FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799213040> ?p ?o ?g. }

• W2799213040 abstract "Abstract Several biological functions are carried out via complexes that are formed via multimerization of either a single species (homomers) or multiple species (heteromers). Given functional relevance of these complexes, it is arguably desired to maintain their level at a set point and minimize fluctuations around it. Here we consider two simple models of complex formation – one for homomer and another for heteromer of two species – and analyze how important model parameters affect the noise in complex level. In particular, we study effects of (i) sensitivity of the complex formation rate with respect to constituting species’ abundance, and (ii) relative stability of the complex as compared with that of the constituents. By employing an approximate moment analysis, we find that for a given steady state level, there is an optimal sensitivity that minimizes noise (quantified by fano-factor; variance/mean) in the complex level. Furthermore, the noise becomes smaller if the complex is less stable than its constituents. Finally, for the heteromer case, our findings show that noise is enhanced if the complex is comparatively more sensitive to one constituent. We briefly discuss implications of our result for general complex formation processes." @default.
• W2799213040 created "2018-05-07" @default.
• W2799213040 creator A5021877590 @default.
• W2799213040 creator A5022267407 @default.
• W2799213040 creator A5075938156 @default.
• W2799213040 date "2018-05-01" @default.
• W2799213040 modified "2023-09-24" @default.
• W2799213040 title "Noise Analysis in Biochemical Complex Formation" @default.
• W2799213040 cites W1569416853 @default.
• W2799213040 cites W1669686402 @default.
• W2799213040 cites W1679051047 @default.
• W2799213040 cites W1973960290 @default.
• W2799213040 cites W1982186905 @default.
• W2799213040 cites W2007740207 @default.
• W2799213040 cites W2017453585 @default.
• W2799213040 cites W2018450278 @default.
• W2799213040 cites W2037036397 @default.
• W2799213040 cites W2053460598 @default.
• W2799213040 cites W2054908452 @default.
• W2799213040 cites W2061777334 @default.
• W2799213040 cites W2073094004 @default.
• W2799213040 cites W2079658191 @default.
• W2799213040 cites W2112175922 @default.
• W2799213040 cites W2125620011 @default.
• W2799213040 cites W2133297762 @default.
• W2799213040 cites W2141021005 @default.
• W2799213040 cites W2142221037 @default.
• W2799213040 cites W2144801144 @default.
• W2799213040 cites W2147556100 @default.
• W2799213040 cites W2148554623 @default.
• W2799213040 cites W2153624566 @default.
• W2799213040 cites W2155202381 @default.
• W2799213040 cites W2163017852 @default.
• W2799213040 cites W2466176229 @default.
• W2799213040 cites W2727980082 @default.
• W2799213040 cites W2739418797 @default.
• W2799213040 doi "https://doi.org/10.1101/310847" @default.
• W2799213040 hasPublicationYear "2018" @default.
• W2799213040 type Work @default.
• W2799213040 sameAs 2799213040 @default.
• W2799213040 citedByCount "0" @default.
• W2799213040 crossrefType "posted-content" @default.
• W2799213040 hasAuthorship W2799213040A5021877590 @default.
• W2799213040 hasAuthorship W2799213040A5022267407 @default.
• W2799213040 hasAuthorship W2799213040A5075938156 @default.
• W2799213040 hasBestOaLocation W27992130401 @default.
• W2799213040 hasConcept C112972136 @default.
• W2799213040 hasConcept C115961682 @default.
• W2799213040 hasConcept C119857082 @default.
• W2799213040 hasConcept C121332964 @default.
• W2799213040 hasConcept C121864883 @default.
• W2799213040 hasConcept C127413603 @default.
• W2799213040 hasConcept C154945302 @default.
• W2799213040 hasConcept C177264268 @default.
• W2799213040 hasConcept C179254644 @default.
• W2799213040 hasConcept C185592680 @default.
• W2799213040 hasConcept C186060115 @default.
• W2799213040 hasConcept C199360897 @default.
• W2799213040 hasConcept C21200559 @default.
• W2799213040 hasConcept C24326235 @default.
• W2799213040 hasConcept C41008148 @default.
• W2799213040 hasConcept C74650414 @default.
• W2799213040 hasConcept C86803240 @default.
• W2799213040 hasConcept C99498987 @default.
• W2799213040 hasConceptScore W2799213040C112972136 @default.
• W2799213040 hasConceptScore W2799213040C115961682 @default.
• W2799213040 hasConceptScore W2799213040C119857082 @default.
• W2799213040 hasConceptScore W2799213040C121332964 @default.
• W2799213040 hasConceptScore W2799213040C121864883 @default.
• W2799213040 hasConceptScore W2799213040C127413603 @default.
• W2799213040 hasConceptScore W2799213040C154945302 @default.
• W2799213040 hasConceptScore W2799213040C177264268 @default.
• W2799213040 hasConceptScore W2799213040C179254644 @default.
• W2799213040 hasConceptScore W2799213040C185592680 @default.
• W2799213040 hasConceptScore W2799213040C186060115 @default.
• W2799213040 hasConceptScore W2799213040C199360897 @default.
• W2799213040 hasConceptScore W2799213040C21200559 @default.
• W2799213040 hasConceptScore W2799213040C24326235 @default.
• W2799213040 hasConceptScore W2799213040C41008148 @default.
• W2799213040 hasConceptScore W2799213040C74650414 @default.
• W2799213040 hasConceptScore W2799213040C86803240 @default.
• W2799213040 hasConceptScore W2799213040C99498987 @default.
• W2799213040 hasLocation W27992130401 @default.
• W2799213040 hasOpenAccess W2799213040 @default.
• W2799213040 hasPrimaryLocation W27992130401 @default.
• W2799213040 hasRelatedWork W1972711846 @default.
• W2799213040 hasRelatedWork W1984782005 @default.
• W2799213040 hasRelatedWork W2025839341 @default.
• W2799213040 hasRelatedWork W2055152043 @default.
• W2799213040 hasRelatedWork W2058416357 @default.
• W2799213040 hasRelatedWork W2077854862 @default.
• W2799213040 hasRelatedWork W2107477147 @default.
• W2799213040 hasRelatedWork W2126862561 @default.
• W2799213040 hasRelatedWork W2127158191 @default.
• W2799213040 hasRelatedWork W2242954075 @default.
• W2799213040 hasRelatedWork W2468376328 @default.
• W2799213040 hasRelatedWork W2539358037 @default.
• W2799213040 hasRelatedWork W2587684247 @default.
• W2799213040 hasRelatedWork W2744309759 @default.
• W2799213040 hasRelatedWork W2759251458 @default.

• next