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- W2799395388 abstract "Moonlighting proteins exhibit multiple activities in different cellular compartments, and their abnormal regulation could play an important role in many diseases. To date, many proteins have been identified with moonlighting activity, and more such proteins are being gradually identified. Among the proteins that possess moonlighting activity, several secreted proteins exhibit multiple activities in different cellular locations, such as the extracellular matrix, nucleus, and cytoplasm. While acute inflammation starts rapidly and generally disappears in a few days, chronic inflammation can last for months or years. This is generally because of the failure to eliminate the cause of inflammation, along with repeated exposure to the inflammatory agent. Chronic inflammation is now considered as an overwhelming burden to the general wellbeing of patients and noted as an underlying cause of several diseases. Moonlighting proteins can contribute to the process of chronic inflammation; therefore, it is imperative to overview some proteins that exhibit multiple functions in inflammatory diseases. In this review, we will focus on inflammation, particularly unravelling several well-known secreted proteins with multiple functions in different cellular locations." @default.
- W2799395388 created "2018-05-17" @default.
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- W2799395388 date "2018-01-01" @default.
- W2799395388 modified "2023-10-15" @default.
- W2799395388 title "Moonlighting Activity of Secreted Inflammation-Regulatory Proteins" @default.
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- W2799395388 doi "https://doi.org/10.3349/ymj.2018.59.4.463" @default.
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