FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799436701> ?p ?o ?g. }

• W2799436701 endingPage "751" @default.
• W2799436701 startingPage "746" @default.
• W2799436701 abstract "Bone turnover markers (BTMs) are proposed as alternative indicators for bone mineral density in diagnosis and management of osteoporosis. However, little is known about the effects of vitamin D supplementation on BTMs in nonwhite populations. We aimed to investigate the responses in BTMs after vitamin D supplementation in Asians. In this secondary data analysis of a randomized, double-blind, placebo-controlled trial, 448 Chinese adults [mean ± SD age: 31.9 ± 8.0 y; mean ± SD body mass index (kg/m2): 22.1 ± 2.6; 69% were women] with vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] <50 nmol/L) received 2000 IU/d cholecalciferol or placebo for 20 wk. Serum concentrations of 25(OH)D, parathyroid hormone (PTH), calcium, and markers of bone formation and resorption were measured at weeks 0 and 20. Intention-to-treat analysis was applied, and between-group differences were compared by general linear models with adjustments. Cholecalciferol supplementation increased the serum bone alkaline phosphatase (BALP) concentration (+1.7 ± 1.9 µg/L) significantly more than placebo (+1.1 ± 1.7 µg/L; P = 0.004), but not circulating concentrations of procollagen type I N-terminal propeptide (PINP), β-isomerized C-terminal telopeptide of type I collagen (β-CTX), or tartrate-resistant acid phosphatase 5b (TRAP5b) (P ≥ 0.53). Notably, a pooled analysis indicated that changes in serum 25(OH)D were positively associated with changes in serum BALP, PINP, and TRAP5b (r = 0.07–0.16, P ≤ 0.02), but inversely with changes in PTH (r = −0.15, P < 0.001). Among cholecalciferol-treated participants, individuals who achieved serum 25(OH)D ≥75 nmol/L had greater increases in serum β-CTX (224% compared with 146%; P = 0.02) and TRAP5b (22.2% compared with 9.1%; P = 0.007), but smaller decreases in serum calcium (−1.3% compared with −1.9%; P = 0.005) and calcium-phosphorus product (−2.6% compared with −3.3%; P = 0.02) compared with those with serum 25(OH)D <75 nmol/L. Daily supplementation with 2000 IU cholecalciferol for 20 wk may promote bone formation in Chinese adults with vitamin D deficiency. More studies are needed to elucidate the potential clinical implications of BTMs. This trial was registered at clinicaltrials.gov as NCT01998763." @default.
• W2799436701 created "2018-05-17" @default.
• W2799436701 creator A5002356988 @default.
• W2799436701 creator A5023519631 @default.
• W2799436701 creator A5050942675 @default.
• W2799436701 creator A5056298156 @default.
• W2799436701 creator A5081105290 @default.
• W2799436701 creator A5085673920 @default.
• W2799436701 date "2018-05-01" @default.
• W2799436701 modified "2023-10-04" @default.
• W2799436701 title "Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency" @default.
• W2799436701 cites W1169500588 @default.
• W2799436701 cites W1832304720 @default.
• W2799436701 cites W18924068 @default.
• W2799436701 cites W1965551846 @default.
• W2799436701 cites W1991346443 @default.
• W2799436701 cites W1993862887 @default.
• W2799436701 cites W2011861910 @default.
• W2799436701 cites W2020293276 @default.
• W2799436701 cites W2041310038 @default.
• W2799436701 cites W2041762053 @default.
• W2799436701 cites W2070176255 @default.
• W2799436701 cites W2073742622 @default.
• W2799436701 cites W2090411489 @default.
• W2799436701 cites W2097984614 @default.
• W2799436701 cites W2116192146 @default.
• W2799436701 cites W2118311305 @default.
• W2799436701 cites W2124070987 @default.
• W2799436701 cites W2128986278 @default.
• W2799436701 cites W2131264460 @default.
• W2799436701 cites W2133016139 @default.
• W2799436701 cites W2153059487 @default.
• W2799436701 cites W2165868202 @default.
• W2799436701 cites W2169322651 @default.
• W2799436701 cites W2534171399 @default.
• W2799436701 cites W2562985028 @default.
• W2799436701 cites W326642456 @default.
• W2799436701 doi "https://doi.org/10.1093/jn/nxy032" @default.
• W2799436701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29897564" @default.
• W2799436701 hasPublicationYear "2018" @default.
• W2799436701 type Work @default.
• W2799436701 sameAs 2799436701 @default.
• W2799436701 citedByCount "3" @default.
• W2799436701 countsByYear W27994367012021 @default.
• W2799436701 countsByYear W27994367012023 @default.
• W2799436701 crossrefType "journal-article" @default.
• W2799436701 hasAuthorship W2799436701A5002356988 @default.
• W2799436701 hasAuthorship W2799436701A5023519631 @default.
• W2799436701 hasAuthorship W2799436701A5050942675 @default.
• W2799436701 hasAuthorship W2799436701A5056298156 @default.
• W2799436701 hasAuthorship W2799436701A5081105290 @default.
• W2799436701 hasAuthorship W2799436701A5085673920 @default.
• W2799436701 hasBestOaLocation W27994367011 @default.
• W2799436701 hasConcept C124490489 @default.
• W2799436701 hasConcept C125870589 @default.
• W2799436701 hasConcept C126322002 @default.
• W2799436701 hasConcept C131075544 @default.
• W2799436701 hasConcept C134018914 @default.
• W2799436701 hasConcept C142724271 @default.
• W2799436701 hasConcept C160160445 @default.
• W2799436701 hasConcept C170033053 @default.
• W2799436701 hasConcept C181199279 @default.
• W2799436701 hasConcept C185592680 @default.
• W2799436701 hasConcept C204787440 @default.
• W2799436701 hasConcept C27081682 @default.
• W2799436701 hasConcept C2776541429 @default.
• W2799436701 hasConcept C2776886416 @default.
• W2799436701 hasConcept C2776941976 @default.
• W2799436701 hasConcept C2779740938 @default.
• W2799436701 hasConcept C2780106736 @default.
• W2799436701 hasConcept C2781208988 @default.
• W2799436701 hasConcept C519063684 @default.
• W2799436701 hasConcept C55493867 @default.
• W2799436701 hasConcept C673006 @default.
• W2799436701 hasConcept C71924100 @default.
• W2799436701 hasConceptScore W2799436701C124490489 @default.
• W2799436701 hasConceptScore W2799436701C125870589 @default.
• W2799436701 hasConceptScore W2799436701C126322002 @default.
• W2799436701 hasConceptScore W2799436701C131075544 @default.
• W2799436701 hasConceptScore W2799436701C134018914 @default.
• W2799436701 hasConceptScore W2799436701C142724271 @default.
• W2799436701 hasConceptScore W2799436701C160160445 @default.
• W2799436701 hasConceptScore W2799436701C170033053 @default.
• W2799436701 hasConceptScore W2799436701C181199279 @default.
• W2799436701 hasConceptScore W2799436701C185592680 @default.
• W2799436701 hasConceptScore W2799436701C204787440 @default.
• W2799436701 hasConceptScore W2799436701C27081682 @default.
• W2799436701 hasConceptScore W2799436701C2776541429 @default.
• W2799436701 hasConceptScore W2799436701C2776886416 @default.
• W2799436701 hasConceptScore W2799436701C2776941976 @default.
• W2799436701 hasConceptScore W2799436701C2779740938 @default.
• W2799436701 hasConceptScore W2799436701C2780106736 @default.
• W2799436701 hasConceptScore W2799436701C2781208988 @default.
• W2799436701 hasConceptScore W2799436701C519063684 @default.
• W2799436701 hasConceptScore W2799436701C55493867 @default.
• W2799436701 hasConceptScore W2799436701C673006 @default.
• W2799436701 hasConceptScore W2799436701C71924100 @default.
• W2799436701 hasIssue "5" @default.

• next