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- W2799343430 abstract "Despite extensive efforts in recent years, the blood-brain barrier (BBB) remains a significant obstacle for drug delivery. This study proposes using a clinical extracorporeal shockwave instrument to open the BBB, combined with a laser assisted bi-axial locating platform to achieve non-invasive, controllable-focus and reversible BBB opening in the brains of rats. Under shockwave treatment with an intensity level of 5 (P-9.79 MPa, energy flux density (EFD) 0.21 mJ/mm2) and a pulse repetition frequency of 5 Hz, the BBB could be opened after 50 shocks without the use of an ultrasound contrast agent. With the proposed method, the BBB opening can be precisely controlled in terms of depth, size and location. Moreover, a shockwave based gene transfection was demonstrated using a luciferase gene." @default.
- W2799343430 created "2018-05-17" @default.
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- W2799343430 date "2018-02-02" @default.
- W2799343430 modified "2023-10-15" @default.
- W2799343430 title "Focused shockwave induced blood-brain barrier opening and transfection" @default.
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- W2799343430 doi "https://doi.org/10.1038/s41598-018-20672-y" @default.
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