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- W2799398987 abstract "Abstract Comprehensive understanding of signaling pathways regulating cancer progression has led to tremendous advances of molecularly targeted therapies. The epidermal growth factor receptor (EGFR) pathway is an attractive target for cancer therapy, and targeting multiple key elements in the pathway may further facilitate therapeutic efficacy. Here, an EGFR‐targeted nanoprodrug is demonstrated for in vivo imaging and tumor inhibition, which is assembled by a disulfide‐bridged quercetin (QSSQ) and an EGFR inhibitor erlotinib. QSSQ is synthesized via chemical manipulation of multiple phenolic hydroxyl groups on quercetin; and the nanoprodrug is then fabricated through the disulfide‐facilitated assembly of QSSQ and erlotinib. The nanoprodrug is of high drug loading (87.3%) since its only inert component is the disulfide linker. The nanoprodrug is stable in physiological environment, whereas overexpressed glutathione in tumor tissue breaks the disulfide bridge, thereby disrupting the nanostructure and releasing active drugs quercetin and erlotinib. Upon release, erlotinib serves as an active drug blocking the EGFR tyrosine kinase, and quercetin generates strong aggregation‐induced emission of fluorescence for imaging drug release and acts as another drug inhibiting the downstream EFGR signaling, as evidenced by Western blotting analyses. The combined action thereof results in remarkable antitumor efficacy toward xenograft tumor‐bearing mice." @default.
- W2799398987 created "2018-05-17" @default.
- W2799398987 creator A5012069874 @default.
- W2799398987 creator A5029241233 @default.
- W2799398987 creator A5043883660 @default.
- W2799398987 creator A5048257624 @default.
- W2799398987 creator A5052907339 @default.
- W2799398987 creator A5066444907 @default.
- W2799398987 date "2018-04-18" @default.
- W2799398987 modified "2023-10-14" @default.
- W2799398987 title "Tumor Inhibition Achieved by Targeting and Regulating Multiple Key Elements in EGFR Signaling Pathway Using a Self-Assembled Nanoprodrug" @default.
- W2799398987 cites W1848342177 @default.
- W2799398987 cites W1964321121 @default.
- W2799398987 cites W1967394241 @default.
- W2799398987 cites W1971236478 @default.
- W2799398987 cites W1975996322 @default.
- W2799398987 cites W1987717478 @default.
- W2799398987 cites W1998700258 @default.
- W2799398987 cites W2006169733 @default.
- W2799398987 cites W2013524642 @default.
- W2799398987 cites W2024382973 @default.
- W2799398987 cites W2028415754 @default.
- W2799398987 cites W2029480581 @default.
- W2799398987 cites W2030133707 @default.
- W2799398987 cites W2033570341 @default.
- W2799398987 cites W2041716856 @default.
- W2799398987 cites W2042278676 @default.
- W2799398987 cites W2071274102 @default.
- W2799398987 cites W2077804275 @default.
- W2799398987 cites W2094992173 @default.
- W2799398987 cites W2100664846 @default.
- W2799398987 cites W2100912832 @default.
- W2799398987 cites W2101350424 @default.
- W2799398987 cites W2104271245 @default.
- W2799398987 cites W2104287359 @default.
- W2799398987 cites W2108843890 @default.
- W2799398987 cites W2109678955 @default.
- W2799398987 cites W2115607919 @default.
- W2799398987 cites W2124998946 @default.
- W2799398987 cites W2130166533 @default.
- W2799398987 cites W2134964659 @default.
- W2799398987 cites W2134989772 @default.
- W2799398987 cites W2138297714 @default.
- W2799398987 cites W2141260063 @default.
- W2799398987 cites W2148174696 @default.
- W2799398987 cites W2150735425 @default.
- W2799398987 cites W2155968160 @default.
- W2799398987 cites W2161682775 @default.
- W2799398987 cites W2165423570 @default.
- W2799398987 cites W2181028748 @default.
- W2799398987 cites W2184400966 @default.
- W2799398987 cites W2216368112 @default.
- W2799398987 cites W2218497166 @default.
- W2799398987 cites W2227937438 @default.
- W2799398987 cites W2235324276 @default.
- W2799398987 cites W2289158769 @default.
- W2799398987 cites W2289266827 @default.
- W2799398987 cites W2327890634 @default.
- W2799398987 cites W2343061763 @default.
- W2799398987 cites W2345067801 @default.
- W2799398987 cites W2378279697 @default.
- W2799398987 cites W2396740212 @default.
- W2799398987 cites W2401893904 @default.
- W2799398987 cites W2413291394 @default.
- W2799398987 cites W2464143334 @default.
- W2799398987 cites W2482902162 @default.
- W2799398987 cites W2503470809 @default.
- W2799398987 cites W2511157305 @default.
- W2799398987 cites W2513565515 @default.
- W2799398987 cites W2519809863 @default.
- W2799398987 cites W2528255417 @default.
- W2799398987 cites W2541058996 @default.
- W2799398987 cites W2542884666 @default.
- W2799398987 cites W2546440199 @default.
- W2799398987 cites W2553807524 @default.
- W2799398987 cites W2561216063 @default.
- W2799398987 cites W2566001100 @default.
- W2799398987 cites W2567319330 @default.
- W2799398987 cites W2568166803 @default.
- W2799398987 cites W2580488838 @default.
- W2799398987 cites W2586311061 @default.
- W2799398987 cites W2586486767 @default.
- W2799398987 cites W2586840087 @default.
- W2799398987 cites W2590680367 @default.
- W2799398987 cites W2593414082 @default.
- W2799398987 cites W2599622399 @default.
- W2799398987 cites W2604354601 @default.
- W2799398987 cites W2606462493 @default.
- W2799398987 cites W2610750168 @default.
- W2799398987 cites W2611571183 @default.
- W2799398987 cites W2612675743 @default.
- W2799398987 cites W2613285818 @default.
- W2799398987 cites W2616974369 @default.
- W2799398987 cites W2657126980 @default.
- W2799398987 cites W2735293540 @default.
- W2799398987 cites W2739901926 @default.
- W2799398987 cites W2742611741 @default.
- W2799398987 cites W2744807275 @default.
- W2799398987 cites W2747169234 @default.
- W2799398987 cites W2750726335 @default.