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- W2799483977 endingPage "699" @default.
- W2799483977 startingPage "690" @default.
- W2799483977 abstract "The circadian clock consists of negative and positive transcriptional and translational feedback loops present in the genome that cause a rhythmic oscillation of the expression of genes involved in regulating a vast proportion of physiological processes in mammals. The endogenous diurnal rhythms of the master circadian clock in the brain have a period of roughly 24.5 h, and the same rhythms can be observed in peripheral clocks present in individual cells of many tissues. Like a watch that needs daily adjustments, environmental cues such as light and food intake are able to entrain the central and peripheral clocks to match the requirements of the life routine of an individual. When conflicting or erratic environmental cues, typical of our civilized life, produce aberrant circadian rhythms that are no longer in synchrony with metabolic or physiological demands, health issues including obesity, metabolic disease, sleep disorders and cancer can arise. An overview of the molecular basis of the circadian central and peripheral clocks at the intersection with regulatory proteins involved in metabolic and epigenetic modulation of circadian rhythms provides some rationale why these diseases occur, particularly in, but not limited to, night time and shift workers." @default.
- W2799483977 created "2018-05-17" @default.
- W2799483977 creator A5046079930 @default.
- W2799483977 creator A5046788005 @default.
- W2799483977 date "2019-01-01" @default.
- W2799483977 modified "2023-09-26" @default.
- W2799483977 title "Circadian Clock, Epigenetic Regulators (Sirtuins), and Metabolism" @default.
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