Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799343886> ?p ?o ?g. }
- W2799343886 abstract "Abstract Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits. However, why new clustered spines occur in specific locations and how their formation relates to learning and memory (L&M) remain unclear. Using in vivo two-photon microscopy, we track spine dynamics in retrosplenial cortex before, during, and after two forms of episodic-like learning and find that spine turnover before learning predicts future L&M performance, as well as the localization and rates of spine clustering. Consistent with the idea that these measures are causally related, a genetic manipulation that enhances spine turnover also enhances both L&M and spine clustering. Biophysically inspired modeling suggests turnover increases clustering, network sparsity, and memory capacity. These results support a hotspot model where spine turnover is the driver for localization of clustered spine formation, which serves to modulate network function, thus influencing storage capacity and L&M." @default.
- W2799343886 created "2018-05-17" @default.
- W2799343886 creator A5003333805 @default.
- W2799343886 creator A5016283139 @default.
- W2799343886 creator A5027807679 @default.
- W2799343886 creator A5028922455 @default.
- W2799343886 creator A5061267714 @default.
- W2799343886 creator A5072368304 @default.
- W2799343886 creator A5080156472 @default.
- W2799343886 creator A5080616257 @default.
- W2799343886 creator A5084437054 @default.
- W2799343886 creator A5088598187 @default.
- W2799343886 creator A5088985344 @default.
- W2799343886 date "2018-01-29" @default.
- W2799343886 modified "2023-10-16" @default.
- W2799343886 title "Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory" @default.
- W2799343886 cites W1440335865 @default.
- W2799343886 cites W1642243794 @default.
- W2799343886 cites W1966155655 @default.
- W2799343886 cites W1976485053 @default.
- W2799343886 cites W1979019425 @default.
- W2799343886 cites W1980452424 @default.
- W2799343886 cites W1985450720 @default.
- W2799343886 cites W1990107671 @default.
- W2799343886 cites W1990561503 @default.
- W2799343886 cites W1991490575 @default.
- W2799343886 cites W1995001752 @default.
- W2799343886 cites W1997375364 @default.
- W2799343886 cites W2001528712 @default.
- W2799343886 cites W2003766648 @default.
- W2799343886 cites W2009360478 @default.
- W2799343886 cites W2011882079 @default.
- W2799343886 cites W2012010559 @default.
- W2799343886 cites W2012985621 @default.
- W2799343886 cites W2019251983 @default.
- W2799343886 cites W2019523818 @default.
- W2799343886 cites W2022698353 @default.
- W2799343886 cites W2031313254 @default.
- W2799343886 cites W2032123764 @default.
- W2799343886 cites W2033382579 @default.
- W2799343886 cites W2041864194 @default.
- W2799343886 cites W2048129186 @default.
- W2799343886 cites W2052426068 @default.
- W2799343886 cites W2055854037 @default.
- W2799343886 cites W2059288735 @default.
- W2799343886 cites W2067868188 @default.
- W2799343886 cites W2072949646 @default.
- W2799343886 cites W2073564837 @default.
- W2799343886 cites W2084889756 @default.
- W2799343886 cites W2086841290 @default.
- W2799343886 cites W2088446997 @default.
- W2799343886 cites W2088475496 @default.
- W2799343886 cites W2092348167 @default.
- W2799343886 cites W2093335984 @default.
- W2799343886 cites W2094455233 @default.
- W2799343886 cites W2095058920 @default.
- W2799343886 cites W2099347739 @default.
- W2799343886 cites W2104742248 @default.
- W2799343886 cites W2107633128 @default.
- W2799343886 cites W2108373345 @default.
- W2799343886 cites W2110016065 @default.
- W2799343886 cites W2112075984 @default.
- W2799343886 cites W2118069376 @default.
- W2799343886 cites W2122682406 @default.
- W2799343886 cites W2138144699 @default.
- W2799343886 cites W2139053813 @default.
- W2799343886 cites W2146655366 @default.
- W2799343886 cites W2147033427 @default.
- W2799343886 cites W2162407586 @default.
- W2799343886 cites W2163006398 @default.
- W2799343886 cites W2164649534 @default.
- W2799343886 cites W2176569267 @default.
- W2799343886 cites W2407862866 @default.
- W2799343886 cites W2423540713 @default.
- W2799343886 cites W2514163892 @default.
- W2799343886 cites W2537787732 @default.
- W2799343886 cites W2548724400 @default.
- W2799343886 cites W2561607968 @default.
- W2799343886 cites W2734679532 @default.
- W2799343886 cites W4210779824 @default.
- W2799343886 cites W4211021876 @default.
- W2799343886 cites W4254720894 @default.
- W2799343886 doi "https://doi.org/10.1038/s41467-017-02751-2" @default.
- W2799343886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5789055" @default.
- W2799343886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29379017" @default.
- W2799343886 hasPublicationYear "2018" @default.
- W2799343886 type Work @default.
- W2799343886 sameAs 2799343886 @default.
- W2799343886 citedByCount "114" @default.
- W2799343886 countsByYear W27993438862018 @default.
- W2799343886 countsByYear W27993438862019 @default.
- W2799343886 countsByYear W27993438862020 @default.
- W2799343886 countsByYear W27993438862021 @default.
- W2799343886 countsByYear W27993438862022 @default.
- W2799343886 countsByYear W27993438862023 @default.
- W2799343886 crossrefType "journal-article" @default.
- W2799343886 hasAuthorship W2799343886A5003333805 @default.
- W2799343886 hasAuthorship W2799343886A5016283139 @default.
- W2799343886 hasAuthorship W2799343886A5027807679 @default.
- W2799343886 hasAuthorship W2799343886A5028922455 @default.