FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2798188082> ?p ?o ?g. }

• W2798188082 endingPage "1648" @default.
• W2798188082 startingPage "1636" @default.
• W2798188082 abstract "Background The high cardiovascular morbidity and mortality of patients with CKD may result in large part from medial vascular calcification, a process promoted by hyperphosphatemia and involving osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Reduced serum zinc levels have frequently been observed in patients with CKD, but the functional relevance of this remains unclear. Methods We performed experiments in primary human aortic VSMCs; klotho-hypomorphic ( kl/kl ), subtotal nephrectomy, and cholecalciferol-overload mouse calcification models; and serum samples from patients with CKD. Results In cultured VSMCs, treatment with zinc sulfate (ZnSO 4 ) blunted phosphate-induced calcification, osteo-/chondrogenic signaling, and NF- κ B activation. ZnSO 4 increased the abundance of zinc-finger protein TNF- α –induced protein 3 (TNFAIP3, also known as A20), a suppressor of the NF- κ B pathway, by zinc-sensing receptor ZnR/GPR39-dependent upregulation of TNFAIP3 gene expression. Silencing of TNFAIP3 in VSMCs blunted the anticalcific effects of ZnSO 4 under high phosphate conditions. kl/kl mice showed reduced plasma zinc levels, and ZnSO 4 supplementation strongly blunted vascular calcification and aortic osteoinduction and upregulated aortic Tnfaip3 expression. ZnSO 4 ameliorated vascular calcification in mice with chronic renal failure and mice with cholecalciferol overload. In patients with CKD, serum zinc concentrations inversely correlated with serum calcification propensity. Finally, ZnSO 4 ameliorated the osteoinductive effects of uremic serum in VSMCs. Conclusions Zinc supplementation ameliorates phosphate-induced osteo-/chondrogenic transdifferentiation of VSMCs and vascular calcification through an active cellular mechanism resulting from GPR39-dependent induction of TNFAIP3 and subsequent suppression of the NF- κ B pathway. Zinc supplementation may be a simple treatment to reduce the burden of vascular calcification in CKD." @default.
• W2798188082 created "2018-04-24" @default.
• W2798188082 creator A5000245503 @default.
• W2798188082 creator A5003317948 @default.
• W2798188082 creator A5004202808 @default.
• W2798188082 creator A5009905903 @default.
• W2798188082 creator A5011188514 @default.
• W2798188082 creator A5023493294 @default.
• W2798188082 creator A5033550812 @default.
• W2798188082 creator A5037466719 @default.
• W2798188082 creator A5046365487 @default.
• W2798188082 creator A5051718614 @default.
• W2798188082 creator A5057254396 @default.
• W2798188082 creator A5063109778 @default.
• W2798188082 creator A5070142597 @default.
• W2798188082 creator A5079510101 @default.
• W2798188082 creator A5084208566 @default.
• W2798188082 creator A5086517431 @default.
• W2798188082 creator A5090201226 @default.
• W2798188082 date "2018-04-13" @default.
• W2798188082 modified "2023-10-10" @default.
• W2798188082 title "Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB" @default.
• W2798188082 cites W1964927916 @default.
• W2798188082 cites W1968467043 @default.
• W2798188082 cites W1972451748 @default.
• W2798188082 cites W1974722726 @default.
• W2798188082 cites W2005837331 @default.
• W2798188082 cites W2008893552 @default.
• W2798188082 cites W2011779587 @default.
• W2798188082 cites W2012798783 @default.
• W2798188082 cites W2021662182 @default.
• W2798188082 cites W2027239388 @default.
• W2798188082 cites W2028218895 @default.
• W2798188082 cites W2028483223 @default.
• W2798188082 cites W2030174339 @default.
• W2798188082 cites W2033518661 @default.
• W2798188082 cites W2041098216 @default.
• W2798188082 cites W2049081002 @default.
• W2798188082 cites W2061046080 @default.
• W2798188082 cites W2067113440 @default.
• W2798188082 cites W2069331857 @default.
• W2798188082 cites W2070012006 @default.
• W2798188082 cites W2077031050 @default.
• W2798188082 cites W2083295260 @default.
• W2798188082 cites W2083448805 @default.
• W2798188082 cites W2086165182 @default.
• W2798188082 cites W2094189954 @default.
• W2798188082 cites W2095788226 @default.
• W2798188082 cites W2101403851 @default.
• W2798188082 cites W2101888385 @default.
• W2798188082 cites W2102235351 @default.
• W2798188082 cites W2106975101 @default.
• W2798188082 cites W2135808088 @default.
• W2798188082 cites W2136628690 @default.
• W2798188082 cites W2139675687 @default.
• W2798188082 cites W2155088148 @default.
• W2798188082 cites W2158561625 @default.
• W2798188082 cites W2162625952 @default.
• W2798188082 cites W2165291356 @default.
• W2798188082 cites W2166199725 @default.
• W2798188082 cites W2171303601 @default.
• W2798188082 cites W2181175772 @default.
• W2798188082 cites W2280169046 @default.
• W2798188082 cites W2311465732 @default.
• W2798188082 cites W2333983113 @default.
• W2798188082 cites W2337202407 @default.
• W2798188082 cites W2467948653 @default.
• W2798188082 cites W2520768054 @default.
• W2798188082 cites W2524064036 @default.
• W2798188082 cites W2560519247 @default.
• W2798188082 cites W2564838817 @default.
• W2798188082 cites W2578652655 @default.
• W2798188082 doi "https://doi.org/10.1681/asn.2017050492" @default.
• W2798188082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6054342" @default.
• W2798188082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29654213" @default.
• W2798188082 hasPublicationYear "2018" @default.
• W2798188082 type Work @default.
• W2798188082 sameAs 2798188082 @default.
• W2798188082 citedByCount "95" @default.
• W2798188082 countsByYear W27981880822018 @default.
• W2798188082 countsByYear W27981880822019 @default.
• W2798188082 countsByYear W27981880822020 @default.
• W2798188082 countsByYear W27981880822021 @default.
• W2798188082 countsByYear W27981880822022 @default.
• W2798188082 countsByYear W27981880822023 @default.
• W2798188082 crossrefType "journal-article" @default.
• W2798188082 hasAuthorship W2798188082A5000245503 @default.
• W2798188082 hasAuthorship W2798188082A5003317948 @default.
• W2798188082 hasAuthorship W2798188082A5004202808 @default.
• W2798188082 hasAuthorship W2798188082A5009905903 @default.
• W2798188082 hasAuthorship W2798188082A5011188514 @default.
• W2798188082 hasAuthorship W2798188082A5023493294 @default.
• W2798188082 hasAuthorship W2798188082A5033550812 @default.
• W2798188082 hasAuthorship W2798188082A5037466719 @default.
• W2798188082 hasAuthorship W2798188082A5046365487 @default.
• W2798188082 hasAuthorship W2798188082A5051718614 @default.
• W2798188082 hasAuthorship W2798188082A5057254396 @default.
• W2798188082 hasAuthorship W2798188082A5063109778 @default.

• next