FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799314805> ?p ?o ?g. }

• W2799314805 abstract "Abstract Microbes communicate with each other by using quorum sensing (QS) systems and modulate their collective ‘behavior’ for in-host colonization and virulence, biofilm formation, and environmental adaptation. The recent increase in genome data availability reveals the presence of several putative QS sensing circuits in microbial pathogens, but many of these have not been functionally characterized yet, despite their possible utility as drug targets. To increase the repertoire of functionally characterized QS systems in bacteria, we studied Rgg144/Shp144 and Rgg939/Shp939, two putative QS systems in the important human pathogen Streptococcus pneumoniae . We find that both of these QS circuits are induced by short hydrophobic peptides (Shp) upon sensing sugars found in the respiratory tract, such as galactose and mannose. Microarray analyses using cultures grown on mannose and galactose revealed that the expression of a large number of genes is controlled by these QS systems, especially those encoding for essential physiological functions and virulence-related genes such as the capsular locus. Moreover, the array data revealed evidence for cross-talk between these systems. Finally, these Rgg systems play a key role in colonization and virulence, as deletion mutants of these QS systems are attenuated in the mouse models of colonization and pneumonia." @default.
• W2799314805 created "2018-05-17" @default.
• W2799314805 creator A5001078286 @default.
• W2799314805 creator A5013019060 @default.
• W2799314805 creator A5013115877 @default.
• W2799314805 creator A5017690933 @default.
• W2799314805 creator A5017781414 @default.
• W2799314805 creator A5026322603 @default.
• W2799314805 creator A5047039315 @default.
• W2799314805 creator A5084308152 @default.
• W2799314805 creator A5089104394 @default.
• W2799314805 date "2018-04-23" @default.
• W2799314805 modified "2023-10-14" @default.
• W2799314805 title "Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis" @default.
• W2799314805 cites W1638080479 @default.
• W2799314805 cites W1862273946 @default.
• W2799314805 cites W1871472387 @default.
• W2799314805 cites W1966751635 @default.
• W2799314805 cites W1971470136 @default.
• W2799314805 cites W2002459863 @default.
• W2799314805 cites W2010428513 @default.
• W2799314805 cites W2024642613 @default.
• W2799314805 cites W2029069567 @default.
• W2799314805 cites W2031120873 @default.
• W2799314805 cites W2049329516 @default.
• W2799314805 cites W2053891677 @default.
• W2799314805 cites W2082093843 @default.
• W2799314805 cites W2088681575 @default.
• W2799314805 cites W2100379394 @default.
• W2799314805 cites W2100977464 @default.
• W2799314805 cites W2102107256 @default.
• W2799314805 cites W2102320362 @default.
• W2799314805 cites W2104762874 @default.
• W2799314805 cites W2105349726 @default.
• W2799314805 cites W2106979097 @default.
• W2799314805 cites W2108861643 @default.
• W2799314805 cites W2111619978 @default.
• W2799314805 cites W2112354069 @default.
• W2799314805 cites W2115859783 @default.
• W2799314805 cites W2119011504 @default.
• W2799314805 cites W2119358985 @default.
• W2799314805 cites W2127347791 @default.
• W2799314805 cites W2130492588 @default.
• W2799314805 cites W2132868585 @default.
• W2799314805 cites W2137032906 @default.
• W2799314805 cites W2140405224 @default.
• W2799314805 cites W2141735861 @default.
• W2799314805 cites W2142428670 @default.
• W2799314805 cites W2143502457 @default.
• W2799314805 cites W2145435157 @default.
• W2799314805 cites W2146559520 @default.
• W2799314805 cites W2149103948 @default.
• W2799314805 cites W2149117619 @default.
• W2799314805 cites W2151718652 @default.
• W2799314805 cites W2153544371 @default.
• W2799314805 cites W2154519103 @default.
• W2799314805 cites W2158626920 @default.
• W2799314805 cites W2165698978 @default.
• W2799314805 cites W2166666507 @default.
• W2799314805 cites W2167993491 @default.
• W2799314805 cites W2408351055 @default.
• W2799314805 cites W2413666049 @default.
• W2799314805 cites W2569540328 @default.
• W2799314805 cites W2591782305 @default.
• W2799314805 cites W2591998214 @default.
• W2799314805 cites W2614563414 @default.
• W2799314805 cites W2617286063 @default.
• W2799314805 cites W2618154477 @default.
• W2799314805 cites W2756033011 @default.
• W2799314805 cites W2766565841 @default.
• W2799314805 doi "https://doi.org/10.1038/s41598-018-24910-1" @default.
• W2799314805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5913232" @default.
• W2799314805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29686372" @default.
• W2799314805 hasPublicationYear "2018" @default.
• W2799314805 type Work @default.
• W2799314805 sameAs 2799314805 @default.
• W2799314805 citedByCount "25" @default.
• W2799314805 countsByYear W27993148052019 @default.
• W2799314805 countsByYear W27993148052020 @default.
• W2799314805 countsByYear W27993148052021 @default.
• W2799314805 countsByYear W27993148052022 @default.
• W2799314805 countsByYear W27993148052023 @default.
• W2799314805 crossrefType "journal-article" @default.
• W2799314805 hasAuthorship W2799314805A5001078286 @default.
• W2799314805 hasAuthorship W2799314805A5013019060 @default.
• W2799314805 hasAuthorship W2799314805A5013115877 @default.
• W2799314805 hasAuthorship W2799314805A5017690933 @default.
• W2799314805 hasAuthorship W2799314805A5017781414 @default.
• W2799314805 hasAuthorship W2799314805A5026322603 @default.
• W2799314805 hasAuthorship W2799314805A5047039315 @default.
• W2799314805 hasAuthorship W2799314805A5084308152 @default.
• W2799314805 hasAuthorship W2799314805A5089104394 @default.
• W2799314805 hasBestOaLocation W27993148051 @default.
• W2799314805 hasConcept C104317684 @default.
• W2799314805 hasConcept C118687296 @default.
• W2799314805 hasConcept C143065580 @default.
• W2799314805 hasConcept C179470777 @default.
• W2799314805 hasConcept C2775887612 @default.
• W2799314805 hasConcept C2776927270 @default.
• W2799314805 hasConcept C2781253189 @default.

• next