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• W2799409782 abstract "Summary Calorie restriction ( CR ) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH ‐dehydrogenases, namely NAD (P)H:quinone oxidoreductase 1 ( Nqo1 ) and cytochrome b 5 reductase 3 ( Cyb5r3 ), which provide electrons for energy metabolism. It has been proposed that this upregulation may be responsible for some of the beneficial effects of CR , and defects in their activity are linked to aging and several age‐associated diseases. However, it is unclear whether changes in metabolic homeostasis solely through upregulation of these NADH ‐dehydrogenases have a positive impact on health and survival. We generated a mouse that overexpresses both metabolic enzymes leading to phenotypes that resemble aspects of CR including a modest increase in lifespan, greater physical performance, a decrease in chronic inflammation, and, importantly, protection against carcinogenesis, one of the main hallmarks of CR . Furthermore, these animals showed an enhancement of metabolic flexibility and a significant upregulation of the NAD + /sirtuin pathway. The results highlight the importance of these NAD + producers for the promotion of health and extended lifespan." @default.
• W2799409782 created "2018-05-17" @default.
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• W2799409782 date "2018-04-28" @default.
• W2799409782 modified "2023-10-18" @default.
• W2799409782 title "Overexpression of CYB5R3 and NQO1, two NAD⁺ -producing enzymes, mimics aspects of caloric restriction" @default.
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• W2799409782 doi "https://doi.org/10.1111/acel.12767" @default.
• W2799409782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6052403" @default.
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