Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799488889> ?p ?o ?g. }
- W2799488889 endingPage "592" @default.
- W2799488889 startingPage "586" @default.
- W2799488889 abstract "Nanosponges are a novel class of hyperbranched cyclodextrin-based nanostructures that exhibits remarkable potential as a drug host system for the improvement in biopharmaceutical properties. This work aims the development of cyclodextrin-based nanosponge of norfloxacin to improve its physicochemical characteristics. β-cyclodextrin was used as base and diphenyl carbonate as crosslinker agent at different proportions to produce nanosponges that were evaluated by in vitro and in vivo techniques. The proportion cyclodextrin:crosslinker 1:2 M/M was chosen due to its higher encapsulation efficiency (80%), revealing an average diameter size of 40 nm with zeta potential of −19 mV. Norfloxacin-loaded nanosponges exhibited higher passage of norfloxacin in comparison to norfloxacin drug alone by Ussing chamber method. The nanosponge formulation also revealed a mucoadhesive property that could increase norfloxacin absorption thus improving its antibiotic activity in an in vivo sepsis model. Therefore, nanosponges may be suitable carrier of norfloxacin to maximize and facilitate oral absorption." @default.
- W2799488889 created "2018-05-17" @default.
- W2799488889 creator A5003933795 @default.
- W2799488889 creator A5005886154 @default.
- W2799488889 creator A5025737479 @default.
- W2799488889 creator A5040454468 @default.
- W2799488889 creator A5040925076 @default.
- W2799488889 creator A5047419237 @default.
- W2799488889 date "2018-09-01" @default.
- W2799488889 modified "2023-10-17" @default.
- W2799488889 title "Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity" @default.
- W2799488889 cites W1866287733 @default.
- W2799488889 cites W1966335602 @default.
- W2799488889 cites W1981645618 @default.
- W2799488889 cites W1991968794 @default.
- W2799488889 cites W2019610958 @default.
- W2799488889 cites W2033025383 @default.
- W2799488889 cites W2035391560 @default.
- W2799488889 cites W2036162895 @default.
- W2799488889 cites W2041880062 @default.
- W2799488889 cites W2043825921 @default.
- W2799488889 cites W2048253785 @default.
- W2799488889 cites W2052244316 @default.
- W2799488889 cites W2058732924 @default.
- W2799488889 cites W2061963139 @default.
- W2799488889 cites W2068903617 @default.
- W2799488889 cites W2086862244 @default.
- W2799488889 cites W2118858814 @default.
- W2799488889 cites W2134654895 @default.
- W2799488889 cites W2145451520 @default.
- W2799488889 cites W2171144560 @default.
- W2799488889 cites W2395125555 @default.
- W2799488889 cites W2563228880 @default.
- W2799488889 cites W2618376493 @default.
- W2799488889 cites W2770406793 @default.
- W2799488889 cites W2789619602 @default.
- W2799488889 cites W2793485037 @default.
- W2799488889 cites W2794213780 @default.
- W2799488889 cites W4237268340 @default.
- W2799488889 doi "https://doi.org/10.1016/j.carbpol.2018.05.011" @default.
- W2799488889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29805015" @default.
- W2799488889 hasPublicationYear "2018" @default.
- W2799488889 type Work @default.
- W2799488889 sameAs 2799488889 @default.
- W2799488889 citedByCount "36" @default.
- W2799488889 countsByYear W27994888892019 @default.
- W2799488889 countsByYear W27994888892020 @default.
- W2799488889 countsByYear W27994888892021 @default.
- W2799488889 countsByYear W27994888892022 @default.
- W2799488889 countsByYear W27994888892023 @default.
- W2799488889 crossrefType "journal-article" @default.
- W2799488889 hasAuthorship W2799488889A5003933795 @default.
- W2799488889 hasAuthorship W2799488889A5005886154 @default.
- W2799488889 hasAuthorship W2799488889A5025737479 @default.
- W2799488889 hasAuthorship W2799488889A5040454468 @default.
- W2799488889 hasAuthorship W2799488889A5040925076 @default.
- W2799488889 hasAuthorship W2799488889A5047419237 @default.
- W2799488889 hasBestOaLocation W27994888891 @default.
- W2799488889 hasConcept C125287762 @default.
- W2799488889 hasConcept C150903083 @default.
- W2799488889 hasConcept C155672457 @default.
- W2799488889 hasConcept C159985019 @default.
- W2799488889 hasConcept C171250308 @default.
- W2799488889 hasConcept C181389837 @default.
- W2799488889 hasConcept C185592680 @default.
- W2799488889 hasConcept C192562407 @default.
- W2799488889 hasConcept C207001950 @default.
- W2799488889 hasConcept C2778512257 @default.
- W2799488889 hasConcept C2778746504 @default.
- W2799488889 hasConcept C2779433975 @default.
- W2799488889 hasConcept C3019249092 @default.
- W2799488889 hasConcept C41625074 @default.
- W2799488889 hasConcept C43617362 @default.
- W2799488889 hasConcept C501593827 @default.
- W2799488889 hasConcept C50670333 @default.
- W2799488889 hasConcept C55493867 @default.
- W2799488889 hasConcept C71924100 @default.
- W2799488889 hasConcept C86181022 @default.
- W2799488889 hasConcept C86803240 @default.
- W2799488889 hasConcept C98274493 @default.
- W2799488889 hasConceptScore W2799488889C125287762 @default.
- W2799488889 hasConceptScore W2799488889C150903083 @default.
- W2799488889 hasConceptScore W2799488889C155672457 @default.
- W2799488889 hasConceptScore W2799488889C159985019 @default.
- W2799488889 hasConceptScore W2799488889C171250308 @default.
- W2799488889 hasConceptScore W2799488889C181389837 @default.
- W2799488889 hasConceptScore W2799488889C185592680 @default.
- W2799488889 hasConceptScore W2799488889C192562407 @default.
- W2799488889 hasConceptScore W2799488889C207001950 @default.
- W2799488889 hasConceptScore W2799488889C2778512257 @default.
- W2799488889 hasConceptScore W2799488889C2778746504 @default.
- W2799488889 hasConceptScore W2799488889C2779433975 @default.
- W2799488889 hasConceptScore W2799488889C3019249092 @default.
- W2799488889 hasConceptScore W2799488889C41625074 @default.
- W2799488889 hasConceptScore W2799488889C43617362 @default.
- W2799488889 hasConceptScore W2799488889C501593827 @default.
- W2799488889 hasConceptScore W2799488889C50670333 @default.
- W2799488889 hasConceptScore W2799488889C55493867 @default.