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• W2799387528 abstract "Photoreceptor cell death in inherited retinal degeneration is accompanied by over-activation of histone deacetylases (HDAC). Excessive HDAC activity is found both in primary rod degeneration (such as in the rd10 mouse) and in primary cone death, including the cone photoreceptor function loss 1 (cpfl1) mouse. We evaluated the potential of pharmacological HDAC inhibition to prevent photoreceptor degeneration in primary rod and cone degeneration. We show that a single in vivo treatment of cpfl1 mice with the HDAC inhibitor trichostatin A (TSA) resulted in a significant protection of cpfl1 mutant cones. Similarly, HDAC inhibition with the clinically approved HDAC inhibitor vorinostat (SAHA) resulted in a significant improvement of rod survival in rd10 retinal explant cultures. Altogether, these results highlight the feasibility of targeted neuroprotection in vivo and create hope to maintain vision in patients suffering from both rod and cone dystrophies." @default.
• W2799387528 created "2018-05-17" @default.
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• W2799387528 date "2018-01-01" @default.
• W2799387528 modified "2023-10-16" @default.
• W2799387528 title "Primary Rod and Cone Degeneration Is Prevented by HDAC Inhibition" @default.
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• W2799387528 doi "https://doi.org/10.1007/978-3-319-75402-4_45" @default.
• W2799387528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29721965" @default.
• W2799387528 hasPublicationYear "2018" @default.
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