FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799514384> ?p ?o ?g. }

• W2799514384 endingPage "G271" @default.
• W2799514384 startingPage "G259" @default.
• W2799514384 abstract "The intestinal barrier is often disrupted in disease states, and intestinal barrier failure leads to sepsis. Ursodeoxycholic acid (UDCA) is a bile acid that may protect the intestinal barrier. We hypothesized that UDCA would protect the intestinal epithelium in injury models. To test this hypothesis, we utilized an in vitro wound-healing assay and a mouse model of intestinal barrier injury. We found that UDCA stimulates intestinal epithelial cell migration in vitro, and this migration was blocked by inhibition of cyclooxygenase 2 (COX-2), epidermal growth factor receptor (EGFR), or ERK. Furthermore, UDCA stimulated both COX-2 induction and EGFR phosphorylation. In vivo UDCA protected the intestinal barrier from LPS-induced injury as measured by FITC dextran leakage into the serum. Using 5-bromo-2'-deoxyuridine and 5-ethynyl-2'-deoxyuridine injections, we found that UDCA stimulated intestinal epithelial cell migration in these animals. These effects were blocked with either administration of Rofecoxib, a COX-2 inhibitor, or in EGFR-dominant negative Velvet mice, wherein UDCA had no effect on LPS-induced injury. Finally, we found increased COX-2 and phosphorylated ERK levels in LPS animals also treated with UDCA. Taken together, these data suggest that UDCA can stimulate intestinal epithelial cell migration and protect against acute intestinal injury via an EGFR- and COX-2-dependent mechanism. UDCA may be an effective treatment to prevent the early onset of gut-origin sepsis. NEW & NOTEWORTHY In this study, we show that the secondary bile acid ursodeoxycholic acid stimulates intestinal epithelial cell migration after cellular injury and also protects the intestinal barrier in an acute rodent injury model, neither of which has been previously reported. These effects are dependent on epidermal growth factor receptor activation and downstream cyclooxygenase 2 upregulation in the small intestine. This provides a potential treatment for acute, gut-origin sepsis as seen in diseases such as necrotizing enterocolitis." @default.
• W2799514384 created "2018-05-17" @default.
• W2799514384 creator A5012727802 @default.
• W2799514384 creator A5018359219 @default.
• W2799514384 creator A5029314947 @default.
• W2799514384 creator A5031359568 @default.
• W2799514384 creator A5065194210 @default.
• W2799514384 creator A5066649441 @default.
• W2799514384 creator A5070886590 @default.
• W2799514384 date "2018-08-01" @default.
• W2799514384 modified "2023-10-18" @default.
• W2799514384 title "Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms" @default.
• W2799514384 cites W1808736595 @default.
• W2799514384 cites W1900120061 @default.
• W2799514384 cites W1937309330 @default.
• W2799514384 cites W1963975982 @default.
• W2799514384 cites W1965831124 @default.
• W2799514384 cites W1967980869 @default.
• W2799514384 cites W1969792883 @default.
• W2799514384 cites W1971590777 @default.
• W2799514384 cites W1983054413 @default.
• W2799514384 cites W198432786 @default.
• W2799514384 cites W1999435777 @default.
• W2799514384 cites W2000675841 @default.
• W2799514384 cites W2007769088 @default.
• W2799514384 cites W2011269641 @default.
• W2799514384 cites W2012136453 @default.
• W2799514384 cites W2016117582 @default.
• W2799514384 cites W2016821559 @default.
• W2799514384 cites W2017422805 @default.
• W2799514384 cites W2017929099 @default.
• W2799514384 cites W2021632992 @default.
• W2799514384 cites W2037901495 @default.
• W2799514384 cites W2040542666 @default.
• W2799514384 cites W2054979785 @default.
• W2799514384 cites W2069102453 @default.
• W2799514384 cites W2072852259 @default.
• W2799514384 cites W2073205471 @default.
• W2799514384 cites W2076560206 @default.
• W2799514384 cites W2084002971 @default.
• W2799514384 cites W2087228124 @default.
• W2799514384 cites W2092200219 @default.
• W2799514384 cites W2098182051 @default.
• W2799514384 cites W2103038927 @default.
• W2799514384 cites W2103272211 @default.
• W2799514384 cites W2104933407 @default.
• W2799514384 cites W2106293055 @default.
• W2799514384 cites W2109564163 @default.
• W2799514384 cites W2110044148 @default.
• W2799514384 cites W2117734033 @default.
• W2799514384 cites W2124723056 @default.
• W2799514384 cites W2126413018 @default.
• W2799514384 cites W2126504523 @default.
• W2799514384 cites W2130896556 @default.
• W2799514384 cites W2133403920 @default.
• W2799514384 cites W2134354994 @default.
• W2799514384 cites W2142578122 @default.
• W2799514384 cites W2143369970 @default.
• W2799514384 cites W2145214511 @default.
• W2799514384 cites W2149511051 @default.
• W2799514384 cites W2165683179 @default.
• W2799514384 cites W2167279371 @default.
• W2799514384 cites W2186781473 @default.
• W2799514384 cites W2189051117 @default.
• W2799514384 cites W2295213040 @default.
• W2799514384 cites W2318114334 @default.
• W2799514384 cites W2415733850 @default.
• W2799514384 cites W2598445433 @default.
• W2799514384 cites W2613847425 @default.
• W2799514384 cites W2419649978 @default.
• W2799514384 doi "https://doi.org/10.1152/ajpgi.00354.2017" @default.
• W2799514384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139640" @default.
• W2799514384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29672156" @default.
• W2799514384 hasPublicationYear "2018" @default.
• W2799514384 type Work @default.
• W2799514384 sameAs 2799514384 @default.
• W2799514384 citedByCount "33" @default.
• W2799514384 countsByYear W27995143842019 @default.
• W2799514384 countsByYear W27995143842020 @default.
• W2799514384 countsByYear W27995143842021 @default.
• W2799514384 countsByYear W27995143842022 @default.
• W2799514384 countsByYear W27995143842023 @default.
• W2799514384 crossrefType "journal-article" @default.
• W2799514384 hasAuthorship W2799514384A5012727802 @default.
• W2799514384 hasAuthorship W2799514384A5018359219 @default.
• W2799514384 hasAuthorship W2799514384A5029314947 @default.
• W2799514384 hasAuthorship W2799514384A5031359568 @default.
• W2799514384 hasAuthorship W2799514384A5065194210 @default.
• W2799514384 hasAuthorship W2799514384A5066649441 @default.
• W2799514384 hasAuthorship W2799514384A5070886590 @default.
• W2799514384 hasBestOaLocation W27995143841 @default.
• W2799514384 hasConcept C126322002 @default.
• W2799514384 hasConcept C142724271 @default.
• W2799514384 hasConcept C185592680 @default.
• W2799514384 hasConcept C2777882243 @default.
• W2799514384 hasConcept C2779399885 @default.
• W2799514384 hasConcept C2779604457 @default.
• W2799514384 hasConcept C2780749602 @default.

• next