FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799415511> ?p ?o ?g. }

• W2799415511 endingPage "1175" @default.
• W2799415511 startingPage "1166" @default.
• W2799415511 abstract "Noxious stimulation at critical stages of development has long-term consequences on somatosensory processing in later life, but it is not known whether this developmental plasticity is restricted to nociceptive pathways. Here, we investigate the effect of repeated neonatal noxious or innocuous hind paw stimulation on adult spinal dorsal horn cutaneous mechanical sensitivity. Neonatal Sprague-Dawley rats of both sexes received 4 unilateral left hind paw needle pricks (NPs, n = 13) or 4 tactile (cotton swab touch) stimuli, per day (TC, n = 11) for the first 7 days of life. Control pups were left undisturbed (n = 17). When adult (6-8 weeks), lumbar wide-dynamic-range neuron activity in laminae III-V was recorded using in vivo extracellular single-unit electrophysiology. Spike activity evoked by cutaneous dynamic tactile (brush), pinch and punctate (von Frey hair) stimulation, and plantar receptive field areas were recorded, at baseline and 2 and 5 days after left plantar hind paw incision. Baseline brush receptive fields, von Frey hair, and pinch sensitivity were significantly enhanced in adult NP and TC animals compared with undisturbed controls, although effects were greatest in NP rats. After incision, injury sensitivity of adult wide-dynamic-range neurons to both noxious and dynamic tactile hypersensitivity was significantly greater in NP animals compared with TC and undisturbed controls. We conclude that both repeated touch and needle-prick stimulation in the neonatal period can alter adult spinal sensory neuron sensitivity to both innocuous and noxious mechanical stimulation. Thus, spinal sensory circuits underlying touch and pain processing are shaped by a range of early-life somatosensory experiences." @default.
• W2799415511 created "2018-05-17" @default.
• W2799415511 creator A5007034989 @default.
• W2799415511 creator A5008968519 @default.
• W2799415511 creator A5025255972 @default.
• W2799415511 creator A5026235423 @default.
• W2799415511 creator A5038423504 @default.
• W2799415511 creator A5078352024 @default.
• W2799415511 date "2018-03-16" @default.
• W2799415511 modified "2023-10-14" @default.
• W2799415511 title "Repeated touch and needle-prick stimulation in the neonatal period increases the baseline mechanical sensitivity and postinjury hypersensitivity of adult spinal sensory neurons" @default.
• W2799415511 cites W1527534059 @default.
• W2799415511 cites W1679166795 @default.
• W2799415511 cites W1755808881 @default.
• W2799415511 cites W1970035508 @default.
• W2799415511 cites W1970324625 @default.
• W2799415511 cites W1975653440 @default.
• W2799415511 cites W1977248443 @default.
• W2799415511 cites W1999117890 @default.
• W2799415511 cites W1999834026 @default.
• W2799415511 cites W2017462460 @default.
• W2799415511 cites W2023906412 @default.
• W2799415511 cites W2028521977 @default.
• W2799415511 cites W2034953779 @default.
• W2799415511 cites W2036747051 @default.
• W2799415511 cites W2040834941 @default.
• W2799415511 cites W2042316043 @default.
• W2799415511 cites W2046556055 @default.
• W2799415511 cites W2048444877 @default.
• W2799415511 cites W2059650428 @default.
• W2799415511 cites W2063837811 @default.
• W2799415511 cites W2064525989 @default.
• W2799415511 cites W2069045982 @default.
• W2799415511 cites W2070774084 @default.
• W2799415511 cites W2072968157 @default.
• W2799415511 cites W2075715972 @default.
• W2799415511 cites W2083875300 @default.
• W2799415511 cites W2085188038 @default.
• W2799415511 cites W2091069207 @default.
• W2799415511 cites W2091269069 @default.
• W2799415511 cites W2102414953 @default.
• W2799415511 cites W2104207514 @default.
• W2799415511 cites W2110053548 @default.
• W2799415511 cites W2119980381 @default.
• W2799415511 cites W2120677932 @default.
• W2799415511 cites W2126452889 @default.
• W2799415511 cites W2128692107 @default.
• W2799415511 cites W2129429506 @default.
• W2799415511 cites W2144078817 @default.
• W2799415511 cites W2149019366 @default.
• W2799415511 cites W2150096802 @default.
• W2799415511 cites W2153065561 @default.
• W2799415511 cites W2162104383 @default.
• W2799415511 cites W2169477863 @default.
• W2799415511 cites W2170240588 @default.
• W2799415511 cites W2276997237 @default.
• W2799415511 cites W2390672039 @default.
• W2799415511 cites W2471163435 @default.
• W2799415511 cites W2516111248 @default.
• W2799415511 cites W2561827989 @default.
• W2799415511 cites W2734706055 @default.
• W2799415511 cites W2758989439 @default.
• W2799415511 cites W4229548299 @default.
• W2799415511 cites W4367329911 @default.
• W2799415511 doi "https://doi.org/10.1097/j.pain.0000000000001201" @default.
• W2799415511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5959002" @default.
• W2799415511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29528964" @default.
• W2799415511 hasPublicationYear "2018" @default.
• W2799415511 type Work @default.
• W2799415511 sameAs 2799415511 @default.
• W2799415511 citedByCount "38" @default.
• W2799415511 countsByYear W27994155112018 @default.
• W2799415511 countsByYear W27994155112019 @default.
• W2799415511 countsByYear W27994155112020 @default.
• W2799415511 countsByYear W27994155112021 @default.
• W2799415511 countsByYear W27994155112022 @default.
• W2799415511 countsByYear W27994155112023 @default.
• W2799415511 crossrefType "journal-article" @default.
• W2799415511 hasAuthorship W2799415511A5007034989 @default.
• W2799415511 hasAuthorship W2799415511A5008968519 @default.
• W2799415511 hasAuthorship W2799415511A5025255972 @default.
• W2799415511 hasAuthorship W2799415511A5026235423 @default.
• W2799415511 hasAuthorship W2799415511A5038423504 @default.
• W2799415511 hasAuthorship W2799415511A5078352024 @default.
• W2799415511 hasBestOaLocation W27994155112 @default.
• W2799415511 hasConcept C104211972 @default.
• W2799415511 hasConcept C118552586 @default.
• W2799415511 hasConcept C126322002 @default.
• W2799415511 hasConcept C15490471 @default.
• W2799415511 hasConcept C15744967 @default.
• W2799415511 hasConcept C169760540 @default.
• W2799415511 hasConcept C170493617 @default.
• W2799415511 hasConcept C172497186 @default.
• W2799415511 hasConcept C172659308 @default.
• W2799415511 hasConcept C185263204 @default.
• W2799415511 hasConcept C19071747 @default.
• W2799415511 hasConcept C24998067 @default.
• W2799415511 hasConcept C25457674 @default.

• next