FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799589053> ?p ?o ?g. }

• W2799589053 abstract "Significance In translation initiation, a preinitiation complex (PIC) of the 40S ribosomal subunit, eukaryotic initiation factors (eIFs), and initiator transfer RNA (tRNA i ) scans the mRNA for an AUG codon in favorable context. AUG recognition evokes a closed PIC conformation and triggers dissociation of eIF1. Structural data predict that a clash between eIF1 β-hairpin Loop 2 and tRNA i impedes selection of non-AUG start codons in the open, scanning conformation of the PIC. Supporting this model, we show that alanine substitutions of Loop 2 residues increase initiation at suboptimal start codons (UUGs and AUGs in poor context) in vivo and destabilize tRNA i binding at UUG codons in reconstituted PICs in vitro. These results establish Loop 2–RNA i interaction as a key determinant of initiation accuracy." @default.
• W2799589053 created "2018-05-17" @default.
• W2799589053 creator A5047015000 @default.
• W2799589053 creator A5091088864 @default.
• W2799589053 date "2018-04-16" @default.
• W2799589053 modified "2023-10-02" @default.
• W2799589053 title "eIF1 Loop 2 interactions with Met-tRNA _i control the accuracy of start codon selection by the scanning preinitiation complex" @default.
• W2799589053 cites W1493552793 @default.
• W2799589053 cites W1577047807 @default.
• W2799589053 cites W1755978981 @default.
• W2799589053 cites W1974640862 @default.
• W2799589053 cites W1990047225 @default.
• W2799589053 cites W2024366860 @default.
• W2799589053 cites W2052543720 @default.
• W2799589053 cites W2054884192 @default.
• W2799589053 cites W2061136057 @default.
• W2799589053 cites W2081400315 @default.
• W2799589053 cites W2083211507 @default.
• W2799589053 cites W2091668708 @default.
• W2799589053 cites W2103059305 @default.
• W2799589053 cites W2106459512 @default.
• W2799589053 cites W2109535551 @default.
• W2799589053 cites W2113981881 @default.
• W2799589053 cites W2114250673 @default.
• W2799589053 cites W2119374287 @default.
• W2799589053 cites W2121305410 @default.
• W2799589053 cites W2137649514 @default.
• W2799589053 cites W2145502099 @default.
• W2799589053 cites W2146339805 @default.
• W2799589053 cites W2147401901 @default.
• W2799589053 cites W2155102851 @default.
• W2799589053 cites W2155441706 @default.
• W2799589053 cites W2155552623 @default.
• W2799589053 cites W2170625826 @default.
• W2799589053 cites W2171819173 @default.
• W2799589053 cites W2607484679 @default.
• W2799589053 cites W2738618519 @default.
• W2799589053 cites W2739048070 @default.
• W2799589053 cites W2916336743 @default.
• W2799589053 cites W4243618453 @default.
• W2799589053 cites W4248187430 @default.
• W2799589053 cites W4254469624 @default.
• W2799589053 doi "https://doi.org/10.1073/pnas.1800938115" @default.
• W2799589053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5939108" @default.
• W2799589053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29666249" @default.
• W2799589053 hasPublicationYear "2018" @default.
• W2799589053 type Work @default.
• W2799589053 sameAs 2799589053 @default.
• W2799589053 citedByCount "26" @default.
• W2799589053 countsByYear W27995890532018 @default.
• W2799589053 countsByYear W27995890532019 @default.
• W2799589053 countsByYear W27995890532020 @default.
• W2799589053 countsByYear W27995890532021 @default.
• W2799589053 countsByYear W27995890532022 @default.
• W2799589053 countsByYear W27995890532023 @default.
• W2799589053 crossrefType "journal-article" @default.
• W2799589053 hasAuthorship W2799589053A5047015000 @default.
• W2799589053 hasAuthorship W2799589053A5091088864 @default.
• W2799589053 hasBestOaLocation W27995890531 @default.
• W2799589053 hasConcept C101762097 @default.
• W2799589053 hasConcept C104317684 @default.
• W2799589053 hasConcept C105580179 @default.
• W2799589053 hasConcept C106774688 @default.
• W2799589053 hasConcept C149364088 @default.
• W2799589053 hasConcept C150194340 @default.
• W2799589053 hasConcept C153957851 @default.
• W2799589053 hasConcept C176990463 @default.
• W2799589053 hasConcept C188740287 @default.
• W2799589053 hasConcept C4718897 @default.
• W2799589053 hasConcept C54355233 @default.
• W2799589053 hasConcept C67705224 @default.
• W2799589053 hasConcept C70721500 @default.
• W2799589053 hasConcept C86803240 @default.
• W2799589053 hasConcept C88478588 @default.
• W2799589053 hasConcept C95444343 @default.
• W2799589053 hasConceptScore W2799589053C101762097 @default.
• W2799589053 hasConceptScore W2799589053C104317684 @default.
• W2799589053 hasConceptScore W2799589053C105580179 @default.
• W2799589053 hasConceptScore W2799589053C106774688 @default.
• W2799589053 hasConceptScore W2799589053C149364088 @default.
• W2799589053 hasConceptScore W2799589053C150194340 @default.
• W2799589053 hasConceptScore W2799589053C153957851 @default.
• W2799589053 hasConceptScore W2799589053C176990463 @default.
• W2799589053 hasConceptScore W2799589053C188740287 @default.
• W2799589053 hasConceptScore W2799589053C4718897 @default.
• W2799589053 hasConceptScore W2799589053C54355233 @default.
• W2799589053 hasConceptScore W2799589053C67705224 @default.
• W2799589053 hasConceptScore W2799589053C70721500 @default.
• W2799589053 hasConceptScore W2799589053C86803240 @default.
• W2799589053 hasConceptScore W2799589053C88478588 @default.
• W2799589053 hasConceptScore W2799589053C95444343 @default.
• W2799589053 hasIssue "18" @default.
• W2799589053 hasLocation W27995890531 @default.
• W2799589053 hasLocation W27995890532 @default.
• W2799589053 hasLocation W27995890533 @default.
• W2799589053 hasLocation W27995890534 @default.
• W2799589053 hasOpenAccess W2799589053 @default.
• W2799589053 hasPrimaryLocation W27995890531 @default.
• W2799589053 hasRelatedWork W2006406846 @default.
• W2799589053 hasRelatedWork W2026184960 @default.

• next