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- W2799210941 abstract "The motion of large molecules in microfluidic flows is important because the trajectories of particles in shear flows do not always follow the local flow field. Therefore, a knowledge of the fluid dynamics is not sufficient to completely describe the motion of the particles. When a suspended particle does not track the flow, the particle is said to be active as opposed to passive. The dynamics of active particles are particularly interesting in microfluidic devices because the molecules of polymer chains can approach – and even exceed – the characteristic lengths of the device. Consequently, the deviations between the particle/molecular motion and the fluid motion can be significant. While active particle dynamics can address the motion of any suspended particle in a fluid, microfluidic researchers are usually interested in polymer chains because these structures in general do not follow the fluid flow, have a high degree of flexibility, and model important biological subsystems such as DNA and many types of proteins. If we want to track or manipulate different polymer chains in a microfluidic system, we need to understand their dynamics relative to the fluid flow. However, not only will the bulk motion deviate from what the fluid is doing, but also their conformation or shape can change, which alters the transport properties. In other words, as polymer chains travel in a fluid system, the inherent flexibility of the chains allows them to bunch up, stretch out, or tumble in the flow. As the shape of the chain changes, the fluid forces imposed on the chain will also change. As a result, the motion of a flexible chain will vary even if the flow field remains constant. For microfluidic systems designed to sequence or hybridize DNA, for example, the conformation can be as important as the trajectory of bulk motion of the molecule." @default.
- W2799210941 created "2018-05-07" @default.
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- W2799210941 date "2011-08-29" @default.
- W2799210941 modified "2023-09-24" @default.
- W2799210941 title "Simulating Migration of Polymer Chains, Methods" @default.
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- W2799210941 doi "https://doi.org/10.1007/springerreference_67647" @default.
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