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• W2799455764 startingPage "234" @default.
• W2799455764 abstract "Selection is expected to work differently in autosomal and X-linked genes because of their ploidy difference and the exposure of recessive X-linked mutations to haploid selection in males. However, it is not clear whether these expectations apply to recently evolved sex chromosomes, where many genes retain functional X- and Y-linked gametologs. We took advantage of the recently evolved sex chromosomes in the plant Silene latifolia and its closely related species to compare the selective pressures between hemizygous and non-hemizygous X-linked genes as well as between X-linked genes and autosomal genes. Our analysis, based on over 1000 genes, demonstrated that, similar to animals, X-linked genes in Silene evolve significantly faster than autosomal genes—the so-called faster-X effect. Contrary to expectations, faster-X divergence was detectable only for non-hemizygous X-linked genes. Our phylogeny-based analyses of selection revealed no evidence for faster adaptation in X-linked genes compared to autosomal genes. On the other hand, partial relaxation of purifying selection was apparent on the X-chromosome compared to the autosomes, consistent with a smaller genetic diversity in S. latifolia X-linked genes (πx = 0.016; πaut = 0.023). Thus, the faster-X divergence in S. latifolia appears to be a consequence of the smaller effective population size rather than of a faster adaptive evolution on the X-chromosome. We argue that this may be a general feature of “young” sex chromosomes, where the majority of X-linked genes are not hemizygous, preventing haploid selection in heterogametic sex." @default.
• W2799455764 created "2018-05-17" @default.
• W2799455764 creator A5000280977 @default.
• W2799455764 creator A5031780157 @default.
• W2799455764 creator A5088644737 @default.
• W2799455764 date "2018-05-03" @default.
• W2799455764 modified "2023-09-25" @default.
• W2799455764 title "A Comparison of Selective Pressures in Plant X-Linked and Autosomal Genes" @default.
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• W2799455764 doi "https://doi.org/10.3390/genes9050234" @default.
• W2799455764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5977174" @default.
• W2799455764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29751495" @default.
• W2799455764 hasPublicationYear "2018" @default.
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