FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799446972> ?p ?o ?g. }

• W2799446972 endingPage "337" @default.
• W2799446972 startingPage "327" @default.
• W2799446972 abstract "Cerebrospinal fluid (CSF) is a key body fluid that maintains the homeostasis in central nervous system (CNS). As a biofluid whose content reflects the brain metabolic activity, the CSF has been profiled in the context of neurological diseases to provide novel insights into the disease mechanisms. However, a global high-throughput approach to measure a broad diversity of polar metabolites present in CSF is lacking. Although still perceived as challenging and less reproducible, hydrophilic interaction liquid chromatography (HILIC) has recently evolved to offer the unprecedented coverage capacity of water-soluble metabolome. Here, we present a global HILIC high-resolution mass spectrometry-based (HRMS) approach that combines the profiling in acidic pH ESI (+) and basic pH ESI (−) mode to extend the coverage of CSF polar metabolome. This approach allowed us to annotate and measure a broad range of central carbon metabolites (implicated in glycolysis, TCA cycle, nucleotide, amino acid and fatty acid metabolism) in CSF collected from cognitively healthy elderly volunteers (n = 32), using a single extraction method. Metabolite annotation was achieved using the accurate mass, RT and MS/MS criteria, allowing for the characterization of 146 measurable metabolites. Exploration of characterized individual CSF profiles allowed for a discovery of intriguing gender-associated differences, with significantly higher acylcarnitine levels in men and higher taurine levels women. With this case study, we demonstrate the value of combined HILIC ESI ± HRMS profiling to assess CSF metabolome in clinical research studies." @default.
• W2799446972 created "2018-05-17" @default.
• W2799446972 creator A5013760989 @default.
• W2799446972 creator A5017135540 @default.
• W2799446972 creator A5022295403 @default.
• W2799446972 creator A5068393615 @default.
• W2799446972 creator A5071714131 @default.
• W2799446972 creator A5071891017 @default.
• W2799446972 creator A5077405324 @default.
• W2799446972 creator A5083697454 @default.
• W2799446972 creator A5089048513 @default.
• W2799446972 date "2018-12-01" @default.
• W2799446972 modified "2023-10-16" @default.
• W2799446972 title "A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects" @default.
• W2799446972 cites W1084497830 @default.
• W2799446972 cites W1507549456 @default.
• W2799446972 cites W1708297083 @default.
• W2799446972 cites W1952539308 @default.
• W2799446972 cites W1964010911 @default.
• W2799446972 cites W1995543670 @default.
• W2799446972 cites W1997062226 @default.
• W2799446972 cites W2006315039 @default.
• W2799446972 cites W2013233148 @default.
• W2799446972 cites W2023535481 @default.
• W2799446972 cites W2037136746 @default.
• W2799446972 cites W2045721814 @default.
• W2799446972 cites W2046965677 @default.
• W2799446972 cites W2063028213 @default.
• W2799446972 cites W2066538400 @default.
• W2799446972 cites W2069855448 @default.
• W2799446972 cites W2073939393 @default.
• W2799446972 cites W2078583253 @default.
• W2799446972 cites W2080046774 @default.
• W2799446972 cites W2081311904 @default.
• W2799446972 cites W2092115703 @default.
• W2799446972 cites W2098157576 @default.
• W2799446972 cites W2098667036 @default.
• W2799446972 cites W2101659988 @default.
• W2799446972 cites W2105381419 @default.
• W2799446972 cites W2118925636 @default.
• W2799446972 cites W2125575989 @default.
• W2799446972 cites W2149309843 @default.
• W2799446972 cites W2159671087 @default.
• W2799446972 cites W2159819304 @default.
• W2799446972 cites W2162539049 @default.
• W2799446972 cites W2215675716 @default.
• W2799446972 cites W2252893442 @default.
• W2799446972 cites W2271911760 @default.
• W2799446972 cites W2296877449 @default.
• W2799446972 cites W2324021033 @default.
• W2799446972 cites W2334617819 @default.
• W2799446972 cites W2343357155 @default.
• W2799446972 cites W2471107259 @default.
• W2799446972 cites W2485242069 @default.
• W2799446972 cites W2523233421 @default.
• W2799446972 cites W2585474145 @default.
• W2799446972 cites W2625767007 @default.
• W2799446972 cites W2626775758 @default.
• W2799446972 cites W2735452220 @default.
• W2799446972 cites W2750498011 @default.
• W2799446972 cites W2766694562 @default.
• W2799446972 doi "https://doi.org/10.1016/j.aca.2018.04.002" @default.
• W2799446972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30292309" @default.
• W2799446972 hasPublicationYear "2018" @default.
• W2799446972 type Work @default.
• W2799446972 sameAs 2799446972 @default.
• W2799446972 citedByCount "49" @default.
• W2799446972 countsByYear W27994469722018 @default.
• W2799446972 countsByYear W27994469722019 @default.
• W2799446972 countsByYear W27994469722020 @default.
• W2799446972 countsByYear W27994469722021 @default.
• W2799446972 countsByYear W27994469722022 @default.
• W2799446972 countsByYear W27994469722023 @default.
• W2799446972 crossrefType "journal-article" @default.
• W2799446972 hasAuthorship W2799446972A5013760989 @default.
• W2799446972 hasAuthorship W2799446972A5017135540 @default.
• W2799446972 hasAuthorship W2799446972A5022295403 @default.
• W2799446972 hasAuthorship W2799446972A5068393615 @default.
• W2799446972 hasAuthorship W2799446972A5071714131 @default.
• W2799446972 hasAuthorship W2799446972A5071891017 @default.
• W2799446972 hasAuthorship W2799446972A5077405324 @default.
• W2799446972 hasAuthorship W2799446972A5083697454 @default.
• W2799446972 hasAuthorship W2799446972A5089048513 @default.
• W2799446972 hasConcept C116817701 @default.
• W2799446972 hasConcept C135870905 @default.
• W2799446972 hasConcept C151730666 @default.
• W2799446972 hasConcept C15744967 @default.
• W2799446972 hasConcept C162356407 @default.
• W2799446972 hasConcept C169760540 @default.
• W2799446972 hasConcept C179998833 @default.
• W2799446972 hasConcept C185592680 @default.
• W2799446972 hasConcept C21565614 @default.
• W2799446972 hasConcept C2777477808 @default.
• W2799446972 hasConcept C2779343474 @default.
• W2799446972 hasConcept C2779651940 @default.
• W2799446972 hasConcept C2779701627 @default.
• W2799446972 hasConcept C31827203 @default.
• W2799446972 hasConcept C43617362 @default.

• next