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• W2799286435 abstract "Corticosteroids increase the expression of β2-adrenoceptors (β2-ARs) and protect them against down-regulation. Conversely, β2-AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it is still uncertain whether adding a long-acting β2-AR agonist (LABA) to an inhaled corticosteroid (ICS) results in an additive effect, or there is true synergy. Therefore, the aim of this study was to pharmacologically characterize the interaction between the ICS beclomethasone diproprionate (BDP) and the LABA formoterol fumarate (FF) in a validated human ex vivo model of bronchial asthma.Human medium and small airways were stimulated by histamine and treated with different concentrations of BDP and FF, administered alone and in combination at concentration-ratio reproducing ex vivo that of the currently available fixed-dose combination (FDC; BDP/FF 100:6 combination-ratio). Experiments were performed in non-sensitized (NS) and passively sensitized (PS) airways. The pharmacological interaction was assessed by using Bliss Independence and Unified Theory equations.BDP/FF synergistically increased the overall bronchorelaxation in NS and PS airways (+ 15.15% ± 4.02%; P < 0.05 vs. additive effect). At low-to-medium concentrations the synergistic interaction was greater in PS than in NS bronchioles (+ 16.68% ± 3.02% and + 7.27% ± 3.05%, respectively). In PS small airways a very strong synergistic interaction (Combination Index: 0.08; + 20.04% ± 2.18% vs. additive effect) was detected for the total concentrations of BDP/FF combination corresponding to 10.6 ng/ml.BDP/FF combination synergistically relaxed human bronchi; the extent of such an interaction was very strong at low-to-medium concentrations in PS small airways.Not applicable." @default.
• W2799286435 created "2018-05-17" @default.
• W2799286435 creator A5035810516 @default.
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• W2799286435 creator A5060089859 @default.
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• W2799286435 creator A5081405874 @default.
• W2799286435 date "2018-04-12" @default.
• W2799286435 modified "2023-10-18" @default.
• W2799286435 title "Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airways" @default.
• W2799286435 cites W1519188036 @default.
• W2799286435 cites W1538884896 @default.
• W2799286435 cites W1580672741 @default.
• W2799286435 cites W1666751696 @default.
• W2799286435 cites W1823510477 @default.
• W2799286435 cites W1860406582 @default.
• W2799286435 cites W1863942808 @default.
• W2799286435 cites W1901890356 @default.
• W2799286435 cites W1909995055 @default.
• W2799286435 cites W1916643957 @default.
• W2799286435 cites W1919390372 @default.
• W2799286435 cites W1964611857 @default.
• W2799286435 cites W1965269960 @default.
• W2799286435 cites W1966382356 @default.
• W2799286435 cites W1968408828 @default.
• W2799286435 cites W1968973107 @default.
• W2799286435 cites W1972784300 @default.
• W2799286435 cites W1975455559 @default.
• W2799286435 cites W1977673043 @default.
• W2799286435 cites W1985171602 @default.
• W2799286435 cites W1986435324 @default.
• W2799286435 cites W1986759659 @default.
• W2799286435 cites W1987942129 @default.
• W2799286435 cites W2003589153 @default.
• W2799286435 cites W2004067130 @default.
• W2799286435 cites W2018504160 @default.
• W2799286435 cites W2020254315 @default.
• W2799286435 cites W2022084096 @default.
• W2799286435 cites W2032233989 @default.
• W2799286435 cites W2033766684 @default.
• W2799286435 cites W2038521709 @default.
• W2799286435 cites W2039484989 @default.
• W2799286435 cites W2046448808 @default.
• W2799286435 cites W2056402592 @default.
• W2799286435 cites W2062890064 @default.
• W2799286435 cites W2063672950 @default.
• W2799286435 cites W2070842194 @default.
• W2799286435 cites W2086877453 @default.
• W2799286435 cites W2092626543 @default.
• W2799286435 cites W2099088452 @default.
• W2799286435 cites W2100197717 @default.
• W2799286435 cites W2103562758 @default.
• W2799286435 cites W2106730356 @default.
• W2799286435 cites W2107560422 @default.
• W2799286435 cites W2109169395 @default.
• W2799286435 cites W2111689540 @default.
• W2799286435 cites W2113589328 @default.
• W2799286435 cites W2114436437 @default.
• W2799286435 cites W2115519992 @default.
• W2799286435 cites W2116270192 @default.
• W2799286435 cites W2116458407 @default.
• W2799286435 cites W2117862272 @default.
• W2799286435 cites W2122669560 @default.
• W2799286435 cites W2126049681 @default.
• W2799286435 cites W2128161143 @default.
• W2799286435 cites W2128342567 @default.
• W2799286435 cites W2138512207 @default.
• W2799286435 cites W2141051651 @default.
• W2799286435 cites W2151579950 @default.
• W2799286435 cites W2153236387 @default.
• W2799286435 cites W2157843443 @default.
• W2799286435 cites W2163184659 @default.
• W2799286435 cites W2169715850 @default.
• W2799286435 cites W2170477120 @default.
• W2799286435 cites W2195424142 @default.
• W2799286435 cites W2219946511 @default.
• W2799286435 cites W2223501982 @default.
• W2799286435 cites W2229336932 @default.
• W2799286435 cites W2417667850 @default.
• W2799286435 cites W2417717334 @default.
• W2799286435 cites W2434767947 @default.
• W2799286435 cites W24684494 @default.
• W2799286435 cites W2479201778 @default.
• W2799286435 cites W2507590813 @default.
• W2799286435 cites W2523576980 @default.
• W2799286435 cites W2580440154 @default.
• W2799286435 cites W2735126316 @default.
• W2799286435 cites W2780849917 @default.
• W2799286435 cites W2789789909 @default.
• W2799286435 cites W2795596093 @default.
• W2799286435 cites W332402261 @default.
• W2799286435 cites W349844564 @default.
• W2799286435 cites W4246108565 @default.
• W2799286435 cites W56715191 @default.
• W2799286435 doi "https://doi.org/10.1186/s12931-018-0770-7" @default.
• W2799286435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5897944" @default.
• W2799286435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29650006" @default.
• W2799286435 hasPublicationYear "2018" @default.
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