FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799339544> ?p ?o ?g. }

• W2799339544 endingPage "1139" @default.
• W2799339544 startingPage "1127" @default.
• W2799339544 abstract "Age-related macular degeneration (AMD) is the main reason for blindness in elderly people in the developed countries. Current screening protocols have limitations in detecting the early signs of retinal degeneration. Therefore, it would be desirable to find novel biomarkers for early detection of AMD. Development of novel biomarkers would help in the prevention, diagnostics, and treatment of AMD. Proteomic analysis of tear film has shown promise in this research area. If an optimal set of biomarkers could be obtained from accessible body fluids, it would represent a reliable way to monitor disease progression and response to novel therapies.Tear films were collected on Schirmer strips from a total of 22 patients (8 with wet AMD, 6 with dry AMD, and 8 control individuals). 2D electrophoresis was used to separate tear film proteins prior to their identification with matrix-assisted laser desorption/ionization time of flight spectrometer (MALDI-TOF/TOF) and matching with functional databases.A total of 342 proteins were identified. Most of them were previously described in various proteomic studies concerning AMD. Shootin-1, histatin-3, fidgetin-like protein 1, SRC kinase signaling inhibitor, Graves disease carrier protein, actin cytoplasmic 1, prolactin-inducible protein 1, and protein S100-A7A were upregulated in the tear film samples isolated from AMD patients and were not previously linked with this disease in any proteomic analysis.The upregulated proteins supplement our current knowledge of AMD pathogenesis, providing evidence that certain specific proteins are expressed into the tear film in AMD. As far we are aware, this is the first study to have undertaken a comprehensive in-depth analysis of the human tear film proteome in AMD patients." @default.
• W2799339544 created "2018-05-17" @default.
• W2799339544 creator A5021448617 @default.
• W2799339544 creator A5031481747 @default.
• W2799339544 creator A5050454426 @default.
• W2799339544 creator A5052820197 @default.
• W2799339544 creator A5059206058 @default.
• W2799339544 creator A5071149911 @default.
• W2799339544 date "2018-04-25" @default.
• W2799339544 modified "2023-10-12" @default.
• W2799339544 title "Tear film proteome in age-related macular degeneration" @default.
• W2799339544 cites W101661586 @default.
• W2799339544 cites W123772418 @default.
• W2799339544 cites W138949821 @default.
• W2799339544 cites W1523693806 @default.
• W2799339544 cites W1530827369 @default.
• W2799339544 cites W1538482378 @default.
• W2799339544 cites W1548614387 @default.
• W2799339544 cites W1553154837 @default.
• W2799339544 cites W1608734297 @default.
• W2799339544 cites W1775759920 @default.
• W2799339544 cites W1807341246 @default.
• W2799339544 cites W1813213480 @default.
• W2799339544 cites W1844680931 @default.
• W2799339544 cites W1961098424 @default.
• W2799339544 cites W1967234985 @default.
• W2799339544 cites W1975188427 @default.
• W2799339544 cites W1976267352 @default.
• W2799339544 cites W2000830616 @default.
• W2799339544 cites W2002671131 @default.
• W2799339544 cites W2005487633 @default.
• W2799339544 cites W2013800293 @default.
• W2799339544 cites W2021234912 @default.
• W2799339544 cites W2023897774 @default.
• W2799339544 cites W2024762488 @default.
• W2799339544 cites W2025645303 @default.
• W2799339544 cites W2028544780 @default.
• W2799339544 cites W2032217161 @default.
• W2799339544 cites W2032679742 @default.
• W2799339544 cites W2033625993 @default.
• W2799339544 cites W2033664528 @default.
• W2799339544 cites W2034041091 @default.
• W2799339544 cites W2039676145 @default.
• W2799339544 cites W2044227662 @default.
• W2799339544 cites W2044488811 @default.
• W2799339544 cites W2046016011 @default.
• W2799339544 cites W2049355685 @default.
• W2799339544 cites W2067909356 @default.
• W2799339544 cites W2078594804 @default.
• W2799339544 cites W2081313626 @default.
• W2799339544 cites W2081341046 @default.
• W2799339544 cites W2082402714 @default.
• W2799339544 cites W2092440615 @default.
• W2799339544 cites W2092622551 @default.
• W2799339544 cites W2092996093 @default.
• W2799339544 cites W2097382830 @default.
• W2799339544 cites W2099082104 @default.
• W2799339544 cites W2113761013 @default.
• W2799339544 cites W2113775510 @default.
• W2799339544 cites W2119187102 @default.
• W2799339544 cites W2125232760 @default.
• W2799339544 cites W2136501493 @default.
• W2799339544 cites W2139820020 @default.
• W2799339544 cites W2150414697 @default.
• W2799339544 cites W2172287880 @default.
• W2799339544 cites W2200075236 @default.
• W2799339544 cites W2228321889 @default.
• W2799339544 cites W2264982258 @default.
• W2799339544 cites W2317534840 @default.
• W2799339544 cites W2319574713 @default.
• W2799339544 cites W2331355337 @default.
• W2799339544 cites W2337402992 @default.
• W2799339544 cites W2347205644 @default.
• W2799339544 cites W2461853521 @default.
• W2799339544 cites W2507428093 @default.
• W2799339544 cites W2517700939 @default.
• W2799339544 cites W2558766938 @default.
• W2799339544 cites W2559175446 @default.
• W2799339544 cites W2587946214 @default.
• W2799339544 cites W2601396686 @default.
• W2799339544 cites W2647725203 @default.
• W2799339544 cites W2739820486 @default.
• W2799339544 cites W2740579901 @default.
• W2799339544 cites W2752326209 @default.
• W2799339544 doi "https://doi.org/10.1007/s00417-018-3984-y" @default.
• W2799339544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5956098" @default.
• W2799339544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29696386" @default.
• W2799339544 hasPublicationYear "2018" @default.
• W2799339544 type Work @default.
• W2799339544 sameAs 2799339544 @default.
• W2799339544 citedByCount "28" @default.
• W2799339544 countsByYear W27993395442018 @default.
• W2799339544 countsByYear W27993395442019 @default.
• W2799339544 countsByYear W27993395442020 @default.
• W2799339544 countsByYear W27993395442021 @default.
• W2799339544 countsByYear W27993395442022 @default.
• W2799339544 countsByYear W27993395442023 @default.
• W2799339544 crossrefType "journal-article" @default.

• next