FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799440166> ?p ?o ?g. }

• W2799440166 abstract "Childhood maltreatment is associated with a wide range of psychopathologies including anxiety that emerge in childhood and in many cases persist in adulthood. Increased amygdala activation in response to threat and abnormal amygdala connectivity with frontolimbic brain regions, such as the hippocampus and the prefrontal cortex, are some of the most consistent findings seen in individuals exposed to childhood maltreatment. The underlying mechanisms responsible for these changes are difficult to study in humans but can be elucidated using animal models of early-life stress. Such studies are especially powerful in the mouse where precise control of the genetic background and the stress paradigm can be coupled with resting-state fMRI (rsfMRI) to map abnormal connectivity in circuits that regulate anxiety. To address this issue we first compared the effects of two models of early-life stress, limited bedding (LB) and unpredictable postnatal stress (UPS), on anxiety-like behavior in juvenile and adult mice. We found that UPS, but not LB, causes a robust increase in anxiety in juvenile and adult male mice. Next, we used rsfMRI to compare frontolimbic connectivity in control and UPS adult male mice. We found increased amygdala-prefrontal cortex and amygdala-hippocampus connectivity in UPS. The strength of the amygdala-hippocampal and amygdala-prefrontal cortex connectivity was highly correlated with anxiety-like behavior in the open-field test and elevated plus maze. These findings are the first to link hyperconnectivity in frontolimbic circuits and increased anxiety in a mouse model of early-life stress, allowing for more mechanistic understanding of parallel findings in humans." @default.
• W2799440166 created "2018-05-17" @default.
• W2799440166 creator A5002896292 @default.
• W2799440166 creator A5005312843 @default.
• W2799440166 creator A5007745108 @default.
• W2799440166 creator A5049882591 @default.
• W2799440166 creator A5050139699 @default.
• W2799440166 creator A5057921217 @default.
• W2799440166 creator A5077959963 @default.
• W2799440166 creator A5085513534 @default.
• W2799440166 date "2018-02-21" @default.
• W2799440166 modified "2023-10-16" @default.
• W2799440166 title "Amygdala hyper-connectivity in a mouse model of unpredictable early life stress" @default.
• W2799440166 cites W1015756911 @default.
• W2799440166 cites W1521312467 @default.
• W2799440166 cites W1553036094 @default.
• W2799440166 cites W1631193623 @default.
• W2799440166 cites W1719300997 @default.
• W2799440166 cites W1734357571 @default.
• W2799440166 cites W1891681766 @default.
• W2799440166 cites W1944272128 @default.
• W2799440166 cites W1973272857 @default.
• W2799440166 cites W1979046298 @default.
• W2799440166 cites W1980789245 @default.
• W2799440166 cites W1981459575 @default.
• W2799440166 cites W1985661446 @default.
• W2799440166 cites W1988059569 @default.
• W2799440166 cites W1988125482 @default.
• W2799440166 cites W1994014181 @default.
• W2799440166 cites W1997982013 @default.
• W2799440166 cites W1998226954 @default.
• W2799440166 cites W1998241928 @default.
• W2799440166 cites W1998274485 @default.
• W2799440166 cites W2002060477 @default.
• W2799440166 cites W2011081879 @default.
• W2799440166 cites W2011390414 @default.
• W2799440166 cites W2012250372 @default.
• W2799440166 cites W2015070843 @default.
• W2799440166 cites W2015671245 @default.
• W2799440166 cites W2030403813 @default.
• W2799440166 cites W2033631108 @default.
• W2799440166 cites W2033929686 @default.
• W2799440166 cites W2038138464 @default.
• W2799440166 cites W2041833534 @default.
• W2799440166 cites W2044820817 @default.
• W2799440166 cites W2046614450 @default.
• W2799440166 cites W2051458338 @default.
• W2799440166 cites W2052406842 @default.
• W2799440166 cites W2053774762 @default.
• W2799440166 cites W2058396187 @default.
• W2799440166 cites W2063400326 @default.
• W2799440166 cites W2064902953 @default.
• W2799440166 cites W2082161162 @default.
• W2799440166 cites W2106396500 @default.
• W2799440166 cites W2109186297 @default.
• W2799440166 cites W2109761979 @default.
• W2799440166 cites W2116839388 @default.
• W2799440166 cites W2117055846 @default.
• W2799440166 cites W2118714218 @default.
• W2799440166 cites W2119603000 @default.
• W2799440166 cites W2120184832 @default.
• W2799440166 cites W2120911948 @default.
• W2799440166 cites W2125029186 @default.
• W2799440166 cites W2127436676 @default.
• W2799440166 cites W2130424909 @default.
• W2799440166 cites W2139776814 @default.
• W2799440166 cites W2140775007 @default.
• W2799440166 cites W2141124547 @default.
• W2799440166 cites W2145223707 @default.
• W2799440166 cites W2156159028 @default.
• W2799440166 cites W2160028381 @default.
• W2799440166 cites W2160546880 @default.
• W2799440166 cites W2166372248 @default.
• W2799440166 cites W2266560836 @default.
• W2799440166 cites W2290190425 @default.
• W2799440166 cites W2403252035 @default.
• W2799440166 cites W2419356453 @default.
• W2799440166 cites W2535572695 @default.
• W2799440166 cites W2557111525 @default.
• W2799440166 cites W2566196214 @default.
• W2799440166 cites W2566690600 @default.
• W2799440166 cites W2574877967 @default.
• W2799440166 cites W2579780502 @default.
• W2799440166 cites W2587922926 @default.
• W2799440166 cites W2596601118 @default.
• W2799440166 cites W2627020071 @default.
• W2799440166 cites W2736440051 @default.
• W2799440166 cites W2765768174 @default.
• W2799440166 doi "https://doi.org/10.1038/s41398-018-0092-z" @default.
• W2799440166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5820270" @default.
• W2799440166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29463821" @default.
• W2799440166 hasPublicationYear "2018" @default.
• W2799440166 type Work @default.
• W2799440166 sameAs 2799440166 @default.
• W2799440166 citedByCount "79" @default.
• W2799440166 countsByYear W27994401662018 @default.
• W2799440166 countsByYear W27994401662019 @default.
• W2799440166 countsByYear W27994401662020 @default.
• W2799440166 countsByYear W27994401662021 @default.
• W2799440166 countsByYear W27994401662022 @default.

• next