FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799367481> ?p ?o ?g. }

• W2799367481 endingPage "1194" @default.
• W2799367481 startingPage "1188" @default.
• W2799367481 abstract "The dimerization and high-order oligomerization of transcription factors has endowed them with cooperative regulatory capabilities that play important roles in many cellular functions. However, such advanced regulatory capabilities have not been fully exploited in synthetic biology and genetic engineering. Here, we engineered a C-terminally fused oligomerization domain to improve the cooperativity of transcription factors. First, we found that two of three designed oligomerization domains significantly increased the cooperativity and ultrasensitivity of a transcription factor for the regulated promoter. Then, seven additional transcription factors were used to assess the modularity of the oligomerization domains, and their ultrasensitivity was generally improved, as assessed by their Hill coefficients. Moreover, we also demonstrated that the allosteric capability of the ligand-responsive domain remained intact when fusing with the designed oligomerization domain. As an example application, we showed that the engineered ultrasensitive transcription factor could be used to significantly improve the performance of a “stripe-forming” gene circuit. We envision that the oligomerization modules engineered in this study could act as a powerful tool to rapidly tune the underlying response profiles of synthetic gene circuits and metabolic pathway controllers." @default.
• W2799367481 created "2018-05-17" @default.
• W2799367481 creator A5037935576 @default.
• W2799367481 creator A5038563026 @default.
• W2799367481 creator A5043534567 @default.
• W2799367481 creator A5053114263 @default.
• W2799367481 creator A5054126201 @default.
• W2799367481 creator A5058388163 @default.
• W2799367481 creator A5063932378 @default.
• W2799367481 date "2018-05-07" @default.
• W2799367481 modified "2023-10-10" @default.
• W2799367481 title "Engineering the Ultrasensitive Transcription Factors by Fusing a Modular Oligomerization Domain" @default.
• W2799367481 cites W1213974439 @default.
• W2799367481 cites W1835542029 @default.
• W2799367481 cites W1974895088 @default.
• W2799367481 cites W1991793399 @default.
• W2799367481 cites W1992210744 @default.
• W2799367481 cites W1995359902 @default.
• W2799367481 cites W1997566863 @default.
• W2799367481 cites W2009204231 @default.
• W2799367481 cites W2020044960 @default.
• W2799367481 cites W2021059161 @default.
• W2799367481 cites W2022034040 @default.
• W2799367481 cites W2026644028 @default.
• W2799367481 cites W2027576577 @default.
• W2799367481 cites W2038592503 @default.
• W2799367481 cites W2039309132 @default.
• W2799367481 cites W2045088907 @default.
• W2799367481 cites W2045475749 @default.
• W2799367481 cites W2063613623 @default.
• W2799367481 cites W2073588416 @default.
• W2799367481 cites W2082929826 @default.
• W2799367481 cites W2084276913 @default.
• W2799367481 cites W2090609904 @default.
• W2799367481 cites W2099183748 @default.
• W2799367481 cites W2102334149 @default.
• W2799367481 cites W2102964870 @default.
• W2799367481 cites W2105993993 @default.
• W2799367481 cites W2111869546 @default.
• W2799367481 cites W2134174762 @default.
• W2799367481 cites W2134668325 @default.
• W2799367481 cites W2135515319 @default.
• W2799367481 cites W2143984892 @default.
• W2799367481 cites W2149778176 @default.
• W2799367481 cites W2159882496 @default.
• W2799367481 cites W2164424555 @default.
• W2799367481 cites W2168275195 @default.
• W2799367481 cites W2237647745 @default.
• W2799367481 cites W2260617737 @default.
• W2799367481 cites W2332777352 @default.
• W2799367481 cites W2479475554 @default.
• W2799367481 cites W2541610028 @default.
• W2799367481 cites W2673967722 @default.
• W2799367481 doi "https://doi.org/10.1021/acssynbio.7b00414" @default.
• W2799367481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29733626" @default.
• W2799367481 hasPublicationYear "2018" @default.
• W2799367481 type Work @default.
• W2799367481 sameAs 2799367481 @default.
• W2799367481 citedByCount "17" @default.
• W2799367481 countsByYear W27993674812018 @default.
• W2799367481 countsByYear W27993674812019 @default.
• W2799367481 countsByYear W27993674812020 @default.
• W2799367481 countsByYear W27993674812021 @default.
• W2799367481 countsByYear W27993674812022 @default.
• W2799367481 countsByYear W27993674812023 @default.
• W2799367481 crossrefType "journal-article" @default.
• W2799367481 hasAuthorship W2799367481A5037935576 @default.
• W2799367481 hasAuthorship W2799367481A5038563026 @default.
• W2799367481 hasAuthorship W2799367481A5043534567 @default.
• W2799367481 hasAuthorship W2799367481A5053114263 @default.
• W2799367481 hasAuthorship W2799367481A5054126201 @default.
• W2799367481 hasAuthorship W2799367481A5058388163 @default.
• W2799367481 hasAuthorship W2799367481A5063932378 @default.
• W2799367481 hasBestOaLocation W27993674812 @default.
• W2799367481 hasConcept C101468663 @default.
• W2799367481 hasConcept C104317684 @default.
• W2799367481 hasConcept C107824862 @default.
• W2799367481 hasConcept C111919701 @default.
• W2799367481 hasConcept C111936080 @default.
• W2799367481 hasConcept C138885662 @default.
• W2799367481 hasConcept C147816474 @default.
• W2799367481 hasConcept C150194340 @default.
• W2799367481 hasConcept C166014724 @default.
• W2799367481 hasConcept C166342909 @default.
• W2799367481 hasConcept C170493617 @default.
• W2799367481 hasConcept C178790620 @default.
• W2799367481 hasConcept C179926584 @default.
• W2799367481 hasConcept C181199279 @default.
• W2799367481 hasConcept C185592680 @default.
• W2799367481 hasConcept C187250156 @default.
• W2799367481 hasConcept C190796033 @default.
• W2799367481 hasConcept C191908910 @default.
• W2799367481 hasConcept C2779478453 @default.
• W2799367481 hasConcept C41008148 @default.
• W2799367481 hasConcept C41895202 @default.
• W2799367481 hasConcept C54355233 @default.
• W2799367481 hasConcept C55493867 @default.
• W2799367481 hasConcept C65604355 @default.

• next