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• W2799446522 abstract "The primary objective of the study was to evaluate the effect of a hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), on biomarkers in adults with nonalcoholic fatty liver disease (NAFLD). A 90-day randomized double-blind placebo-controlled trial examined the effect of RBAC on complete blood count, liver enzymes, lipids, oxidative stress markers, cytokines, and growth factors. Twenty-three adults with NAFLD were enrolled and randomly assigned to one of the two study conditions (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>12</mml:mn></mml:math> RBAC and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>11</mml:mn></mml:math> placebo) and consumed 1 gram/day of either compound for 90 days. Subjects were assessed at baseline and 45 and 90 days. No adverse effects were reported. Alkaline phosphatase significantly decreased (−3.1%; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>D</mml:mi><mml:mo>=</mml:mo><mml:mn mathvariant=normal>19.9</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>F</mml:mi><mml:mo stretchy=false>[</mml:mo><mml:mn fontstyle=italic>1,19</mml:mn><mml:mo stretchy=false>]</mml:mo><mml:mo>=</mml:mo><mml:mn fontstyle=italic>5.1</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.03</mml:mn></mml:math>) in the RBAC group compared to the placebo group. The percentages of monocytes (17.9%; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>D</mml:mi><mml:mo>=</mml:mo><mml:mn mathvariant=normal>18.3</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>F</mml:mi><mml:mo stretchy=false>[</mml:mo><mml:mn fontstyle=italic>1,19</mml:mn><mml:mo stretchy=false>]</mml:mo><mml:mo>=</mml:mo><mml:mn fontstyle=italic>5.9</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.02</mml:mn></mml:math>) and eosinophils (30.6%; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>D</mml:mi><mml:mo>=</mml:mo><mml:mn mathvariant=normal>30.5</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>F</mml:mi><mml:mo stretchy=false>[</mml:mo><mml:mn fontstyle=italic>1,19</mml:mn><mml:mo stretchy=false>]</mml:mo><mml:mo>=</mml:mo><mml:mn fontstyle=italic>12.3</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.01</mml:mn></mml:math>) increased in the RBAC group. IFN-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math> (156%; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>D</mml:mi><mml:mo>=</mml:mo><mml:mn mathvariant=normal>131.8</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mi>F</mml:mi><mml:mo stretchy=false>[</mml:mo><mml:mn fontstyle=italic>1,19</mml:mn><mml:mo stretchy=false>]</mml:mo><mml:mo>=</mml:mo><mml:mn fontstyle=italic>4.2</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.06</mml:mn></mml:math>) and IL-18 (29.1%; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>D</mml:mi><mml:mo>=</mml:mo><mml:mn mathvariant=normal>64</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M17><mml:mi>F</mml:mi><mml:mo stretchy=false>[</mml:mo><mml:mn fontstyle=italic>1,19</mml:mn><mml:mo stretchy=false>]</mml:mo><mml:mo>=</mml:mo><mml:mn fontstyle=italic>5.3</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M18><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.03</mml:mn></mml:math>) increased in the RBAC group compared to the placebo group. Other improvements were noted for platelets, neutrophils, neutrophil-lymphocyte ratio, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M19><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>-glutamyl transferase, and 4-hydroxynonenal. RBAC had beneficial effects on several biomarkers that adds to the known immunomodulatory activities of RBAC, which may be promising for people with NAFLD." @default.
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• W2799446522 date "2018-05-03" @default.
• W2799446522 modified "2023-09-29" @default.
• W2799446522 title "The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease" @default.
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• W2799446522 doi "https://doi.org/10.1155/2018/1751583" @default.
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