FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2798983208> ?p ?o ?g. }

• W2798983208 endingPage "173" @default.
• W2798983208 startingPage "162" @default.
• W2798983208 abstract "Alpha-synuclein ( -syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in -syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson’s disease (PD). The physiological functions of -syn remain to be fully defined, although recent data suggest a role in regulating membrane stability and neuronal plasticity. Various trigger factors, either environmental or genetic, can lead to a cascade of events involving misfolding or loss of normal function of -syn. In dopaminergic neurons, this may promote a vicious cycle in which elevation in cytoplasmic dopamine, oxidative stress, -syn dysfunction, and disruption of vesicle function lead to dopaminergic cell loss and PD. -Syn dysfunction appears to be a common feature of all forms of PD. The mechanism by which -syn induces neuronal cell toxicity may invoke multiple pathways, such as aggregation or interaction with other proteins and molecules, including synphilin-1, chaperone 14-3-3 protein, and dopamine itself. This complexity has hindered the development of models to study PD. The available animal models of PD, each present distinct advantages and limits. Findings to date suggest that -syn-based models represent a paradigm, which is closest to the human pathology.— Recchia, A., Debetto, P., Negro, A., Guidolin, D., Skaper, S. D., Giusti, P. -Synuclein and Parkinson’s disease. FASEB J. 18, 617–626 (2004)" @default.
• W2798983208 created "2018-05-07" @default.
• W2798983208 creator A5006221519 @default.
• W2798983208 creator A5008046222 @default.
• W2798983208 creator A5021059428 @default.
• W2798983208 creator A5029940869 @default.
• W2798983208 creator A5044060284 @default.
• W2798983208 creator A5067183713 @default.
• W2798983208 date "2012-10-09" @default.
• W2798983208 modified "2023-09-24" @default.
• W2798983208 title "- α-Synuclein and Parkinson’s Disease" @default.
• W2798983208 cites W1485683953 @default.
• W2798983208 cites W1496790952 @default.
• W2798983208 cites W1502902982 @default.
• W2798983208 cites W1514910213 @default.
• W2798983208 cites W1521854746 @default.
• W2798983208 cites W1527671059 @default.
• W2798983208 cites W1529474377 @default.
• W2798983208 cites W1530609782 @default.
• W2798983208 cites W1540436551 @default.
• W2798983208 cites W1618846043 @default.
• W2798983208 cites W1811548175 @default.
• W2798983208 cites W1824123796 @default.
• W2798983208 cites W1900066504 @default.
• W2798983208 cites W1923453730 @default.
• W2798983208 cites W1935894920 @default.
• W2798983208 cites W1964910777 @default.
• W2798983208 cites W1971300927 @default.
• W2798983208 cites W1972601084 @default.
• W2798983208 cites W1974361709 @default.
• W2798983208 cites W1976345822 @default.
• W2798983208 cites W1979696767 @default.
• W2798983208 cites W1983632956 @default.
• W2798983208 cites W1986625112 @default.
• W2798983208 cites W1990726987 @default.
• W2798983208 cites W1991691390 @default.
• W2798983208 cites W1999159261 @default.
• W2798983208 cites W2002506451 @default.
• W2798983208 cites W2003405109 @default.
• W2798983208 cites W2007477251 @default.
• W2798983208 cites W2009556855 @default.
• W2798983208 cites W2013313629 @default.
• W2798983208 cites W2015352863 @default.
• W2798983208 cites W2018429553 @default.
• W2798983208 cites W2018481846 @default.
• W2798983208 cites W2020351832 @default.
• W2798983208 cites W2020676198 @default.
• W2798983208 cites W2020796799 @default.
• W2798983208 cites W2021224973 @default.
• W2798983208 cites W2021977313 @default.
• W2798983208 cites W2023245921 @default.
• W2798983208 cites W2032797457 @default.
• W2798983208 cites W2035075120 @default.
• W2798983208 cites W2035661230 @default.
• W2798983208 cites W2036423396 @default.
• W2798983208 cites W2038780437 @default.
• W2798983208 cites W2046014998 @default.
• W2798983208 cites W2046127729 @default.
• W2798983208 cites W2047176619 @default.
• W2798983208 cites W2047206971 @default.
• W2798983208 cites W2048570076 @default.
• W2798983208 cites W2049147398 @default.
• W2798983208 cites W2050167305 @default.
• W2798983208 cites W2050786534 @default.
• W2798983208 cites W2050972526 @default.
• W2798983208 cites W2051382732 @default.
• W2798983208 cites W2058137293 @default.
• W2798983208 cites W2059261643 @default.
• W2798983208 cites W206131021 @default.
• W2798983208 cites W2068602144 @default.
• W2798983208 cites W2069632588 @default.
• W2798983208 cites W2071243806 @default.
• W2798983208 cites W2073235926 @default.
• W2798983208 cites W2074649216 @default.
• W2798983208 cites W2075997185 @default.
• W2798983208 cites W2076344205 @default.
• W2798983208 cites W2082214510 @default.
• W2798983208 cites W2083084859 @default.
• W2798983208 cites W2083854431 @default.
• W2798983208 cites W2085209755 @default.
• W2798983208 cites W2086857730 @default.
• W2798983208 cites W2087848764 @default.
• W2798983208 cites W2091265794 @default.
• W2798983208 cites W2093131325 @default.
• W2798983208 cites W2093269765 @default.
• W2798983208 cites W2104382960 @default.
• W2798983208 cites W2107451956 @default.
• W2798983208 cites W2107658086 @default.
• W2798983208 cites W2109452908 @default.
• W2798983208 cites W2116819366 @default.
• W2798983208 cites W2116876598 @default.
• W2798983208 cites W2120867735 @default.
• W2798983208 cites W2122772601 @default.
• W2798983208 cites W2123571077 @default.
• W2798983208 cites W2123781000 @default.
• W2798983208 cites W2126326932 @default.
• W2798983208 cites W2130323165 @default.
• W2798983208 cites W2130909876 @default.

• next