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• W2798142502 startingPage "549" @default.
• W2798142502 abstract "Sulfolobus islandicus Rey15A encodes one Type I-A and two Type III-B systems, all of which are active in mediating nucleic acids interference. However, the effectiveness of each CRISPR system against virus infection was not tested in this archaeon. Here we constructed S. islandicus strains that constitutively express the antiviral immunity from either I-A, or III-B, or I-A plus III-B systems against SMV1 and tested the response of each host to SMV1 infection. We found that, although both CRISPR immunities showed a strong inhibition to viral DNA replication at an early stage of incubation, the host I-A CRISPR immunity gradually lost the control on virus proliferation, allowing accumulation of cellular viral DNA and release of a large number of viral particles. In contrast, the III-B CRISPR immunity showed a tight control on both viral DNA replication and virus particle formation. Furthermore, the SMV1 tolerance to the I-A CRISPR immunity did not result from the occurrence of escape mutations, suggesting the virus probably encodes an anti-CRISPR protein (Acr) to compromise the host I-A CRISPR immunity. Together, this suggests that the interplay between viral Acrs and CRISPR-Cas systems in thermophilic archaea could have shaped the stable virus-host relationship that is observed for many archaeal viruses." @default.
• W2798142502 created "2018-04-24" @default.
• W2798142502 creator A5031134036 @default.
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• W2798142502 date "2018-07-09" @default.
• W2798142502 modified "2023-09-23" @default.
• W2798142502 title "Tolerance of <i>Sulfolobus</i> SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in <i>Sulfolobus islandicus</i>" @default.
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• W2798142502 doi "https://doi.org/10.1080/15476286.2018.1460993" @default.
• W2798142502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546401" @default.
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• W2798142502 hasPublicationYear "2018" @default.
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