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• W2799571961 abstract "Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring. In a healthy, community-based sub-sample (n = 350) of reproductive age participants in the OVA Study (2006–2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Prenatal maternal SES was assessed indirectly using maternal addresses abstracted from participant birth certificates, geocoded, and linked to US Census-derived variables, including neighborhood-level characteristics: education (% of individuals with a HS diploma); poverty (% of families below the poverty line); unemployment (% of individuals > 16 years who are unemployed); and income (median family income). In separate covariate-adjusted linear regression models (following the backward elimination of main effects with P > .10), greater maternal neighborhood education was related to higher ovarian reserve as marked by higher levels of offspring AMH (beta = .142, P < .001) and AFC (beta = .092, P < .10) with models accounting for 19.6% and 21.5% of the variance in AMH and AFC, respectively. In addition, greater maternal neighborhood poverty was related to lower ovarian reserve as marked by lower offspring AMH (beta = −.144, P < .01), with the model accounting for 19.5% of the variance in AMH. Maternal socioeconomic disadvantage measured indirectly at the neighborhood level was associated with lower ovarian reserve among the adult offspring, independently of offspring SES and other potential confounding factors. This suggests SES-related adversity exposures may have a detrimental impact on the size or health of the initial follicle endowment, leading to accelerated follicle loss over time." @default.
• W2799571961 created "2018-05-17" @default.
• W2799571961 creator A5006157581 @default.
• W2799571961 creator A5019369428 @default.
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• W2799571961 creator A5047881704 @default.
• W2799571961 creator A5053830276 @default.
• W2799571961 creator A5063286055 @default.
• W2799571961 creator A5074289517 @default.
• W2799571961 date "2018-03-16" @default.
• W2799571961 modified "2023-10-16" @default.
• W2799571961 title "Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?" @default.
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