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- W2799330168 abstract "Abstract Excessive reactive oxygen species (ROS) are crucial intermediaries in promoting degenerative states in tissues. Oxidative damage caused by excessive ROS elicits cellular apoptotic pathways. Despite extensive studies exploring oxidative stress mechanisms, little is known about the contribution of ROS to the pathogenesis of tissue degeneration. Here, the development of an engineered nanoreactor that scavenges ROS in a dose‐dependent fashion is reported for the first time. It is demonstrated that the protective effect of the engineered MnO 2 nanoreactors developed by incorporating MnO 2 nanoparticles within a collagen matrix eliminated the inherent toxicity of MnO 2 nanoparticles and enhanced their efficacy to attenuate oxidative stress. In addition, the direct reactivity of MnO 2 toward peroxides and the nanoreactors' efficacy to regulate oxidative stress and modulate inflammation in tissues are demonstrated. As a proof of concept, the attenuation of excessive ROS production in a validated ex vivo organotypic intervertebral disc model of inflammation is assessed. The results demonstrate that the unique environment of the MnO 2 nanoreactor results in the inhibition of ROS‐induced apoptosis, regulation of oxidative stress, modulation of inflammation in tissues, and reduction of cell apoptosis without impairing cellular proliferation. Thus, this resulting platform technology has applications in a broad range of inflammatory diseases." @default.
- W2799330168 created "2018-05-17" @default.
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- W2799330168 date "2018-05-10" @default.
- W2799330168 modified "2023-10-14" @default.
- W2799330168 title "Scavenging Nanoreactors that Modulate Inflammation" @default.
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- W2799330168 cites W1977981631 @default.
- W2799330168 cites W1978653530 @default.
- W2799330168 cites W1987872284 @default.
- W2799330168 cites W1990057346 @default.
- W2799330168 cites W1992313984 @default.
- W2799330168 cites W1992471993 @default.
- W2799330168 cites W1993505142 @default.
- W2799330168 cites W1995650257 @default.
- W2799330168 cites W2006525645 @default.
- W2799330168 cites W2007590483 @default.
- W2799330168 cites W2019450369 @default.
- W2799330168 cites W2024387421 @default.
- W2799330168 cites W2026776474 @default.
- W2799330168 cites W2037498968 @default.
- W2799330168 cites W2038636572 @default.
- W2799330168 cites W2039653102 @default.
- W2799330168 cites W2042108544 @default.
- W2799330168 cites W2042131412 @default.
- W2799330168 cites W2046634887 @default.
- W2799330168 cites W2048104669 @default.
- W2799330168 cites W2049880533 @default.
- W2799330168 cites W2052355479 @default.
- W2799330168 cites W2052501258 @default.
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- W2799330168 cites W2055631141 @default.
- W2799330168 cites W2056168344 @default.
- W2799330168 cites W2060207204 @default.
- W2799330168 cites W2061156116 @default.
- W2799330168 cites W2063304359 @default.
- W2799330168 cites W2066931502 @default.
- W2799330168 cites W2069813820 @default.
- W2799330168 cites W2073804467 @default.
- W2799330168 cites W2075216923 @default.
- W2799330168 cites W2076098443 @default.
- W2799330168 cites W2084066569 @default.
- W2799330168 cites W2084141237 @default.
- W2799330168 cites W2090822721 @default.
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- W2799330168 cites W2092798278 @default.
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- W2799330168 cites W2103791313 @default.
- W2799330168 cites W2113651620 @default.
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- W2799330168 cites W2131802101 @default.
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- W2799330168 cites W2154884921 @default.
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- W2799330168 cites W2178938680 @default.
- W2799330168 cites W2281598305 @default.
- W2799330168 cites W2350256796 @default.
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- W2799330168 doi "https://doi.org/10.1002/adbi.201800086" @default.
- W2799330168 hasPublicationYear "2018" @default.
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