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- W2798037197 abstract "Epicardium-derived cells (EPDCs) are an important pool of multipotent cardiovascular progenitor cells. Through epithelial-to-mesenchymal-transition (EMT), EPDCs invade the subepicardium and myocardium and further differentiate into several cell types required for coronary vessel formation. We previously showed that epicardial hypoxia inducible factor (HIF) signaling mediates the invasion of vascular precursor cells critical for patterning the coronary vasculature. Here, we examine the regulatory role of hypoxia (1% oxygen) on EPDC differentiation into vascular smooth muscle cells (VSMCs).Hypoxia stimulates EMT and enhances expression of several VSMC markers in mouse epicardial cell cultures. This stimulation is specifically blocked by inhibiting transforming growth factor-beta (TGFβ) receptor I. Further analyses indicated that hypoxia increases the expression level of TGFβ-1 ligand and phosphorylation of TGFβ receptor II, suggesting an indispensable role of the TGFβ pathway in hypoxia-stimulated VSMC differentiation. We further demonstrate that the non-canonical RhoA/Rho kinase (ROCK) pathway acts as the main downstream effector of TGFβ to modulate hypoxia’s effect on VSMC differentiation.Our results reveal a novel role of epicardial HIF in mediating coronary vasculogenesis by promoting their differentiation into VSMCs through noncanonical TGFβ signaling. These data elucidate that patterning of the coronary vasculature is influenced by epicardial hypoxic signals." @default.
- W2798037197 created "2018-04-24" @default.
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- W2798037197 creator A5055034090 @default.
- W2798037197 creator A5055749145 @default.
- W2798037197 creator A5086302566 @default.
- W2798037197 date "2018-04-13" @default.
- W2798037197 modified "2023-10-10" @default.
- W2798037197 title "Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway" @default.
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- W2798037197 doi "https://doi.org/10.3390/jcdd5020019" @default.
- W2798037197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6023394" @default.
- W2798037197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29652803" @default.
- W2798037197 hasPublicationYear "2018" @default.
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