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• W2797804714 abstract "Abstract Cisplatin is one of the most successful antitumor agents, yet also restricted by its poor cellular uptake and low selectivity. Since 3-(2-nitrophenyl) propionic acid (NPPA) has been reported as a bioreductive prodrug moiety, herein we combined NPPA with cisplatin (compound 1) to improve its lipophilicity and targetability and then to improve the antitumor outcomes. In addition, compound 2 possessing 3-phenyl propionic acid (PPA) was also synthesized as a comparison to test the influence of the NPPA to the cytotoxicity, since PPA was not a bioreductive moiety. Bioevaluations showed that 1 displayed more potent antitumor potency than cisplatin and 2, suggesting Pt(II) complexes possessing NPPA groups may be a good strategy for future platinum drug discovery." @default.
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• W2797804714 date "2019-01-01" @default.
• W2797804714 modified "2023-09-23" @default.
• W2797804714 title "Design, synthesis and biological evaluation of a novel platinum(II) complex possessing bioreductive groups for cancer therapy" @default.
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• W2797804714 doi "https://doi.org/10.1016/j.cclet.2018.04.010" @default.
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