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- W2799391188 abstract "North Borneo, located in the Coral Triangle Region (CTR), the world's marine megabiodiversity, has an extremely rich source of marine life. The marine ecosystem is afusion of complex interaction between the marine environment and marineorganisms leading to predatory, competition for space or habitat, protection fromdisease or infection and directly imposing the pressure to survive among slowmoving,sessile soft bodied marine invertebrates. Thus, marine invertebratesbiosynthesize secondary metabolites as a means ,of self defence. Recentdevelopment in drug discovery has revealed the potential of marine secondarymetabolites as lead pharmaceutical drugs. This research focuses on twoinvertebrates; the sea hare Aplysia dactylomela Rang and Alcyonacean soft corals(Lobophytum pauciflorum, Sinularia flexibilis and Scleronephthea corymbosa) toinvestigate the structural diversity of secondary metabolites and its biologicalpotentials. Populations of A. dactylomela from Dinawan Island yielded 10compounds, Sulug Island yielded 9 compounds and Mantanani Island yielded 12compounds, comprising of five new compounds with two new chemical skeletons.Compounds were mostly halogenated and comprised of acetogenins, charmigrane,cuparane, syndrean and bromoindoles. Three Alcyonacean soft coral species wereanalysed to contain 22 secondary metabolites; Lobophytum pauciflorum yielded 6compounds, Scleronephthya corymbosa yielded 6 compounds and Sinularia flexibilisyielded 10 compounds comprising of furanocembranoids, pregnane type strerols andcembrane diterpenes. Secondary metabolites from the soft corals yielded five newcompounds. Structure eluddation of compounds was determined via 10-NMR(proton and carbon), 2D-NMR (HSQC, COSY, HMBC and NOESY), HRMS and FTlRmeasurements. Sesquiterpenes (+)-elatol (16) and 2,3,5,6-tetrabromoindole (22)inhibited the growth of Escherichia coli (HP0408) and Vibrio cholera (HP0908) at MIC5 µg/mL and 10 µg/mL. The syndrean 12-acetoxypalisadin B (0.02 %)(13) andpregnane sterol P3N-4 (0.01 %) (32) displayed cytotoxicity towards HL60 (13µg/mL) and B16FI0 (17 µg/mL) cancer cell line respectively while thefuranocembranoid SCl-8 (0.01 %) (28) best suppressed inflammation in LPSinduced RAW 264.7 cell and zebra fish embryo at 10 µg/ml concentration. As such,the adaptation of marine invertebrate in the marine environment caters to greatpotential as an important source of lead pharmaceutical metabolites." @default.
- W2799391188 created "2018-05-17" @default.
- W2799391188 creator A5045367683 @default.
- W2799391188 date "2015-01-01" @default.
- W2799391188 modified "2023-09-23" @default.
- W2799391188 title "Structural diversity and biological properties of secondary metabolites from sea hare (Aplysia dacdtylomela) and Alcyonacean soft corals" @default.
- W2799391188 hasPublicationYear "2015" @default.
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