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- W27984013 abstract "markdownabstract__Abstract__In this thesis, author systematically studied two testis-specific protein kinases TSSK1 and TSSK2 in mouse spermiogenesis. By building a double knockout mouse model with the absence of Tssk1 and Tssk2 genes, it was demonstratedthat TSSK1 and TSSK2 are essential for male fertility in mouse, and the homozygousmale mutants missing these two kinases are infertile. In addition, TSSK1 and TSSK2, together with their common substrate, TSKS, are involved into the chromatoid body (CB) transformation during spermatid elongation. By co-IP and following proteomics analyses, it was shown that TSSK1, TSSK2, and TSKS can form a stable protein complex, named as TSSK1/2-TSKS complex, which is involved into RNA regulation, protein phorsphorylation and cytoskeleton regulation. Further evolutionary studies displayed that TSSK1 and TSSK2 gained diverse functions during evolution, although Tssk1 and Tssk2 are a pair of duplicated genes, and TSSK1 and TSSK2 are highly homologous. Because of the testis-specificty, late expression, and the indispensability to male fertility, TSSK1and TSSK2 are potential drug targets for non-hormonal contraceptives" @default.
- W27984013 created "2016-06-24" @default.
- W27984013 creator A5084856558 @default.
- W27984013 date "2014-12-09" @default.
- W27984013 modified "2023-09-28" @default.
- W27984013 title "Testis-specific Protein Kinases TSSK1 and TSSK2 in Mouse Spermiogenesis" @default.
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