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• W2799441483 abstract "Infectious diseases are a significant issue in animal production systems, including both the dairy and beef cattle industries. Understanding and defining the genetics of infectious disease susceptibility in cattle is an important step in the mitigation of their impact. Collagenous lectins are soluble pattern recognition receptors that form an important part of the innate immune system, which serves as the first line of host defense against pathogens. Polymorphisms in the collagenous lectin genes have been shown in previous studies to contribute to infectious disease susceptibility, and in cattle, mutations in two collagenous lectin genes (MBL1 and MBL2) are associated with mastitis. To further characterize the contribution of variation in the bovine collagenous lectins to infectious disease susceptibility, we used a pooled NGS approach to identify short nucleotide variants (SNVs) in the collagenous lectins (and regulatory DNA) of cattle with (n = 80) and without (n = 40) infectious disease. Allele frequency analysis identified 74 variants that were significantly (p < 5 × 10−6) associated with infectious disease, the majority of which were clustered in a 29-kb segment upstream of the collectin locus on chromosome 28. In silico analysis of the functional effects of all the variants predicted 11 SNVs with a deleterious effect on protein structure and/or function, 148 SNVs that occurred within potential transcription factor binding sites, and 31 SNVs occurring within potential miRNA binding elements. This study provides a detailed look at the genetic variation of the bovine collagenous lectins and identifies potential genetic markers for infectious disease susceptibility." @default.
• W2799441483 created "2018-05-17" @default.
• W2799441483 creator A5004570381 @default.
• W2799441483 creator A5039116149 @default.
• W2799441483 creator A5040568531 @default.
• W2799441483 date "2018-05-10" @default.
• W2799441483 modified "2023-09-25" @default.
• W2799441483 title "Identification of polymorphisms in the bovine collagenous lectins and their association with infectious diseases in cattle" @default.
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• W2799441483 doi "https://doi.org/10.1007/s00251-018-1061-7" @default.
• W2799441483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6061482" @default.
• W2799441483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29744529" @default.
• W2799441483 hasPublicationYear "2018" @default.
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