FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799572541> ?p ?o ?g. }

• W2799572541 endingPage "93" @default.
• W2799572541 startingPage "82" @default.
• W2799572541 abstract "The gut microbiome influences many, if not all, aspects of human health. Antibiotics, while lifesaving, have the unintended consequence of killing commensal microbiota inhabiting the gastrointestinal (GI) tract, which can lead to overgrowth of opportunistic pathogens such as Clostridium difficile and emergence of antibiotic-resistant organisms. Here, porcine models were developed to evaluate changes to the gut microbiome caused by two distinct types of beta-lactam antibiotics delivered via common administration routes, oral amoxicillin and intravenous ertapenem. Amoxicillin is one of the most often used broad-spectrum antibiotics, frequently prescribed to young children. Ertapenem, a carbapenem considered a last resort antibiotic, is used sparingly in humans and prohibited for use in animals. Cohorts of normal pigs (n = 5) were treated with amoxicillin (20 mg/kg, PO, BID) or ertapenem (30 mg/kg, IV, SID) for seven days. Microbiomes were evaluated using whole genome shotgun metagenomics analyses of fecal DNA collected prior to, during, and after antibiotic treatment. Each antibiotic resulted in significant and distinct changes in the microbiome, causing elimination of key commensal bacterial species and overgrowth of other, potentially pathogenic taxa. In addition, amoxicillin promoted propagation of a broad range of antibiotic resistance genes, many encoding efflux pump components and beta-lactamases, while ertapenem triggered emergence of genes encoding vancomycin resistance, and beta-lactamases, including the carbapenemase, IMP-27. Notably, microbiota alterations and antibiotic resistance gene propagation displayed unique patterns following exposure to amoxicillin or ertapenem. These data underscore the importance of understanding consequences of individual antibiotic use to predict and potentially mitigate adverse outcomes. The porcine models developed here can facilitate evaluation of therapeutic interventions to prevent antibiotic-mediated microbiome disruption." @default.
• W2799572541 created "2018-05-17" @default.
• W2799572541 creator A5013637667 @default.
• W2799572541 creator A5037992484 @default.
• W2799572541 creator A5048270390 @default.
• W2799572541 creator A5073066638 @default.
• W2799572541 creator A5087222147 @default.
• W2799572541 date "2018-10-01" @default.
• W2799572541 modified "2023-10-18" @default.
• W2799572541 title "Distinct consequences of amoxicillin and ertapenem exposure in the porcine gut microbiome" @default.
• W2799572541 cites W123030229 @default.
• W2799572541 cites W1543317050 @default.
• W2799572541 cites W1834855158 @default.
• W2799572541 cites W1965143457 @default.
• W2799572541 cites W1976263734 @default.
• W2799572541 cites W1983871291 @default.
• W2799572541 cites W2004413279 @default.
• W2799572541 cites W2013470122 @default.
• W2799572541 cites W2018445772 @default.
• W2799572541 cites W2025786976 @default.
• W2799572541 cites W2032605132 @default.
• W2799572541 cites W2033617629 @default.
• W2799572541 cites W2034189943 @default.
• W2799572541 cites W2034506148 @default.
• W2799572541 cites W2043442946 @default.
• W2799572541 cites W2057710367 @default.
• W2799572541 cites W2058415702 @default.
• W2799572541 cites W2086018751 @default.
• W2799572541 cites W2086307313 @default.
• W2799572541 cites W2099837668 @default.
• W2799572541 cites W2108124258 @default.
• W2799572541 cites W2108709192 @default.
• W2799572541 cites W2111502970 @default.
• W2799572541 cites W2117727476 @default.
• W2799572541 cites W2122053245 @default.
• W2799572541 cites W2127768597 @default.
• W2799572541 cites W2134712698 @default.
• W2799572541 cites W2134830426 @default.
• W2799572541 cites W2141125135 @default.
• W2799572541 cites W2146624345 @default.
• W2799572541 cites W2149031002 @default.
• W2799572541 cites W2151450070 @default.
• W2799572541 cites W2151496242 @default.
• W2799572541 cites W2179036997 @default.
• W2799572541 cites W2223317528 @default.
• W2799572541 cites W2313028143 @default.
• W2799572541 cites W2342170534 @default.
• W2799572541 cites W2342540743 @default.
• W2799572541 cites W2343175653 @default.
• W2799572541 cites W2344149427 @default.
• W2799572541 cites W2521321100 @default.
• W2799572541 cites W2550479615 @default.
• W2799572541 cites W2552936918 @default.
• W2799572541 cites W2560577918 @default.
• W2799572541 cites W2560608220 @default.
• W2799572541 cites W2567760185 @default.
• W2799572541 cites W2593063328 @default.
• W2799572541 cites W2769199871 @default.
• W2799572541 cites W2770059665 @default.
• W2799572541 cites W2792021903 @default.
• W2799572541 cites W282661992 @default.
• W2799572541 cites W2949237878 @default.
• W2799572541 cites W2952564192 @default.
• W2799572541 doi "https://doi.org/10.1016/j.anaerobe.2018.04.012" @default.
• W2799572541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29689301" @default.
• W2799572541 hasPublicationYear "2018" @default.
• W2799572541 type Work @default.
• W2799572541 sameAs 2799572541 @default.
• W2799572541 citedByCount "30" @default.
• W2799572541 countsByYear W27995725412019 @default.
• W2799572541 countsByYear W27995725412020 @default.
• W2799572541 countsByYear W27995725412021 @default.
• W2799572541 countsByYear W27995725412022 @default.
• W2799572541 countsByYear W27995725412023 @default.
• W2799572541 crossrefType "journal-article" @default.
• W2799572541 hasAuthorship W2799572541A5013637667 @default.
• W2799572541 hasAuthorship W2799572541A5037992484 @default.
• W2799572541 hasAuthorship W2799572541A5048270390 @default.
• W2799572541 hasAuthorship W2799572541A5073066638 @default.
• W2799572541 hasAuthorship W2799572541A5087222147 @default.
• W2799572541 hasConcept C104317684 @default.
• W2799572541 hasConcept C143121216 @default.
• W2799572541 hasConcept C15151743 @default.
• W2799572541 hasConcept C2778368673 @default.
• W2799572541 hasConcept C2779375183 @default.
• W2799572541 hasConcept C2779708577 @default.
• W2799572541 hasConcept C2994496256 @default.
• W2799572541 hasConcept C501593827 @default.
• W2799572541 hasConcept C54355233 @default.
• W2799572541 hasConcept C86803240 @default.
• W2799572541 hasConcept C89423630 @default.
• W2799572541 hasConcept C91478284 @default.
• W2799572541 hasConcept C94665300 @default.
• W2799572541 hasConceptScore W2799572541C104317684 @default.
• W2799572541 hasConceptScore W2799572541C143121216 @default.
• W2799572541 hasConceptScore W2799572541C15151743 @default.
• W2799572541 hasConceptScore W2799572541C2778368673 @default.
• W2799572541 hasConceptScore W2799572541C2779375183 @default.

• next