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- W2798990556 abstract "All living systems can function only far away from equilibrium, and for this reason chemical kinetic methods are critically important for uncovering the mechanisms of biological processes. Here we present a new theoretical method of investigating dynamics of protein-DNA interactions, which govern all major biological processes. It is based on a first-passage analysis of biochemical and biophysical transitions, and it provides a fully analytic description of the processes. Our approach is explained for the case of a single protein searching for a specific binding site on DNA. In addition, the application of the method to investigations of the effect of DNA sequence heterogeneity, and the role multiple targets and traps in the protein search dynamics are discussed." @default.
- W2798990556 created "2018-05-07" @default.
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- W2798990556 date "2019-09-01" @default.
- W2798990556 modified "2023-10-14" @default.
- W2798990556 title "Kinetics of Protein–DNA Interactions: First-Passage Analysis" @default.
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- W2798990556 doi "https://doi.org/10.1142/9781786347015_0019" @default.
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