FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799435601> ?p ?o ?g. }

• W2799435601 endingPage "2555" @default.
• W2799435601 startingPage "2545" @default.
• W2799435601 abstract "Patterns of local failures and suggestions for reduction of clinical target volume for nasopharyngeal carcinoma patients without cervical lymph node metastasis Yujiao Li,1,2,* Xiaomin Ou,1,2,* Chunying Shen,1,2 Tingting Xu,1,2 Weiwei Li,1,2 Chaosu Hu1,2 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; 2Department of Oncology, Shanghai Medical College, Shanghai, China *These authors contributed equally to the paper Background: To demonstrate the robustness of clinical target volume delineation for nasopharyngeal carcinoma (NPC) patients, this study makes a detailed analysis of the initial irradiated dose of the recurrent site and local failure patterns after intensity-modulated radiation therapy (IMRT). Based on this analysis, further improvement of delineation recommendations may be made in order to improve the quality-of-life in NPC, without decreasing the local control and survival rate. Methods: In total, 382 newly diagnosed non-metastatic NPC patients were retrospectively enrolled, receiving elective neck irradiation to levels II, III, and VA. For patients with local failure, the location and extent of local failures were transferred to the pretreatment planning computed tomography (CT) for dosimetric analysis. The dose of radiation received by GTVr (gross tumor volume of recurrence) was calculated and analyzed with dose-volume histogram (DVH). Failures were classified as: “in field” if 95% of GTVr was within the 95% isodose, “marginal” if 20%–95% of GTVr was within the 95% isodose, or “outside” if less than 20% of GTVr was inside the 95% isodose. Results: With a median follow-up time of 61.3 months, 12 patients developed local recurrence (10 cases available). The 5-year overall survival, local relapse–free survival, regional relapse–free survival, distant metastasis failure–free survival, and disease–free survival were 87.8%, 95.2%, 99.1%, 93.3%, and 82.5%, respectively. Dose conformity with IMRT was excellent, and the recurrence was mainly within 3 years after the first treatment. The dosimetric analysis showed that seven failures were classified as “in-field”, two failures as “marginal”, and only one failure as “out-field”. Most local relapse sites located just the same site of primary tumor and most anatomic sites were at low risk of concurrent bilateral tumor invasion. Conclusions: IMRT with elective neck irradiation provides excellent local control for NPC patients without cervical lymph node metastasis. In-field failures are the main patterns for local recurrence, and the radioresistant subvolumes within the gross tumor volume are needed to be identified. This study proposed suggestions for reduction of target volume during IMRT treatment for NPC patients. Keywords: nasopharyngeal carcinoma, intensity-modulated radiotherapy, patterns of local failure, reduction of clinical target volume" @default.
• W2799435601 created "2018-05-17" @default.
• W2799435601 creator A5004104453 @default.
• W2799435601 creator A5017039148 @default.
• W2799435601 creator A5040287148 @default.
• W2799435601 creator A5079423095 @default.
• W2799435601 creator A5082529659 @default.
• W2799435601 creator A5085915806 @default.
• W2799435601 date "2018-05-01" @default.
• W2799435601 modified "2023-09-26" @default.
• W2799435601 title "Patterns of local failures and suggestions for reduction of clinical target volume for nasopharyngeal carcinoma patients without cervical lymph node metastasis" @default.
• W2799435601 cites W1555647250 @default.
• W2799435601 cites W1794669111 @default.
• W2799435601 cites W1987104299 @default.
• W2799435601 cites W2009262068 @default.
• W2799435601 cites W2011250897 @default.
• W2799435601 cites W2026201938 @default.
• W2799435601 cites W2037410430 @default.
• W2799435601 cites W2064419187 @default.
• W2799435601 cites W2079228270 @default.
• W2799435601 cites W2139389882 @default.
• W2799435601 cites W2145430644 @default.
• W2799435601 cites W2153725493 @default.
• W2799435601 cites W2154985581 @default.
• W2799435601 cites W2156837320 @default.
• W2799435601 cites W2159265144 @default.
• W2799435601 cites W2162486501 @default.
• W2799435601 cites W2193856897 @default.
• W2799435601 cites W2288945768 @default.
• W2799435601 cites W2550448147 @default.
• W2799435601 cites W2567143849 @default.
• W2799435601 doi "https://doi.org/10.2147/ott.s158126" @default.
• W2799435601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5944455" @default.
• W2799435601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29765233" @default.
• W2799435601 hasPublicationYear "2018" @default.
• W2799435601 type Work @default.
• W2799435601 sameAs 2799435601 @default.
• W2799435601 citedByCount "7" @default.
• W2799435601 countsByYear W27994356012019 @default.
• W2799435601 countsByYear W27994356012020 @default.
• W2799435601 countsByYear W27994356012022 @default.
• W2799435601 countsByYear W27994356012023 @default.
• W2799435601 crossrefType "journal-article" @default.
• W2799435601 hasAuthorship W2799435601A5004104453 @default.
• W2799435601 hasAuthorship W2799435601A5017039148 @default.
• W2799435601 hasAuthorship W2799435601A5040287148 @default.
• W2799435601 hasAuthorship W2799435601A5079423095 @default.
• W2799435601 hasAuthorship W2799435601A5082529659 @default.
• W2799435601 hasAuthorship W2799435601A5085915806 @default.
• W2799435601 hasBestOaLocation W27994356011 @default.
• W2799435601 hasConcept C121608353 @default.
• W2799435601 hasConcept C126322002 @default.
• W2799435601 hasConcept C126838900 @default.
• W2799435601 hasConcept C2778549279 @default.
• W2799435601 hasConcept C2778997737 @default.
• W2799435601 hasConcept C2779013556 @default.
• W2799435601 hasConcept C2780849966 @default.
• W2799435601 hasConcept C2989005 @default.
• W2799435601 hasConcept C509974204 @default.
• W2799435601 hasConcept C71924100 @default.
• W2799435601 hasConceptScore W2799435601C121608353 @default.
• W2799435601 hasConceptScore W2799435601C126322002 @default.
• W2799435601 hasConceptScore W2799435601C126838900 @default.
• W2799435601 hasConceptScore W2799435601C2778549279 @default.
• W2799435601 hasConceptScore W2799435601C2778997737 @default.
• W2799435601 hasConceptScore W2799435601C2779013556 @default.
• W2799435601 hasConceptScore W2799435601C2780849966 @default.
• W2799435601 hasConceptScore W2799435601C2989005 @default.
• W2799435601 hasConceptScore W2799435601C509974204 @default.
• W2799435601 hasConceptScore W2799435601C71924100 @default.
• W2799435601 hasLocation W27994356011 @default.
• W2799435601 hasLocation W27994356012 @default.
• W2799435601 hasLocation W27994356013 @default.
• W2799435601 hasLocation W27994356014 @default.
• W2799435601 hasOpenAccess W2799435601 @default.
• W2799435601 hasPrimaryLocation W27994356011 @default.
• W2799435601 hasRelatedWork W2374493286 @default.
• W2799435601 hasRelatedWork W2377320179 @default.
• W2799435601 hasRelatedWork W2386292109 @default.
• W2799435601 hasRelatedWork W2391975453 @default.
• W2799435601 hasRelatedWork W2392282050 @default.
• W2799435601 hasRelatedWork W2392638252 @default.
• W2799435601 hasRelatedWork W2465134912 @default.
• W2799435601 hasRelatedWork W3031701883 @default.
• W2799435601 hasRelatedWork W3031836888 @default.
• W2799435601 hasRelatedWork W3032219679 @default.
• W2799435601 hasVolume "Volume 11" @default.
• W2799435601 isParatext "false" @default.
• W2799435601 isRetracted "false" @default.
• W2799435601 magId "2799435601" @default.
• W2799435601 workType "article" @default.