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- W2798094719 abstract "Adult chondrocytes experience a hypoxic environment in vivo. Culturing chondrocytes under oxygen tension that more closely resembles the in vivo situation, i.e. hypoxic conditions, has been shown to have positive effects on matrix synthesis. During redifferentiation of expanded chondrocytes, hypoxia increased collagen type II expression. However, the mechanism by which hypoxia enhances redifferentiation is still incompletely elucidated. We employed micro-bioreactor technology to elucidate the contribution of TGF-β superfamily ligands to the chondrocyte differentiation process under hypoxic conditions in vitro.Dedifferentiated chondrocytes in alginate were cultured for 48 hours under hypoxic (1% pO2) or normoxic (20%) conditions, using specialized bioreactor technology. Gene expression of chondrocyte-specific markers (SOX9, COL2A1, COL1A1, AGC1 and MMP13) as well as established hypoxia-controlled genes (GDF1-, PHD3, HAS2, VEGF, COX2) and components of the TGF-β superfamily signaling pathways were analyzed ..." @default.
- W2798094719 created "2018-04-24" @default.
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- W2798094719 date "2018-02-21" @default.
- W2798094719 modified "2023-09-24" @default.
- W2798094719 title "PRESERVATION OF CHONDROCYTE PHENOTYPE BY TGF-Β SUPERFAMILY MEMBERS UNDER HYPOXIA" @default.
- W2798094719 hasPublicationYear "2018" @default.
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