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- W2797866384 abstract "Significance Cancer immunotherapy is a promising therapeutic intervention. However, complete and durable responses are seen in only a fraction of cancer patients. A key factor that limits therapeutic success is the lack of T cells in tumor cell regions, a profile termed “immune-excluded.” Here, we provide evidence that tumor-associated macrophages (TAMs) are an important determinant of the establishment of a T cell-excluded tumor phenotype. In human and murine tumors, we found that CD8 T cells poorly migrate and invade tumor nests due to long-lasting interactions with TAMs. The depletion of TAMs restores T cell migration and infiltration into tumor islets and improves the efficacy of anti–PD-1 immunotherapy. This study highlights the rationale of combining approaches targeting TAM and immune checkpoint proteins." @default.
- W2797866384 created "2018-04-24" @default.
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- W2797866384 date "2018-04-09" @default.
- W2797866384 modified "2023-10-14" @default.
- W2797866384 title "Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment" @default.
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- W2797866384 doi "https://doi.org/10.1073/pnas.1720948115" @default.
- W2797866384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5924916" @default.
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