FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2798456210> ?p ?o ?g. }

• W2798456210 endingPage "e1007159" @default.
• W2798456210 startingPage "e1007159" @default.
• W2798456210 abstract "Eliciting broadly neutralizing antibodies (bnAbs) targeting envelope (Env) is a major goal of HIV vaccine development, but cross-clade breadth from immunization has only sporadically been observed. Recently, Xu et al (2018) elicited cross-reactive neutralizing antibody responses in a variety of animal models using immunogens based on the epitope of bnAb VRC34.01. The VRC34.01 antibody, which was elicited by natural human infection, targets the N terminus of the Env fusion peptide, a critical component of the virus entry machinery. Here we precisely characterize the functional epitopes of VRC34.01 and two vaccine-elicited murine antibodies by mapping all single amino-acid mutations to the BG505 Env that affect viral neutralization. While escape from VRC34.01 occurred via mutations in both fusion peptide and distal interacting sites of the Env trimer, escape from the vaccine-elicited antibodies was mediated predominantly by mutations in the fusion peptide. Cryo-electron microscopy of four vaccine-elicited antibodies in complex with Env trimer revealed focused recognition of the fusion peptide and provided a structural basis for development of neutralization breadth. Together, these functional and structural data suggest that the breadth of vaccine-elicited antibodies targeting the fusion peptide can be enhanced by specific interactions with additional portions of Env. Thus, our complete maps of viral escape both delineate pathways of resistance to these fusion peptide-directed antibodies and provide a strategy to improve the breadth or potency of future vaccine-induced antibodies against Env’s fusion peptide." @default.
• W2798456210 created "2018-05-07" @default.
• W2798456210 creator A5000868484 @default.
• W2798456210 creator A5012251819 @default.
• W2798456210 creator A5032473193 @default.
• W2798456210 creator A5042543645 @default.
• W2798456210 creator A5042940595 @default.
• W2798456210 creator A5043677118 @default.
• W2798456210 creator A5046815472 @default.
• W2798456210 creator A5053998664 @default.
• W2798456210 creator A5056683217 @default.
• W2798456210 creator A5058127394 @default.
• W2798456210 creator A5069049986 @default.
• W2798456210 creator A5071657202 @default.
• W2798456210 creator A5075328638 @default.
• W2798456210 creator A5089740833 @default.
• W2798456210 date "2018-07-05" @default.
• W2798456210 modified "2023-09-30" @default.
• W2798456210 title "Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV" @default.
• W2798456210 cites W1794879226 @default.
• W2798456210 cites W1838872057 @default.
• W2798456210 cites W1972341594 @default.
• W2798456210 cites W1992529182 @default.
• W2798456210 cites W2028470175 @default.
• W2798456210 cites W2029135056 @default.
• W2798456210 cites W2046563994 @default.
• W2798456210 cites W2058368107 @default.
• W2798456210 cites W2076449818 @default.
• W2798456210 cites W2104234755 @default.
• W2798456210 cites W2121527455 @default.
• W2798456210 cites W2122210861 @default.
• W2798456210 cites W2132629607 @default.
• W2798456210 cites W2133204396 @default.
• W2798456210 cites W2134216529 @default.
• W2798456210 cites W2138875004 @default.
• W2798456210 cites W2144081223 @default.
• W2798456210 cites W2150687797 @default.
• W2798456210 cites W2158266834 @default.
• W2798456210 cites W2161661741 @default.
• W2798456210 cites W2230190738 @default.
• W2798456210 cites W2380132702 @default.
• W2798456210 cites W2409271617 @default.
• W2798456210 cites W2409722811 @default.
• W2798456210 cites W2554071243 @default.
• W2798456210 cites W2564237271 @default.
• W2798456210 cites W2581575342 @default.
• W2798456210 cites W2585038741 @default.
• W2798456210 cites W2587625522 @default.
• W2798456210 cites W2620965804 @default.
• W2798456210 cites W2737196618 @default.
• W2798456210 cites W2781609628 @default.
• W2798456210 cites W2782613909 @default.
• W2798456210 cites W2799119185 @default.
• W2798456210 cites W2949415981 @default.
• W2798456210 cites W2950782282 @default.
• W2798456210 cites W2950967305 @default.
• W2798456210 doi "https://doi.org/10.1371/journal.ppat.1007159" @default.
• W2798456210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6049957" @default.
• W2798456210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29975771" @default.
• W2798456210 hasPublicationYear "2018" @default.
• W2798456210 type Work @default.
• W2798456210 sameAs 2798456210 @default.
• W2798456210 citedByCount "41" @default.
• W2798456210 countsByYear W27984562102018 @default.
• W2798456210 countsByYear W27984562102019 @default.
• W2798456210 countsByYear W27984562102020 @default.
• W2798456210 countsByYear W27984562102021 @default.
• W2798456210 countsByYear W27984562102022 @default.
• W2798456210 countsByYear W27984562102023 @default.
• W2798456210 crossrefType "journal-article" @default.
• W2798456210 hasAuthorship W2798456210A5000868484 @default.
• W2798456210 hasAuthorship W2798456210A5012251819 @default.
• W2798456210 hasAuthorship W2798456210A5032473193 @default.
• W2798456210 hasAuthorship W2798456210A5042543645 @default.
• W2798456210 hasAuthorship W2798456210A5042940595 @default.
• W2798456210 hasAuthorship W2798456210A5043677118 @default.
• W2798456210 hasAuthorship W2798456210A5046815472 @default.
• W2798456210 hasAuthorship W2798456210A5053998664 @default.
• W2798456210 hasAuthorship W2798456210A5056683217 @default.
• W2798456210 hasAuthorship W2798456210A5058127394 @default.
• W2798456210 hasAuthorship W2798456210A5069049986 @default.
• W2798456210 hasAuthorship W2798456210A5071657202 @default.
• W2798456210 hasAuthorship W2798456210A5075328638 @default.
• W2798456210 hasAuthorship W2798456210A5089740833 @default.
• W2798456210 hasBestOaLocation W27984562101 @default.
• W2798456210 hasConcept C104317684 @default.
• W2798456210 hasConcept C140704245 @default.
• W2798456210 hasConcept C14086860 @default.
• W2798456210 hasConcept C159047783 @default.
• W2798456210 hasConcept C159654299 @default.
• W2798456210 hasConcept C167625842 @default.
• W2798456210 hasConcept C195616568 @default.
• W2798456210 hasConcept C203014093 @default.
• W2798456210 hasConcept C2522874641 @default.
• W2798456210 hasConcept C2776789287 @default.
• W2798456210 hasConcept C2778190748 @default.
• W2798456210 hasConcept C2779261636 @default.
• W2798456210 hasConcept C2779281246 @default.

• next