Matches in SemOpenAlex for { <https://semopenalex.org/work/W2798119325> ?p ?o ?g. }
- W2798119325 endingPage "1731" @default.
- W2798119325 startingPage "1719" @default.
- W2798119325 abstract "Hierarchical micropore/nanorod-patterned strontium doped hydroxyapatite (Ca9Sr1(PO4)6(OH)2, Sr1-HA) structures (MNRs) with different nanorod diameters of about 30, 70 and 150 nm were coated on titanium, to investigate the effect of nanorod diameter on osteogenesis and the involved mechanism. Compared to micropore/nanogranule-patterned Sr1-HA coating (MNG), MNRs gave rise to dramatically enhanced in vitro mesenchymal stem cell functions including osteogenic differentiation in the absence of osteogenic supplements and in vivo osseointegration related to the nanorod diameter with about 70 nm displaying the best effects. MNRs activated the cellular Wnt/β-catenin pathway by increasing the expression of Wnt3a and LRP6 and decreasing the expression of Wnt/β-catenin pathway antagonists (sFRP1, sFRP2, Dkk1 and Dkk2). The exogenous Wnt3a significantly enhanced the β-catenin signaling activation and cell differentiation on MNG, and the exogenous Dkk1 attenuated the enhancing effect of MNRs on them. The data demonstrate that MNRs favor osseointegration via a Wnt/β-catenin pathway." @default.
- W2798119325 created "2018-04-24" @default.
- W2798119325 creator A5037446687 @default.
- W2798119325 creator A5073580278 @default.
- W2798119325 creator A5081525217 @default.
- W2798119325 creator A5083284087 @default.
- W2798119325 date "2018-07-01" @default.
- W2798119325 modified "2023-09-26" @default.
- W2798119325 title "Nanorod diameter modulated osteogenic activity of hierarchical micropore/nanorod-patterned coatings via a Wnt/β-catenin pathway" @default.
- W2798119325 cites W1835247210 @default.
- W2798119325 cites W1973615948 @default.
- W2798119325 cites W1982716000 @default.
- W2798119325 cites W1985786267 @default.
- W2798119325 cites W1987695360 @default.
- W2798119325 cites W1998839841 @default.
- W2798119325 cites W2009530445 @default.
- W2798119325 cites W2012293496 @default.
- W2798119325 cites W2014917824 @default.
- W2798119325 cites W2015600085 @default.
- W2798119325 cites W2021102901 @default.
- W2798119325 cites W2037998434 @default.
- W2798119325 cites W2047253804 @default.
- W2798119325 cites W2051870830 @default.
- W2798119325 cites W2052081749 @default.
- W2798119325 cites W2073375166 @default.
- W2798119325 cites W2074530707 @default.
- W2798119325 cites W2076783705 @default.
- W2798119325 cites W2082504241 @default.
- W2798119325 cites W2082841214 @default.
- W2798119325 cites W2095794163 @default.
- W2798119325 cites W2105402224 @default.
- W2798119325 cites W2112090160 @default.
- W2798119325 cites W2113402614 @default.
- W2798119325 cites W2121716178 @default.
- W2798119325 cites W2122236102 @default.
- W2798119325 cites W2132936019 @default.
- W2798119325 cites W2134873228 @default.
- W2798119325 cites W2137438672 @default.
- W2798119325 cites W2137617727 @default.
- W2798119325 cites W2142475480 @default.
- W2798119325 cites W2158938188 @default.
- W2798119325 cites W2169728933 @default.
- W2798119325 cites W2170773398 @default.
- W2798119325 cites W2289469305 @default.
- W2798119325 cites W2328033143 @default.
- W2798119325 cites W2516768073 @default.
- W2798119325 cites W2535966487 @default.
- W2798119325 cites W2565248680 @default.
- W2798119325 cites W2601594867 @default.
- W2798119325 cites W2619972925 @default.
- W2798119325 cites W2746406156 @default.
- W2798119325 doi "https://doi.org/10.1016/j.nano.2018.04.006" @default.
- W2798119325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29665441" @default.
- W2798119325 hasPublicationYear "2018" @default.
- W2798119325 type Work @default.
- W2798119325 sameAs 2798119325 @default.
- W2798119325 citedByCount "19" @default.
- W2798119325 countsByYear W27981193252019 @default.
- W2798119325 countsByYear W27981193252020 @default.
- W2798119325 countsByYear W27981193252021 @default.
- W2798119325 countsByYear W27981193252022 @default.
- W2798119325 countsByYear W27981193252023 @default.
- W2798119325 crossrefType "journal-article" @default.
- W2798119325 hasAuthorship W2798119325A5037446687 @default.
- W2798119325 hasAuthorship W2798119325A5073580278 @default.
- W2798119325 hasAuthorship W2798119325A5081525217 @default.
- W2798119325 hasAuthorship W2798119325A5083284087 @default.
- W2798119325 hasConcept C101414908 @default.
- W2798119325 hasConcept C12554922 @default.
- W2798119325 hasConcept C126201875 @default.
- W2798119325 hasConcept C137620995 @default.
- W2798119325 hasConcept C141071460 @default.
- W2798119325 hasConcept C159985019 @default.
- W2798119325 hasConcept C171250308 @default.
- W2798119325 hasConcept C185592680 @default.
- W2798119325 hasConcept C192562407 @default.
- W2798119325 hasConcept C198826908 @default.
- W2798119325 hasConcept C2777491412 @default.
- W2798119325 hasConcept C2779131293 @default.
- W2798119325 hasConcept C2781411149 @default.
- W2798119325 hasConcept C30145163 @default.
- W2798119325 hasConcept C55493867 @default.
- W2798119325 hasConcept C62478195 @default.
- W2798119325 hasConcept C71924100 @default.
- W2798119325 hasConcept C86381522 @default.
- W2798119325 hasConcept C86803240 @default.
- W2798119325 hasConcept C95444343 @default.
- W2798119325 hasConceptScore W2798119325C101414908 @default.
- W2798119325 hasConceptScore W2798119325C12554922 @default.
- W2798119325 hasConceptScore W2798119325C126201875 @default.
- W2798119325 hasConceptScore W2798119325C137620995 @default.
- W2798119325 hasConceptScore W2798119325C141071460 @default.
- W2798119325 hasConceptScore W2798119325C159985019 @default.
- W2798119325 hasConceptScore W2798119325C171250308 @default.
- W2798119325 hasConceptScore W2798119325C185592680 @default.
- W2798119325 hasConceptScore W2798119325C192562407 @default.
- W2798119325 hasConceptScore W2798119325C198826908 @default.
- W2798119325 hasConceptScore W2798119325C2777491412 @default.