FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797922659> ?p ?o ?g. }

• W2797922659 abstract "Abstract In metazoans, apoptotic cells are swiftly engulfed by phagocytes and degraded inside phagosomes. Multiple small GTPases in the Rab family are known to function in phagosome maturation by regulating vesicle trafficking. We discovered rab-35 as a new gene important for apoptotic cell clearance using an RNAi screen targeting putative Rab GTPases in Caenorhabditis elegans . We further identified TBC-10 as a putative GTPase-activating protein (GAP), and FLCN-1 and RME-4 as two putative Guanine Nucleotide Exchange Factors (GEFs), for RAB-35. RAB-35 function was found to be required for the incorporation of early endosomes to phagosomes and for the timely degradation of apoptotic cell corpses. More specifically, RAB-35 facilitates the switch of phagosomal membrane phosphatidylinositol species from PtdIns(4,5)P 2 to PtdIns(3)P and promotes the recruitment of the small GTPase RAB-5 to phagosomal surfaces, processes that are essential for phagosome maturation. Interestingly, we observed that CED-1 performs these same functions, and to a much larger extent than RAB-35. Remarkably, in addition to cell corpse degradation, RAB-35 also facilitates the recognition of cell corpses independently of the CED-1 and CED-5 pathways. RAB-35 localizes to extending pseudopods and is further enriched on nascent phagosomes, consistent with its dual roles in regulating cell corpse-recognition and phagosome maturation. Epistasis analyses indicate that rab-35 represents a novel third genetic pathway that acts in parallel to both of the canonical ced-1/6/7 and ced-2/5/10/12 engulfment pathways. We propose that RAB-35 acts as a robustness factor, leading a pathway that aids the canonical pathways for the engulfment and degradation of apoptotic cells." @default.
• W2797922659 created "2018-04-24" @default.
• W2797922659 creator A5017803794 @default.
• W2797922659 creator A5035447530 @default.
• W2797922659 creator A5073339935 @default.
• W2797922659 date "2018-04-13" @default.
• W2797922659 modified "2023-09-23" @default.
• W2797922659 title "RAB-35 aids apoptotic cell clearance by regulating cell corpse recognition and phagosome maturation" @default.
• W2797922659 cites W1485884246 @default.
• W2797922659 cites W1533988685 @default.
• W2797922659 cites W1557404455 @default.
• W2797922659 cites W1596487292 @default.
• W2797922659 cites W1867861530 @default.
• W2797922659 cites W1880487999 @default.
• W2797922659 cites W1921244251 @default.
• W2797922659 cites W1924646174 @default.
• W2797922659 cites W1967585280 @default.
• W2797922659 cites W1968020758 @default.
• W2797922659 cites W1968444356 @default.
• W2797922659 cites W1969331809 @default.
• W2797922659 cites W1977811233 @default.
• W2797922659 cites W1980283269 @default.
• W2797922659 cites W1986006829 @default.
• W2797922659 cites W1987875240 @default.
• W2797922659 cites W1989442441 @default.
• W2797922659 cites W1989952069 @default.
• W2797922659 cites W1990451002 @default.
• W2797922659 cites W1991880183 @default.
• W2797922659 cites W1991907927 @default.
• W2797922659 cites W1994971175 @default.
• W2797922659 cites W1997603072 @default.
• W2797922659 cites W1998975377 @default.
• W2797922659 cites W1999503885 @default.
• W2797922659 cites W2000388632 @default.
• W2797922659 cites W2004166535 @default.
• W2797922659 cites W2007513923 @default.
• W2797922659 cites W2008370397 @default.
• W2797922659 cites W2010688658 @default.
• W2797922659 cites W2013016555 @default.
• W2797922659 cites W2015256188 @default.
• W2797922659 cites W2016852261 @default.
• W2797922659 cites W2017398853 @default.
• W2797922659 cites W2028761302 @default.
• W2797922659 cites W2029716305 @default.
• W2797922659 cites W2032372404 @default.
• W2797922659 cites W2038492783 @default.
• W2797922659 cites W2052853635 @default.
• W2797922659 cites W2053976302 @default.
• W2797922659 cites W2057064377 @default.
• W2797922659 cites W2059346525 @default.
• W2797922659 cites W2060814715 @default.
• W2797922659 cites W2060926835 @default.
• W2797922659 cites W2061978907 @default.
• W2797922659 cites W2064197470 @default.
• W2797922659 cites W2068602646 @default.
• W2797922659 cites W2069957357 @default.
• W2797922659 cites W2070461863 @default.
• W2797922659 cites W2071481601 @default.
• W2797922659 cites W2071651950 @default.
• W2797922659 cites W2072273093 @default.
• W2797922659 cites W2074502503 @default.
• W2797922659 cites W2074602702 @default.
• W2797922659 cites W2078313196 @default.
• W2797922659 cites W2081258463 @default.
• W2797922659 cites W2082387821 @default.
• W2797922659 cites W2086104993 @default.
• W2797922659 cites W2086327073 @default.
• W2797922659 cites W2093845961 @default.
• W2797922659 cites W2094028293 @default.
• W2797922659 cites W2095785516 @default.
• W2797922659 cites W2099564767 @default.
• W2797922659 cites W2102481731 @default.
• W2797922659 cites W2113025782 @default.
• W2797922659 cites W2117521691 @default.
• W2797922659 cites W2118521701 @default.
• W2797922659 cites W2119758846 @default.
• W2797922659 cites W2120920292 @default.
• W2797922659 cites W2136243038 @default.
• W2797922659 cites W2143062219 @default.
• W2797922659 cites W2143111492 @default.
• W2797922659 cites W2144354735 @default.
• W2797922659 cites W2148745491 @default.
• W2797922659 cites W2156038276 @default.
• W2797922659 cites W2156421803 @default.
• W2797922659 cites W2159565935 @default.
• W2797922659 cites W2166595775 @default.
• W2797922659 cites W2173026122 @default.
• W2797922659 cites W2321937006 @default.
• W2797922659 cites W2471524233 @default.
• W2797922659 cites W2508382751 @default.
• W2797922659 cites W2509350040 @default.
• W2797922659 cites W2515945657 @default.
• W2797922659 cites W2617719310 @default.
• W2797922659 cites W2748345541 @default.
• W2797922659 cites W2760258166 @default.
• W2797922659 cites W2785390423 @default.
• W2797922659 cites W4211017114 @default.
• W2797922659 cites W4241031272 @default.
• W2797922659 doi "https://doi.org/10.1101/298380" @default.
• W2797922659 hasPublicationYear "2018" @default.

• next