FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2798072540> ?p ?o ?g. }

• W2798072540 endingPage "942" @default.
• W2798072540 startingPage "930" @default.
• W2798072540 abstract "Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used for the treatment of multidrug resistant infections, very few A. baumannii clinical isolates develop colistin resistance through loss of LPS biosynthesis. This may suggest that LPS loss affects virulence traits that play a role in the transmission and pathogenesis of A. baumannii. In this study we characterize multiple virulence phenotypes of colistin resistant, LPS-deficient derivatives of the ATCC 19606 strain and five multidrug resistant clinical isolates and their colistin resistant, LPS-deficient derivatives. Our results indicate that LPS loss results in growth defects compared to the parental strain in vitro both in laboratory media and human serum (competition indices of 0.58 and 7.0 × 10-7, respectively) and reduced ability to grow and disseminate in vivo (competition index 6.7 × 10-8). Infection with the LPS-deficient strain resulted in lower serum levels of pro-inflammatory cytokines TNF-α and IL-6 compared to the parent strain, and was less virulent in a mouse model of disseminated sepsis. LPS loss also significantly affected biofilm production, surface motility, growth under iron limitation and susceptibility to multiple disinfectants used in the clinical setting. These results demonstrate that LPS loss has a significant effect on multiple virulence traits, and may provide insight into the low incidence of colistin resistant strains lacking LPS that have been reported in the clinical setting." @default.
• W2798072540 created "2018-04-24" @default.
• W2798072540 creator A5035389792 @default.
• W2798072540 creator A5055214609 @default.
• W2798072540 creator A5058862777 @default.
• W2798072540 creator A5076347067 @default.
• W2798072540 creator A5078163920 @default.
• W2798072540 creator A5087945181 @default.
• W2798072540 date "2018-05-15" @default.
• W2798072540 modified "2023-10-17" @default.
• W2798072540 title "Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in <i>Acinetobacter baumannii</i>" @default.
• W2798072540 cites W1564219524 @default.
• W2798072540 cites W1593953965 @default.
• W2798072540 cites W1656495682 @default.
• W2798072540 cites W1967346383 @default.
• W2798072540 cites W1979184180 @default.
• W2798072540 cites W1981565772 @default.
• W2798072540 cites W1992995635 @default.
• W2798072540 cites W2005271347 @default.
• W2798072540 cites W2016624659 @default.
• W2798072540 cites W2025413826 @default.
• W2798072540 cites W2028439279 @default.
• W2798072540 cites W2034012142 @default.
• W2798072540 cites W2036456340 @default.
• W2798072540 cites W2041752174 @default.
• W2798072540 cites W2051577725 @default.
• W2798072540 cites W2063730198 @default.
• W2798072540 cites W2073960785 @default.
• W2798072540 cites W2096250787 @default.
• W2798072540 cites W2096425895 @default.
• W2798072540 cites W2105838577 @default.
• W2798072540 cites W2119683190 @default.
• W2798072540 cites W2119858925 @default.
• W2798072540 cites W2120061656 @default.
• W2798072540 cites W2121993012 @default.
• W2798072540 cites W2126504345 @default.
• W2798072540 cites W2127133351 @default.
• W2798072540 cites W2131727615 @default.
• W2798072540 cites W2142140480 @default.
• W2798072540 cites W2142808072 @default.
• W2798072540 cites W2143778802 @default.
• W2798072540 cites W2147706925 @default.
• W2798072540 cites W2152744936 @default.
• W2798072540 cites W2165464537 @default.
• W2798072540 cites W2291541455 @default.
• W2798072540 cites W2335790828 @default.
• W2798072540 cites W2400828020 @default.
• W2798072540 cites W2531070838 @default.
• W2798072540 cites W2548952752 @default.
• W2798072540 cites W2606559317 @default.
• W2798072540 cites W2769660038 @default.
• W2798072540 cites W2788540728 @default.
• W2798072540 doi "https://doi.org/10.1080/21505594.2018.1460187" @default.
• W2798072540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5955468" @default.
• W2798072540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29638177" @default.
• W2798072540 hasPublicationYear "2018" @default.
• W2798072540 type Work @default.
• W2798072540 sameAs 2798072540 @default.
• W2798072540 citedByCount "36" @default.
• W2798072540 countsByYear W27980725402018 @default.
• W2798072540 countsByYear W27980725402019 @default.
• W2798072540 countsByYear W27980725402020 @default.
• W2798072540 countsByYear W27980725402021 @default.
• W2798072540 countsByYear W27980725402022 @default.
• W2798072540 countsByYear W27980725402023 @default.
• W2798072540 crossrefType "journal-article" @default.
• W2798072540 hasAuthorship W2798072540A5035389792 @default.
• W2798072540 hasAuthorship W2798072540A5055214609 @default.
• W2798072540 hasAuthorship W2798072540A5058862777 @default.
• W2798072540 hasAuthorship W2798072540A5076347067 @default.
• W2798072540 hasAuthorship W2798072540A5078163920 @default.
• W2798072540 hasAuthorship W2798072540A5087945181 @default.
• W2798072540 hasBestOaLocation W27980725401 @default.
• W2798072540 hasConcept C104317684 @default.
• W2798072540 hasConcept C127716648 @default.
• W2798072540 hasConcept C133936738 @default.
• W2798072540 hasConcept C203014093 @default.
• W2798072540 hasConcept C2776315533 @default.
• W2798072540 hasConcept C2777637488 @default.
• W2798072540 hasConcept C2778384902 @default.
• W2798072540 hasConcept C2778754761 @default.
• W2798072540 hasConcept C2779259085 @default.
• W2798072540 hasConcept C501593827 @default.
• W2798072540 hasConcept C523546767 @default.
• W2798072540 hasConcept C54355233 @default.
• W2798072540 hasConcept C58123911 @default.
• W2798072540 hasConcept C60987743 @default.
• W2798072540 hasConcept C86803240 @default.
• W2798072540 hasConcept C89423630 @default.
• W2798072540 hasConceptScore W2798072540C104317684 @default.
• W2798072540 hasConceptScore W2798072540C127716648 @default.
• W2798072540 hasConceptScore W2798072540C133936738 @default.
• W2798072540 hasConceptScore W2798072540C203014093 @default.
• W2798072540 hasConceptScore W2798072540C2776315533 @default.
• W2798072540 hasConceptScore W2798072540C2777637488 @default.
• W2798072540 hasConceptScore W2798072540C2778384902 @default.
• W2798072540 hasConceptScore W2798072540C2778754761 @default.
• W2798072540 hasConceptScore W2798072540C2779259085 @default.

• next