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- W2798118575 abstract "Biological motors are highly complex protein assemblies that generate linear or rotary motion, powered by chemical energy. Synthetic motors based on DNA nanostructures, bio-hybrid designs or synthetic organic chemistry have been assembled. However, unidirectionally rotating biomimetic wheel motors with rotor-stator units that consume chemical energy are elusive. Here, we report a bio-hybrid nanoengine consisting of a catalytic stator that unidirectionally rotates an interlocked DNA wheel, powered by NTP hydrolysis. The engine consists of an engineered T7 RNA polymerase (T7RNAP-ZIF) attached to a dsDNA nanoring that is catenated to a rigid rotating dsDNA wheel. The wheel motor produces long, repetitive RNA transcripts that remain attached to the engine and are used to guide its movement along predefined ssDNA tracks arranged on a DNA nanotube. The simplicity of the design renders this walking nanoengine adaptable to other biological nanoarchitectures, facilitating the construction of complex bio-hybrid structures that achieve NTP-driven locomotion." @default.
- W2798118575 created "2018-04-24" @default.
- W2798118575 creator A5049884091 @default.
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- W2798118575 date "2018-04-09" @default.
- W2798118575 modified "2023-10-05" @default.
- W2798118575 title "A bio-hybrid DNA rotor–stator nanoengine that moves along predefined tracks" @default.
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- W2798118575 doi "https://doi.org/10.1038/s41565-018-0109-z" @default.
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- W2798118575 hasPublicationYear "2018" @default.
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