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• W2799393923 abstract "Background Isocapnic hyperventilation ( IHV ) shortens recovery time after inhalation anaesthesia by increasing ventilation while maintaining a normal airway carbon dioxide ( CO 2 )‐level. One way of performing IHV is to infuse CO 2 to the inspiratory limb of a breathing circuit during mechanical hyperventilation ( HV ). In a prospective randomized study, we compared this IHV technique to a standard emergence procedure (control). Methods Thirty‐one adult ASA I‐ III patients undergoing long‐duration (>3 hours) sevoflurane anaesthesia for major head and neck surgery were included and randomized to IHV ‐treatment (n = 16) or control (n = 15). IHV was performed at minute ventilation 13.6 ± 4.3 L/min and CO 2 delivery, dosed according to a nomogram tested in a pilot study. Time to extubation and eye‐opening was recorded. Inspired ( FICO 2 ) and expired ( FETCO 2 ) CO 2 and arterial CO 2 levels (Pa CO 2 ) were monitored. Cognition was tested preoperatively and at 20, 40 and 60 minutes after surgery. Results Time from turning off the vapourizer to extubation was 13.7 ± 2.5 minutes in the IHV group and 27.4 ± 6.5 minutes in controls ( P < .001). Two minutes after extubation, Pa CO 2 was 6.2 ± 0.5 and 6.2 ± 0.6 kP a in the IHV and control group respectively. In 69% ( IHV ) vs 53% (controls), post‐operative cognition returned to pre‐operative values within 40 minutes after surgery ( NS ). Incidences of pain and nausea/vomiting did not differ between groups. Conclusions In this randomized trial comparing an IHV method with a standard weaning procedure, time to extubation was reduced with 50% in the IHV group. The described IHV method can be used to decrease emergence time from inhalation anaesthesia." @default.
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• W2799393923 date "2018-04-19" @default.
• W2799393923 modified "2023-09-26" @default.
• W2799393923 title "Isocapnic hyperventilation provides early extubation after head and neck surgery: A prospective randomized trial" @default.
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• W2799393923 doi "https://doi.org/10.1111/aas.13133" @default.
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