR T-cell therapy in malignant lymphoma and the efficacy/toxicity profile of CD19 directed CAR T cell therapy for DLBCL and FL from early single center studies to multicenter/global clinical trial with different CAR T cell constructs." @default.
- W2797796352 created "2018-04-24" @default.
- W2797796352 creator A5021394406 @default.
- W2797796352 creator A5084789778 @default.
- W2797796352 date "2018-06-01" @default.
- W2797796352 modified "2023-10-11" @default.
- W2797796352 title "CAR T cell therapy for B-cell lymphomas" @default.
- W2797796352 cites W1505869554 @default.
- W2797796352 cites W1532323392 @default.
- W2797796352 cites W1799746163 @default.
- W2797796352 cites W1801682147 @default.
- W2797796352 cites W1956825767 @default.
- W2797796352 cites W1963522404 @default.
- W2797796352 cites W1965498936 @default.
- W2797796352 cites W1966542058 @default.
- W2797796352 cites W1970648523 @default.
- W2797796352 cites W1971659434 @default.
- W2797796352 cites W1974431455 @default.
- W2797796352 cites W1983056774 @default.
- W2797796352 cites W1986579589 @default.
- W2797796352 cites W1988817337 @default.
- W2797796352 cites W1991890073 @default.
- W2797796352 cites W1993577803 @default.
- W2797796352 cites W2000297273 @default.
- W2797796352 cites W2003262666 @default.
- W2797796352 cites W2006070956 @default.
- W2797796352 cites W2009002059 @default.
- W2797796352 cites W2018071905 @default.
- W2797796352 cites W2024373518 @default.
- W2797796352 cites W2024972915 @default.
- W2797796352 cites W2028850684 @default.
- W2797796352 cites W2029192827 @default.
- W2797796352 cites W2030259772 @default.
- W2797796352 cites W2037796411 @default.
- W2797796352 cites W2037904581 @default.
- W2797796352 cites W2043622833 @default.
- W2797796352 cites W2044352858 @default.
- W2797796352 cites W2045330558 @default.
- W2797796352 cites W2049910239 @default.
- W2797796352 cites W2056662191 @default.
- W2797796352 cites W2057239580 @default.
- W2797796352 cites W2057389857 @default.
- W2797796352 cites W2063691874 @default.
- W2797796352 cites W2064223130 @default.
- W2797796352 cites W2068343048 @default.
- W2797796352 cites W2072351874 @default.
- W2797796352 cites W2076991609 @default.
- W2797796352 cites W2079925501 @default.
- W2797796352 cites W2082708772 @default.
- W2797796352 cites W2084647551 @default.
- W2797796352 cites W2085346499 @default.
- W2797796352 cites W2087857484 @default.
- W2797796352 cites W2099570622 @default.
- W2797796352 cites W2104187048 @default.
- W2797796352 cites W2108131857 @default.
- W2797796352 cites W2118796952 @default.
- W2797796352 cites W2120415962 @default.
- W2797796352 cites W2123129311 @default.
- W2797796352 cites W2132598458 @default.
- W2797796352 cites W2133345449 @default.
- W2797796352 cites W2136268782 @default.
- W2797796352 cites W2137216850 @default.
- W2797796352 cites W2138366746 @default.
- W2797796352 cites W2140867490 @default.
- W2797796352 cites W2141681661 @default.
- W2797796352 cites W2147246240 @default.
- W2797796352 cites W2147475628 @default.
- W2797796352 cites W2150587745 @default.
- W2797796352 cites W2152162065 @default.
- W2797796352 cites W2158267770 @default.
- W2797796352 cites W2159862107 @default.
- W2797796352 cites W2160093471 @default.
- W2797796352 cites W2167556523 @default.
- W2797796352 cites W2169209759 @default.
- W2797796352 cites W2170513194 @default.
- W2797796352 cites W2170552969 @default.
- W2797796352 cites W2170716753 @default.
- W2797796352 cites W2175416579 @default.
- W2797796352 cites W2179454156 @default.
- W2797796352 cites W2219506342 @default.
- W2797796352 cites W2238242969 @default.
- W2797796352 cites W2296829012 @default.
- W2797796352 cites W2305142474 @default.
- W2797796352 cites W2310716991 @default.
- W2797796352 cites W2322790172 @default.
- W2797796352 cites W2339180098 @default.
- W2797796352 cites W2342423058 @default.
- W2797796352 cites W2343067948 @default.
- W2797796352 cites W2408097265 @default.
- W2797796352 cites W2413807845 @default.
- W2797796352 cites W2464635942 @default.
- W2797796352 cites W2504729294 @default.
- W2797796352 cites W2505010070 @default.
- W2797796352 cites W2509364267 @default.
- W2797796352 cites W2523343293 @default.
- W2797796352 cites W2532606512 @default.
- W2797796352 cites W2551251192 @default.
- W2797796352 cites W2551314481 @default.