Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799402272> ?p ?o ?g. }
- W2799402272 endingPage "14" @default.
- W2799402272 startingPage "1" @default.
- W2799402272 abstract "Caerin is a family of peptides isolated from the glandular secretion of Australian tree frogs, the genus Litoria, and has been previously shown to have anticancer activity against several cancer cells. In this work, we used two host-defence peptides, caerin 1.1 and caerin 1.9, to investigate their ability to inhibit a murine derived TC-1 cell transformed with human papillomavirus 16 E6 and E7 growth in vitro. Caerin 1.9 inhibits TC-1 cell proliferation, although inhibition is more pronounced when applied in conjunction with caerin 1.1. To gain further insights into the antiproliferative mechanisms of caerin 1.9 and its additive effect with caerin 1.1, we used a proteomics strategy to quantitatively examine (i) the changes in the protein profiles of TC-1 cells and (ii) the excretory-secretory products of TC-1 cells following caerin peptides treatment. Caerin 1.9 treatment significantly altered the abundance of several immune-related proteins and related pathways, such as the Tec kinase and ILK signalling pathways, as well as the levels of proinflammatory cytokines and chemokines. In conclusion, caerin peptides inhibit TC-1 cell proliferation, associated with modification in signalling pathways that would change the tumour microenvironment which is normally immune suppressive." @default.
- W2799402272 created "2018-05-17" @default.
- W2799402272 creator A5002447978 @default.
- W2799402272 creator A5018866860 @default.
- W2799402272 creator A5019966262 @default.
- W2799402272 creator A5024010805 @default.
- W2799402272 creator A5039407086 @default.
- W2799402272 creator A5042860700 @default.
- W2799402272 creator A5045018467 @default.
- W2799402272 creator A5055905289 @default.
- W2799402272 creator A5066597852 @default.
- W2799402272 creator A5068222080 @default.
- W2799402272 creator A5072923976 @default.
- W2799402272 creator A5075945352 @default.
- W2799402272 date "2018-01-01" @default.
- W2799402272 modified "2023-10-18" @default.
- W2799402272 title "Comparative Proteomic Study of the Antiproliferative Activity of Frog Host-Defence Peptide Caerin 1.9 and Its Additive Effect with Caerin 1.1 on TC-1 Cells Transformed with HPV16 E6 and E7" @default.
- W2799402272 cites W1553155385 @default.
- W2799402272 cites W1557678369 @default.
- W2799402272 cites W1572220236 @default.
- W2799402272 cites W1761002785 @default.
- W2799402272 cites W1782512743 @default.
- W2799402272 cites W1870388044 @default.
- W2799402272 cites W1965694249 @default.
- W2799402272 cites W1974930131 @default.
- W2799402272 cites W1976424441 @default.
- W2799402272 cites W1981487040 @default.
- W2799402272 cites W1987213472 @default.
- W2799402272 cites W1987825791 @default.
- W2799402272 cites W1988049490 @default.
- W2799402272 cites W1993875664 @default.
- W2799402272 cites W1995168398 @default.
- W2799402272 cites W1998848324 @default.
- W2799402272 cites W2006771504 @default.
- W2799402272 cites W2009592988 @default.
- W2799402272 cites W2012979323 @default.
- W2799402272 cites W2015517299 @default.
- W2799402272 cites W2019777526 @default.
- W2799402272 cites W2021185175 @default.
- W2799402272 cites W2025422229 @default.
- W2799402272 cites W2034517648 @default.
- W2799402272 cites W2039380477 @default.
- W2799402272 cites W2048280438 @default.
- W2799402272 cites W204890274 @default.
- W2799402272 cites W2049391622 @default.
- W2799402272 cites W2051190668 @default.
- W2799402272 cites W2053463045 @default.
- W2799402272 cites W2054229004 @default.
- W2799402272 cites W2055456008 @default.
- W2799402272 cites W2056999366 @default.
- W2799402272 cites W2059041864 @default.
- W2799402272 cites W2059888416 @default.
- W2799402272 cites W2060178425 @default.
- W2799402272 cites W2068358300 @default.
- W2799402272 cites W2072066861 @default.
- W2799402272 cites W2072192494 @default.
- W2799402272 cites W2072630322 @default.
- W2799402272 cites W2074602656 @default.
- W2799402272 cites W2076253721 @default.
- W2799402272 cites W2080719056 @default.
- W2799402272 cites W2082058760 @default.
- W2799402272 cites W2085391208 @default.
- W2799402272 cites W2090703365 @default.
- W2799402272 cites W2097743822 @default.
- W2799402272 cites W2101432770 @default.
- W2799402272 cites W2106048352 @default.
- W2799402272 cites W2106665711 @default.
- W2799402272 cites W2109598625 @default.
- W2799402272 cites W2114970564 @default.
- W2799402272 cites W2122781293 @default.
- W2799402272 cites W2122835088 @default.
- W2799402272 cites W2123124042 @default.
- W2799402272 cites W2126882378 @default.
- W2799402272 cites W2130100167 @default.
- W2799402272 cites W2130974803 @default.
- W2799402272 cites W2131395371 @default.
- W2799402272 cites W2136316836 @default.
- W2799402272 cites W2138548798 @default.
- W2799402272 cites W2145120474 @default.
- W2799402272 cites W2148792419 @default.
- W2799402272 cites W2149074724 @default.
- W2799402272 cites W2152064969 @default.
- W2799402272 cites W2154353520 @default.
- W2799402272 cites W2156069524 @default.
- W2799402272 cites W2157757076 @default.
- W2799402272 cites W2158661194 @default.
- W2799402272 cites W2160110467 @default.
- W2799402272 cites W2170776626 @default.
- W2799402272 cites W2171027071 @default.
- W2799402272 cites W2171608750 @default.
- W2799402272 cites W2313048860 @default.
- W2799402272 cites W2313339984 @default.
- W2799402272 cites W2331093798 @default.
- W2799402272 cites W2341956178 @default.
- W2799402272 cites W2465087218 @default.
- W2799402272 cites W2783142245 @default.
- W2799402272 cites W308537902 @default.
- W2799402272 cites W4322701616 @default.