FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2798947321> ?p ?o ?g. }

• W2798947321 abstract "18F-fluoroethyl-SPA-RQ (18F-FE-SPA-RQ) was recently developed asa radioligand for the measurement of neurokinin1 (NK1)receptor with PET. In this study, we used 18F-FE-SPA-RQ withPET to visualize and quantify NK1 receptor in the human brain. Methods: PETscanswereperformedon7healthymenafterintravenousinjection of 18 F-FE-SPA-RQ. Binding potential (BPND) was calculated by theindirectkinetic,simplifiedreferencetissuemodel(SRTM),andratiomethods.Theindirectkineticmethodwasusedasthegoldstandard method and was comparedwith the SRTMmethod, withscan timesof180, 270,and330min, and withthe ratiomethod, withtime integration intervals of 120‐180, 210‐270, and 300‐330 min. The cerebellum was used as the reference brain region. Results: Regional radioactivity was highest in the caudate head and putamen; mid level in the parahippocampus, cerebral cortex, and thalamus; and lowest in the cerebellum. BPND values by the indirect kinetic method were 3.15 6 0.36, 3.11 6 0.66, 1.17 6 0.25, and 0.46 6 0.14 in the caudate, putamen, parahippocampal region, and thalamus, respectively. For cerebral cortical regions, BPND values by the indirect kinetic method were 0.94 6 0.23, 0.82 6 0.15, 0.76 6 0.15, and 0.69 6 0.16 in the occipital, temporal, frontal, and anterior cingulate cortices, respectively. BPND values by the SRTM and ratio methods were in good agreement with those by the indirect kinetic method (r 5 0.94‐0.98). Conclusion: The regional distribution of 18 F-FE-SPA-RQ was in agreement w ith previous PET studies and postmortem studies of NK1 receptor in the human brain. The ratio method will be useful for clinical research of psychiatric disorders, for the estimation of NK1 receptor without arterial blood sampling and long dynamic PET." @default.
• W2798947321 created "2018-05-07" @default.
• W2798947321 creator A5001747141 @default.
• W2798947321 creator A5026216076 @default.
• W2798947321 creator A5026948578 @default.
• W2798947321 creator A5031416330 @default.
• W2798947321 creator A5033868555 @default.
• W2798947321 creator A5040395664 @default.
• W2798947321 creator A5040707611 @default.
• W2798947321 creator A5058646333 @default.
• W2798947321 creator A5060847562 @default.
• W2798947321 creator A5076133971 @default.
• W2798947321 creator A5085556975 @default.
• W2798947321 creator A5086525882 @default.
• W2798947321 date "2008-01-01" @default.
• W2798947321 modified "2023-09-23" @default.
• W2798947321 title "Quantitative Analysis of NK 1 Receptor in the Human Brain Using PET with 18 F-FE-SPA-RQ" @default.
• W2798947321 cites W1530868743 @default.
• W2798947321 cites W154326007 @default.
• W2798947321 cites W1568101899 @default.
• W2798947321 cites W1968142570 @default.
• W2798947321 cites W1977252507 @default.
• W2798947321 cites W1980839404 @default.
• W2798947321 cites W1984754203 @default.
• W2798947321 cites W1985098185 @default.
• W2798947321 cites W2002763100 @default.
• W2798947321 cites W2003404396 @default.
• W2798947321 cites W2005530101 @default.
• W2798947321 cites W2018968319 @default.
• W2798947321 cites W2019261140 @default.
• W2798947321 cites W2032050844 @default.
• W2798947321 cites W2044233135 @default.
• W2798947321 cites W2045030807 @default.
• W2798947321 cites W2055505440 @default.
• W2798947321 cites W2063593286 @default.
• W2798947321 cites W2079052515 @default.
• W2798947321 cites W2083670498 @default.
• W2798947321 cites W2093225726 @default.
• W2798947321 cites W2094143976 @default.
• W2798947321 cites W2112278807 @default.
• W2798947321 cites W2117671988 @default.
• W2798947321 cites W2128040637 @default.
• W2798947321 cites W2131280004 @default.
• W2798947321 cites W2140799285 @default.
• W2798947321 cites W2159348568 @default.
• W2798947321 cites W2164512116 @default.
• W2798947321 cites W2165395427 @default.
• W2798947321 cites W2282248868 @default.
• W2798947321 hasPublicationYear "2008" @default.
• W2798947321 type Work @default.
• W2798947321 sameAs 2798947321 @default.
• W2798947321 citedByCount "0" @default.
• W2798947321 crossrefType "journal-article" @default.
• W2798947321 hasAuthorship W2798947321A5001747141 @default.
• W2798947321 hasAuthorship W2798947321A5026216076 @default.
• W2798947321 hasAuthorship W2798947321A5026948578 @default.
• W2798947321 hasAuthorship W2798947321A5031416330 @default.
• W2798947321 hasAuthorship W2798947321A5033868555 @default.
• W2798947321 hasAuthorship W2798947321A5040395664 @default.
• W2798947321 hasAuthorship W2798947321A5040707611 @default.
• W2798947321 hasAuthorship W2798947321A5058646333 @default.
• W2798947321 hasAuthorship W2798947321A5060847562 @default.
• W2798947321 hasAuthorship W2798947321A5076133971 @default.
• W2798947321 hasAuthorship W2798947321A5085556975 @default.
• W2798947321 hasAuthorship W2798947321A5086525882 @default.
• W2798947321 hasConcept C121332964 @default.
• W2798947321 hasConcept C126322002 @default.
• W2798947321 hasConcept C126838900 @default.
• W2798947321 hasConcept C134018914 @default.
• W2798947321 hasConcept C15744967 @default.
• W2798947321 hasConcept C169760540 @default.
• W2798947321 hasConcept C170493617 @default.
• W2798947321 hasConcept C185592680 @default.
• W2798947321 hasConcept C2775842073 @default.
• W2798947321 hasConcept C2777348757 @default.
• W2798947321 hasConcept C2777670902 @default.
• W2798947321 hasConcept C2778733324 @default.
• W2798947321 hasConcept C2779246727 @default.
• W2798947321 hasConcept C2779652256 @default.
• W2798947321 hasConcept C2779714222 @default.
• W2798947321 hasConcept C2989005 @default.
• W2798947321 hasConcept C46141821 @default.
• W2798947321 hasConcept C60592354 @default.
• W2798947321 hasConcept C67847695 @default.
• W2798947321 hasConcept C71924100 @default.
• W2798947321 hasConceptScore W2798947321C121332964 @default.
• W2798947321 hasConceptScore W2798947321C126322002 @default.
• W2798947321 hasConceptScore W2798947321C126838900 @default.
• W2798947321 hasConceptScore W2798947321C134018914 @default.
• W2798947321 hasConceptScore W2798947321C15744967 @default.
• W2798947321 hasConceptScore W2798947321C169760540 @default.
• W2798947321 hasConceptScore W2798947321C170493617 @default.
• W2798947321 hasConceptScore W2798947321C185592680 @default.
• W2798947321 hasConceptScore W2798947321C2775842073 @default.
• W2798947321 hasConceptScore W2798947321C2777348757 @default.
• W2798947321 hasConceptScore W2798947321C2777670902 @default.
• W2798947321 hasConceptScore W2798947321C2778733324 @default.
• W2798947321 hasConceptScore W2798947321C2779246727 @default.
• W2798947321 hasConceptScore W2798947321C2779652256 @default.
• W2798947321 hasConceptScore W2798947321C2779714222 @default.

• next